<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32382

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSASDAHQLIHKLLLQALARRLPQSKWLSLLHQLIRRTSTAQNDSDQHDPASIPAGSHAAECLVKHMLSQPFVDPLLVEYLQALIYGSANRSGVSPDQGPLTDVMTVALHLLANVQATPNNVSAIETISSVVGQGLLMTFQAPAPFGVSSPTFLALLQHLFVDSAEDKVDPSSSPKQHNQDGVRDGKTTIASLAFVVANLRLLGLAADPSIASPQNLLAPRVAITVLVNVAQALLANVTQALSEAQTSKDHRSKPDDVLLQRMRSTGKSSVAEIEVVLQSMDPAWKDEIALLRSLTSQIGVINQISESFSEATTSKVPLHPAKRKVETLQDAQQRATWDHFLDTTTLASSQKPAVEPEVAFLMHLLVDRHASWDAKLNAVKKLFLARRNAAPPSSTLEKSLTAFYFELLIAGIDACATVVETPPAFKGAEVYAAIWRNALCGMIPELVLQLEQWLDGDQNLPLRGQRLEAPHVRLEAALRAALLVMANRLNTCESATGQAHAHASAALASGGDAPGVDANAMTDVLGLDTPPSQPIKAWLLRACIEHSLARPEAIADEFPDGHKLASEVQSLTQSLRMDAQLEGLALDTLFETRVSTDDPVELLQRVASDPGTQFIFARQLVLQMQDWLEQHDLESIARWSKALTEEACQGGAMLDTVMIYIEPVQLLDPLASILDHQDLGQTSDEPSTLSNILLFVQLLCYRYTIAPSDISRYTSPNSDMNMDDTYAPSDKSGSPFLATHLATSSVSYPLTALSEEDRGLVSRWVHALFGNEGISDDLISASPPTTLLRLSPLLFSQSISACQHGIIDLETLRGGLSYFLQDLLSFALPGALIWLLSEITRTPLQPILDFLSDSGLQSSVADVPSSDGTLANGLPRNATSRTVCLEVLALLVDTDACPASVRELIAKAFDGFVTAIGADATAAATLAAGCETFNLANLKARMEGAGITAELLSKSEGSWLKSLVGQQDSKLVSMVARCSSNRLDRIVGALSRGEIGQRGRDQKALAAWLCLVSPATDLIAPLRFVQKLDLREVEEGAIKNVVRSIGLMLGLIGASEAPRGAGDDTLAKRILSLAKTDAPNGMASKAPAASTSHAGEADLFDDEPSTPPLPTPRATEASADAGSDAALVASIVTSTSLLASRRMNVTSRQILDMLALKLIRFRSALLTRKGTTAGAGKWDLWLDAIADHLEDGLTGSVNIREGAEGDAGEANASVDGLKALLSAMQ
Length1226
PositionTail
OrganismPseudozyma hubeiensis (strain SY62) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Pseudozyma.
Aromaticity0.05
Grand average of hydropathy0.028
Instability index46.05
Isoelectric point5.06
Molecular weight131041.65
Publications
PubMed=23814110

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32382
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.05|      11|      22|     705|     717|       1
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  705-  717 (17.07/17.59)	TIAPSDISryTSP
  726-  736 (22.98/14.33)	TYAPSDKS..GSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.31|      17|      21|    1088|    1106|       3
---------------------------------------------------------------------------
 1088- 1106 (26.03/21.62)	PAASTSHAGEADlfDDEPS
 1108- 1124 (31.28/18.66)	PPLPTPRATEAS..ADAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.30|      16|      21|     257|     272|       4
---------------------------------------------------------------------------
  257-  272 (26.47/15.64)	DVLLQRMRSTGKSSVA
  275-  290 (28.82/17.68)	EVVLQSMDPAWKDEIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     366.27|     122|     171|     353|     486|       5
---------------------------------------------------------------------------
  353-  484 (172.37/126.78)	PAVEPEVAFLMHLLVDrHASwdAKLNAVKKLFLARRNAAPPSSTLEKSLtafYFELLIAGIdACATVVETPPAFKG.AEVYAAIWRNALCGMI..PELVLQLEQWLDgDQNLPLRGQRLEAphVRLEAALRAALL
  531-  655 (193.91/101.10)	PPSQPIKAWLLRACIE.HSL..ARPEAIADEFPDGHKLASEVQSLTQSL...RMDAQLEGL.ALDTLFETRVSTDDpVELLQRVASDPGTQFIfaRQLVLQMQDWLE.QHDLESIARWSKA..LTEEACQGGAML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      15|      15|     815|     829|       7
---------------------------------------------------------------------------
  815-  829 (25.71/11.70)	GGLSYFL........QDLLSFAL
  831-  853 (17.75/ 6.02)	GALIWLLseitrtplQPILDFLS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32382 with Med5 domain of Kingdom Fungi
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