<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32377

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPLSPYGANTSTPHQHVKQIGRSSPASSRPPSLAHTQPIMASNGSVHYHAASPSAAVDRNKQMASSPHKLMIGVPPAATPNLSSVSNGVHDTRQSNGIASSTTTTAAAADVKGKQKEVDPIEAIPLAQLEQELPLEEADLVSLAALVERLANFGYESLQNLAETLPSLPSSSKRAKIFNTALDVRKQFIKLLVLARWSKDVADLNKSRNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLQTGSYRRLPASIKDMAVAPKPFTDQQALAIVTRLEDALRTRMACRELVPAPLSNYSIHDGKVHFHVPDFFDAQLAASGAGQDETVNHRSDEPTPPSSDDRWWLLDLSFDFTPTGSCAESSRKSFPRKPKRAFRERLRVWGDRELAPRAQSESNDESKSVPLETGATEIEVGADAQDAVEKTTALIEGKDSDIPKDIDKDDLATVKHTVERDAPLARLFAFLQERSLHYQMDVLQHQAFELCRLNWGTNLRIETGERPRRLTVYYWTQAQGAAGAKGRAEGPAAGGSVQITIVDLPDQPGAKKALAAMFDEGDEESSKANETASLITVKRRGLQVTWNAEKSILADSETHDLAVSSSSLDIESLLSLVIKRHTLALLRNLHRRILVSEHPVSRLLRPEDCTLSEEHSQRQGDEFSTATEMTSFSFLQIALQGSHHQRGAKLKQRSTSSVPALRLSVDPVTGRLLLHSETTRSTTDQDTQMLSRQAAGFTASILTTRATYSRLTEASDRINESIEAVFDVLYKLEVFARVEEWERMSSHLGLRAVRKLALRPQDLAKFGPSVSTSPEAVPRLFVPLRNSFPGYFLALQPSELAGVGIALVYIAQTLDATGVPSLALQSIEWLDRSKIAAAASEAGRDNDIDAGTMNREDGRKRKGAPSISARQSDPDLVQKNLTTEELADVHSYCIALVSYFRVEQQLRLRGIPYLHVGSNTLRSSPPAKLQKRRRSADRAVQAAEARDDGLFDDDGNFDAAAALHAMADVTPAHSDDEATQGGERNGVAALVPSLCLRAADLLGPAKAHLAKPNVSLRVRNWDDSDRSCVQMRIKLRMKSRRFRSLHEVVSLAPTADQHSSSALTWIDFDSETSLLTLSTRDLDNCILTLYTQWERAMRMVLITREVLNASRAWQQRALRSRVSCKKPAERVELRCFDFDKVIFSYGNTVVNGSECKLLVRVRWQDAKMEIQPFTNLTTTQMGGYILEFGSIPTAGLDVFDRDAAQRVKDSPNWFDDAHASANPHNAMAFELRRTVNVAARSAAIHSVVQPQSERMVWKGFFQLLQDTLPLAREMAPLVERCLTDADVPEVEIKGATWFRLRFKDRFAVDLRMATRSRLIVSDASRPLFRSEIQKQDGDAVSPDAGANAETGLFAGSELLNGLLAGKAVANTAEGEDSKASQKPRISAAMSNEATLTGRQFQPIPNIEQVLRKVQAGIQTASSARGAAAVWDLRRALLISLAPFTSPNLAGQPSSAKGGNGVLGNLISSLVECVSAEIGSGSSGGDQS
Length1529
PositionTail
OrganismPseudozyma hubeiensis (strain SY62) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Pseudozyma.
Aromaticity0.06
Grand average of hydropathy-0.353
Instability index52.29
Isoelectric point6.85
Molecular weight167544.13
Publications
PubMed=23814110

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32377
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.23|      56|     100|     878|     936|       1
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  878-  936 (84.87/69.27)	AAAASEAgRDNDI..DAGtmNREDGRKRKGAPSISARQSDPDLVQKNLTTEELADVHSYCI
  981- 1038 (89.36/60.79)	AVQAAEA.RDDGLfdDDG..NFDAAAALHAMADVTPAHSDDEATQGGERNGVAALVPSLCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.76|      45|     195|    1059|    1110|       6
---------------------------------------------------------------------------
 1059- 1110 (77.72/69.44)	RVR...NW.DDSDRSC...VQMRIKLRMK...SRRFRSLHEVVslaptadQHSSSALTWIDF
 1248- 1302 (62.04/40.78)	RVKdspNWfDDAHASAnphNAMAFELRRTvnvAARSAAIHSVV.......QPQSERMVWKGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.74|      84|     195|     296|     414|       7
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  323-  414 (126.05/116.30)	DAQLAASGAGQDE......TVNHR.SDEPTPPSSDDrwwLLDLSFDftpTGScAESSRKSFPRKPKRAFRERLRV.WgDRELAPRAQSESND...ESKSVPLE
  519-  613 (118.69/51.22)	QAQGAAGAKGRAEgpaaggSVQITiVDLPDQPGAKK...ALAAMFD...EGD.EESSKANETASLITVKRRGLQVtW.NAEKSILADSETHDlavSSSSLDIE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.57|      25|     196|    1159|    1183|       8
---------------------------------------------------------------------------
 1159- 1183 (46.02/31.58)	ALRSR..VS.CKKPAERVELRCFDFDKV
 1355- 1382 (34.55/21.62)	ATRSRliVSdASRPLFRSEIQKQDGDAV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32377 with Med14 domain of Kingdom Fungi
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