<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32385

Description ATP-dependent DNA helicase Q-like 4A
SequenceMINSNQMSRSHLPEVQKPRGPQTNWSEHAKALESSSSVTKFLSSNVLYALESQKPRDMAARSIAFPSVNVHTLAHPQISKAWRALSSLSVNNTYLRPGVTPPIDVGTNDSYSARERSTAKVISSTGGSVYSSTRPNLSAMNVSGTGRSFHSFPSSVPGDDKIVAEKFPRGNNEIRESEPSCTHLNGVEKSFGNSAFPAEQFESRKACLDDMDDDDILENIDVDQIVMEHYHSTSTPQPSVSNFSLRTPPVDRSASRLEEECNLPPELCSNCSHGIKLGLCPEASTHVEQMKDVLLAISNELLDDATDLSPDRVGQLRQERLRLKKQIQQLENHIRDKESQKSQFLSSTATRIFQYETPKSTNYKMDQPQTDFRAHVSDQGRYACDSWNTPRDSSFSVDRYGLSSAPVEREQYVPKIIDVTYTEGSNDKKWSSREFPWTRKLEVNNKKVFGNHSFRPNQREIINATMSGSDVFVLMPTGGGKSLTYQLPALICGGITLVISPLVSLIQDQIMNLLQANIPAASLSAGMEWAEQLKIFQELNSEHSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAHCVSQWGHDFRPDYQSLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKKCLEDIDKFIKENHFDECGIIYCLSRMDCEKVSERLQEFGHKAAFYHGSMEPEQRAFIQTQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYGYGDYIRVKHMISQGGVDQSPMATGYNRVASSGRLLETNTENLLRMVRYCENEVECRRFLQLVHLGEKFDSTNCKKTCDNCCSSQSLIDKDVTLITRQLVELVKQTGERFSSAHILEVYRGSLNQMVKKHRHETLQFHGAGKHLSKIEVSRILHYLVTEDILVEDVRKSDMYGSVSSLLQVNNAKATILFSGSQTIVMKFPSSVKVLKPSKQGATAAKGPLTSEKQSTLPLTTEDAPPKDVNLSANMYTALRKLRTALVKEAPDGVMAYHIFINSTLQQISRRIPRTKEELLEINGLGKAKVSKYGDQLLETIETTVNEYYGTNKKDSIISNDSPDSGKRRRDENISPNVAEDDDFEVSPSQSCKKTVRNKSNEVLHGECIDGDRRGMELDFDFKDEDGSEIRPEGRVLPW
Length1188
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.07
Grand average of hydropathy-0.526
Instability index50.87
Isoelectric point6.82
Molecular weight133310.97
Publications
PubMed=11058127
PubMed=11130712
PubMed=27862469
PubMed=14593172
PubMed=12856935
PubMed=16146519
PubMed=16371241
PubMed=18000056
PubMed=19096507
PubMed=21265901
PubMed=24265739

Function

Annotated function 3'-5' DNA helicase involved in DNA repair (PubMed:16146519, PubMed:18000056, PubMed:19096507). Required for the maintenance of genome stability by modulation of the DNA damage response and repression of crossovers. Confers resistance to genotoxic stress (PubMed:16146519, PubMed:18000056). Suppresses spontaneous homologous recombination (HR) events in somatic cells together with its partners RMI1 and TOP3A (PubMed:19096507). Contributes to the maintenance of chromosome integrity during meiosis. Involved in the removal of telomeric bridges that appear to arise during meiotic recombination. Required to resolve or dissolve MSH4-dependent telomeric associations. Does not seem required for chiasma formation (PubMed:21265901). 
ECO:0000269	PubMed:16146519
ECO:0000269	PubMed:18000056
ECO:0000269	PubMed:19096507
ECO:0000269	PubMed:21265901
GO - Cellular Component
chromosome	GO:0005694	IBA:GO_Central
cytoplasm	GO:0005737	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central
plasmodesma	GO:0009506	IDA:TAIR
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IDA:UniProtKB
ATP binding	GO:0005524	IEA:UniProtKB-KW
four-way junction helicase activity	GO:0009378	IBA:GO_Central
metal ion binding	GO:0046872	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro
GO - Biological Process
cellular response to abscisic acid stimulus	GO:0071215	IEUniProtKB
cellular response to cold	GO:0070417	IEUniProtKB
cellular response to DNA damage stimulus	GO:0006974	IMTAIR
chromosome organization	GO:0051276	IMTAIR
DNA duplex unwinding	GO:0032508	IBA:GO_Central
DNA recombination	GO:0006310	IMUniProtKB
DNA repair	GO:0006281	IMUniProtKB
DNA unwinding involved in DNA replication	GO:0006268	IBA:GO_Central
double-strand break repair via homologous recombination	GO:0000724	IMTAIR

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32385
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.77|      28|      79|     801|     830|       2
---------------------------------------------------------------------------
  801-  830 (40.59/41.77)	TGyNRVaSSGRLLETNTENLLRMVRYCENE
  883-  910 (50.17/38.66)	TG.ERF.SSAHILEVYRGSLNQMVKKHRHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     253.07|      81|     156|     172|     252|       4
---------------------------------------------------------------------------
  172-  212 (51.00/26.01)	........................................................................................................................NEIRESE...PSCTHLN.GVEKSFGNSAFPAEQFESRKACLDDMD
  213-  252 (48.94/24.65)	DDDILENI.DVDQIVMEHYHSTSTPQPSVSNFSLRTPPVDR............................................................................................................................
  332-  366 (35.83/15.97)	.........................................sasrleeecnlppelcsncshgiklglcpeasthveqmkdvllaisnellddatdlspdrvgqlrqerlrlkkqiqqleNHIRDKE...SQKSQF.......LSSTATRIFQYETPKSTNYKMD
  369-  470 (117.29/69.86)	QTDFRAHVsDQGRYACDSWNTPRDSSFSVDRYGLSSAPVER...............................................................eqyvpkiidvtytegsNDKKWSSrefPWTRKLEvNNKKVFGNHSFRPNQREIINATMSGSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.63|      38|     509|      24|      61|       5
---------------------------------------------------------------------------
   24-   61 (65.44/37.82)	NWSEHAK...ALESSSSVTKFL.........SSNVLYALESQKPRDMAAR
  528-  577 (52.20/28.81)	EWAEQLKifqELNSEHSKYKLLyvtpekvakSDSLLRHLENLNSRGLLAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.29|      27|     509|     131|     167|       6
---------------------------------------------------------------------------
   96-  123 (41.82/23.22)	RPGVTpPIDV.GTNDSYSARERSTA...KVIS
  134-  164 (38.47/35.91)	RPNLS.AMNVsGTGRSFHSFPSSVPgddKIVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.10|      23|      73|     933|     955|       7
---------------------------------------------------------------------------
  933-  955 (38.82/22.33)	LVTEDILVEDVRKS.DMYGSVSSL
 1008- 1031 (36.28/20.45)	LTTEDAPPKDVNLSaNMYTALRKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32385 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MINSNQMSRSHLPEVQKPRGPQTNWSEHAK
2) NKKDSIISNDSPDSGKRRRDENISPNVAEDDDFEVSPSQSCKKTVRN
1
1101
30
1147










Molecular Recognition Features






MoRF SequenceStartStop




1) MELDFDFKDEDGSEIRPEGRVLPW
1165
1188