<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32379

Description RNA polymerase II mediator
SequenceMASLQSSMLRGGAGGSGAAGRGLPSSTSKRSKQDEARLPEAYQQEKPPWRPPLHPASSDRGVPDLFPTKPGQPEDDMSQISVRKGFAPRSHVQNESFSAHDAIYARLAAPDAIRTLSSWMDEVVQRRRQLDRASVAPSQYKPPSRVTLNDTKLANYVKDLADPSVPLTRLSRSVPHGFRGEKLFEMLWAGGALPSSGAAAAAAAATSNYFHSRTPAASSASTPSANASVAATPAPRKSVDISRAVWFIRALGAAELSSLRNKSAATIIPEITSNLCTWMAKQIAELNLVQTAESSSTAAPSPAPTSPSTHLPRTPGAAPMPLSRSVAAAHLARTPSNLHLASSPSSAPAKEVCAVLQNEVDEERWVAKWSYSLSLARHLHAQSLLDRSTLVRWIVDAFAASNLVQLPFLLELVQEVLVLILRRRCFAKPFLTALLVQISNVDARLNLVAGGGLRTKLVLLFRIVCENSPDSLISARLWSEHAITLTQLLNETNSDAQVPAPPHHVLEFVEQAVRPRVDRLLLRSQTSGPENLLSLPLQQHVDVQALDSFDIRTIDRVFLLNVSGSHRHARHDRDDAVWVPRIETILTWACTDRRSGVVRQYLAATLIEKIRFGVSWEESSEESDQVSLPAFDLDDHSKKTRKINVEPMLIKWLGDVETSLNQKAGEASDPARSTLLATVDVSAIVVLVGELARRGVFSYTKYLQRLIARGMTTAPSSGSTEHAISTGDGAPAPAATSRDSLHLRLLRSLPLYDQPASVYQQRKQAIYGDRTKETYEDAAQRRALRQLQSFLPFAFAQDADAVEGSHIVAPPPEASPSDLEKDLSRLWSASRFVRCRLLRNELLPAVTARVESLNGEQLSQVSAVLVAADDFEGLAQLLASLLLRPLSDSIARAAFNMVIEHSLVWRSMDILGTLKQLVRQQLNHSSSVRNDRQAVMASTTLLRLRTLIERLPPRVSAPALETNPEHDAMQQHVQALRPNVDALLDRFAKLTRSSSESSGNSASASSPVDGSDMLTPFRSLFVQADATCDEMIERAIVESVLACGDVSIVPAAVRLIDQLYLEASLEIDERHARWLSHLVVSIEQGTHSDACIRALLHLLTRLIAHGTLNLQLAMDAFLLPYTTYAVRRLTDPATRGADATLHLGAAVSSLGDMFASLLGEMAHATSYEDSRAFGAQTTLLFARDNLPSLLRLATCLICASDEPSALASADKTQIESFWRALLRSEPMHIAFRQDPRLCLLTVKDTCKSMWGCNPSRVIDLAIACLDPTSLLLRDVATIDAASVKSRLDAWYTAVVANELVEIFERLQLVESSFQSRADSKTKALASGIFDDLFVRLPDIGAQLVRDCHSSGLVSRFTDIGIKLLSDRVKAAGASETKPQQQLDSALDGDAPASVDDGVEASSADEREVESTLRSVLRMCEQQDGFVFNATDADSCGQLLLHVIASLEAALGQIATRPDDDAPRLSALLQDGMSFPLLHLVLRFGCLWSGAMRTVALRLVKVLFELLRRAGEKAQCGGTFALLLDSLNFVLDELPPQLLGACLPELEMQLQTTELATHERTEKLRQLSCRLDDASTAGGWFVAPSAGAAVKKGWFTPGGLNPWECAEYLDAPPAAAASGGAAGNAVRTGPIQSRGAAAAQSPAAADGDTSTTLPGARTGWISKLSLNTAIPSYMLGLRVTRDLVPHYASPASPGAASIGSNDASSSQPSSTSTTAAASTGNAAAAVSSSTATTAASAAVMDGEDALATLPIFVESERTYGERTAGEPVFSRDLRRGLLVRARLPRIVANEREQVEAAPATEESEAIQVIDLTWDDDEMPLHEPQSQNGGSGMSRKRRLSKRDA
Length1842
PositionKinase
OrganismPseudozyma hubeiensis (strain SY62) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Pseudozyma.
Aromaticity0.05
Grand average of hydropathy-0.121
Instability index54.19
Isoelectric point6.06
Molecular weight198955.22
Publications
PubMed=23814110

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32379
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     166.93|      27|      31|     230|     256|       1
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  230-  256 (42.81/21.02)	AATPA...................PRKSVDISRAV.WFIRALGAAEL
  264-  286 (32.43/14.10)	AATII...................PEITSNL..CT.WMAKQI..AEL
  307-  331 (35.17/15.93)	PSTHL...................PRTPG..AAPM.PLSRSVAAAHL
  332-  373 (24.23/ 8.65)	ARTPSnlhlasspssapakevcavLQNEVDEER...WV..AKWSYSL
  376-  403 (32.29/14.01)	ARHLH...................AQSLLDRSTLVrWIVDAFAASNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.68|      49|      71|    1192|    1262|       2
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 1192- 1248 (65.38/77.59)	LATCLIcaSDEPSALASADKTQIESFWRALLRSEPMHIaFRqdpRLCLltVKDTCKS
 1267- 1315 (78.30/37.48)	PTSLLL..RDVATIDAASVKSRLDAWYTAVVANELVEI.FE...RLQL..VESSFQS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.86|      44|      77|    1610|    1655|       3
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  191-  217 (32.38/ 9.94)	..................GALPSSGAAAAAAAATSNYFHSRT.PAA
  713-  735 (29.01/ 8.10)	.................TAPSSGSTEHAISTGDGAP......APAA
 1610- 1655 (69.15/35.10)	APPAAAASGgaAGNAVRTGPIQSRGAAAAQSPAAADGDTSTTLPGA
 1690- 1733 (69.32/30.54)	ASPGAASIG..SNDASSSQPSSTSTTAAASTGNAAAAVSSSTATTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.63|      28|      77|    1412|    1450|       4
---------------------------------------------------------------------------
  781-  809 (43.91/15.66)	RRALRQLQSFLPFAF.AQDADAVeGS...HIVA
 1413- 1444 (42.72/40.95)	RSVLRMCEQQDGFVFnATDADSC.GQlllHVIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.71|      22|      25|     581|     604|       5
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  581-  604 (32.45/35.01)	RIETILTWACTDRRSGVVRqyLAA
  609-  630 (37.27/30.27)	KIRFGVSWEESSEESDQVS..LPA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     315.88|      86|     344|     466|     551|       6
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  466-  551 (149.03/86.31)	ENSPDSLIS..ARLWSEHAI..TLTQLL.NETNSDAQV.................................PAPPHHVLEFVEQAVRPRVDRLLLR........SQT.SGPENLL.SLPLQQHVDVQALDSFDI
  813-  897 (104.50/58.09)	EASPSDLEKdlSRLWSASRF..VRCRLLrNEL.....L.................................PAVTARV.ESLNGEQLSQVSAVLVA........ADDfEGLAQLLaSLLLRPLSDSIARAAFNM
  900- 1007 (62.35/31.39)	EH...SLV......WRSMDIlgTLKQLVrQQLNHSSSVrndrqavmasttllrlrtlierlpprvsapaleTNPEHDAMQQHVQALRPNVDALLDRfakltrssSES.SGNSASA.SSP...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.26|      15|      20|    1332|    1346|       8
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 1332- 1346 (26.68/15.87)	LFVRLPDIGAQLVRD
 1352- 1366 (25.58/14.91)	LVSRFTDIGIKLLSD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.83|      18|      18|    1463|    1480|      10
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 1463- 1480 (30.80/18.01)	RLSALLQDGMSFPLLHLV
 1482- 1499 (33.03/19.88)	RFGCLWSGAMRTVALRLV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.91|      43|      92|      41|      86|      15
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   41-   86 (74.87/48.54)	AYQQEKPPWRPPLHPASSDRGVPDLfpTKPGQPEDDMSQiSVRKGF
  136-  178 (78.04/40.76)	APSQYKPPSRVTLNDTKLANYVKDL..ADPSVPLTRLSR.SVPHGF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32379 with Med12 domain of Kingdom Fungi
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