<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32375

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIDKLGIFAELDSNTTAELHSSQTARHLTCHVFLGYHIDRRRVLQAEFERRNGQNSRKEHRNSKSTSVRCLNEVEERTVDGLQSQKTPSMAEQLRLVVSVNRFRLQVPSVFRSGPLHKLGSHRLDSAWPRFNDTVLDSTISTACSLAISTQLCTPPAKEATGEHAPALESSHIFEQCKPTLEALMSYNFTPMWNQGSASAAAGGGGSVGASGSIHNSAGPHTTGSFASHTRSNSMTHNTAAHRRVAGINQQQHASSPSGPSSYPRPFANVAFPGTVSAPRSAAAPNTPSAPPKSLQRLPILTTHTPTSIAKLAFPPHTTIFWHRLRPVISDPLTHQSLDQRRADGSASTMPTSSTSHLDARKAWNAAVLQVITAARQSTLQPNATDASLSGSQEPLQPLLQAPLIHANSRPSSSRSDAHPASLGPTSDLWVFVGVTDQSELRSSDAPNNVAIAASAANVVTSDSTTSDDTSKAFNSSMLVHPALARRVSPELLKSLASLSPSAHATSGSYLLAAASIDATDDKGKLSSLSSDQRQAHKRFMSSLRLRLTDSLASAPTTSAQQLKTTKSASRTRLRLGDSIVFLPQTPSRSLKKAISDAAWFAAPGQQKALRDGDDEPASLLVRATLSLTPSSLFVRASYCRLTAIPLLETRHSNFSSSLPSSLPHPTVLIAPLDRRVHLIGMVPSSSFAEEHLAELAHRFASLNIASHYQEEDTQSVLASGLAICAPPHSGSQPNDQVSHEQDLQRLQDVSSVTAVRSETIDESMPFAFTAETHKHAHSDSSHLVPGPNRFLWPAAWCLVLPDLRILATRGLRTDDLHNAQSQPMTPLKELVAFTLKVLNDANESSHAQSSSAYTPNDPDDASVSLHRADRMPSTRPEITPASITFADFDFAMPTVASATSSHTLPAAGQSVTGSSPLKRDYMPSEPVLAASNTEAFGQDLSWTQFLPHQSSSAITSASASTSAVPANPLTTLGAATAQNSALDGAQPSQLDHRDAGWLLSAGSASSRDAQAQEQPRALVNPQSLLPPHTDLQSESSTTMQNPQGAHLAPTQSTSTKRKAGEGDIFDNLDLLTEDDFSFFDESAFDLHPGEALSQQIDQPALPSHAIPTQELMIAGNASSAPASSLVAGSQPVAAPAAAILGDVAMDDVGQSSLDALFSAIPGLQHAMVSTEMSNAQAAVPQPTSSSPTAMQATHIRMAHGGPQDMVAPTTGTAHPLSSTMSSFTPRDPGGATPFGDPASLPGFTPSSLTESSPAFGNPQYKTPRTPYSPVEDYRDGAAIVDLQNSNRFQESVASARDRNAGSATEAHAINKDPLAKREAEDQLRLADASTAAAAAAHAAMEMDPSNRKRLAIVPNAFLPISQPEARKPLQRLAAGARANLGRKYDLLGKFASRPKTATASMTTSHANNVALPERRPSGDASRISDRGDRDSAPESDRPGTQSLTPHPGLSAARPSPSKTPSGRGQALLQLRRDRRSKPSPAFTLTTLRRSSSSRAIDGPATPRSSDDFARPGAVSGSDSDTSSSSDDNSDDAPSDSEATVMTLSPVDQASLKASSLDVITAFLSGGMQSPRSHWLGALYDAPDRSSSARSHSARPSASVPPLQGDARTDLTTGTVAALHKSSVRRWMLSRTAEWLIQNPQFRSMYCASSAARPTWPGIAIGDKIELLQSMASALSIAPDPDASKPPIDQDSATIKAETHFAAVPTLKSLVKLSGAAANAVIADGSGAEVAEVFEPARIAVGCQGSVVEALPSALNLWDKSKLSAVSGQKHVVAKVLLTDASPAWHEEIVAWLDRLRVAFETHGLGTHVGGAHSILAVADGSESLPLSSYLDQLWTDGETWLDTLRSISSRVQLDLLQGKHVVVYTLQPSASATCGSTGFHGLLRLERDLRAMLSEQVGVLAEQLLVRVVSPTMMTESGSLGFGQQTQMVRRLAFSVYDQLARLVRRQPAKVLHGKEPGPISAVVQFPAFSLSTGSETSSAASSTAAKAGRTNFSLSWPQEPAAVTDERVLLHVGYRICRTSSGEDGVGVQMDKTPSRNGSAASIDAAGVFGLDKPMDAEDRAPTKQESVVMVSAIDERGGSSSVDALAANDGDSSIEACVDRVWQFAVGEASRARVQWRLIVSSTGPMSRREKQAWERLIEAYWASTVAGNRVMGSVMLMSARPDESGAILAERGARAKVNQEWSATASTDKSSLMLLDAADFSQAVNFAEPMPMAWTQAVDGSETADEGSEYGEEDKLDEEITAMPIASAILMHHPRPELSNGVGNAGGRSHDGLGKHRLDGSTSTSHVMAVDLLQVWPAPATLQTDAQAQVAEDAAASANNEAMDAILRSLHRLRLISQERHQLPWPYSAQPWPVASVNALAACLEGVVLRD
Length2375
PositionKinase
OrganismPseudozyma hubeiensis (strain SY62) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Pseudozyma.
Aromaticity0.05
Grand average of hydropathy-0.329
Instability index54.90
Isoelectric point6.13
Molecular weight251975.87
Publications
PubMed=23814110

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32375
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     463.63|      94|      94|    1279|    1372|       1
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  342-  423 (64.51/21.21)	...............RAD.GSastmptSSTSHldarkAWNAAVLQVITAARQSTL.QPN..ATDASLSGSQEpLQ.PLLQ.........APLIHAnSRPSSSRsdahP.........ASL
 1284- 1381 (138.56/54.07)	QNSNRFQESVASARDRNA.GS......ATEAH.....AINKDPLAKREAEDQLRL.ADASTAAAAAAHAAME.MD.PSNR..KRLAIVPNAFLPI.SQPEARK....PLQRlaagARANL
 1382- 1471 (119.15/45.46)	GRKYDLLGKFAS.RPKTAtAS......MTTSH.....ANNVALPERRPSGDASRI.SDRGD.RDSAP....E.SDrPGTQ.....SLTPHPGLSA.ARPSPSK...tPSGR..gqALLQL
 1472- 1511 (31.66/ 6.64)	RRDRRSKPSPAFTLTTLR.RS......SS.SR.....AID.GPATPRSSDDFAR..................................................................
 2271- 2355 (109.75/41.29)	GRSHDGLGK.....HRLD.GS......TSTSH.....VMAVDLLQVWPAPATLQTdAQAQVAEDAAASANNEaMD.AILRslHRLRLISQERHQL.PWPYSAQ....P............
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     535.32|      91|      93|    1084|    1174|       2
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  250-  315 (67.79/22.74)	.........QQqhA..SSPSgpssYPR...PF..............ANVAF.......PGTV......................SAPRSA.A............APNTPSAPPKS.LQRLPI.............LTTHTPTSIAKL..AFP...............................
  816-  900 (88.52/32.12)	DLH..NAQSQP..M...TPL..........................KELVAftlkvlnDANE.....................SSHAQSS..............SAYTPNDP.......DDAsvslhradrmpstRPEITPASIT.....FADFDFAMP.TVAS.................AT
  901-  998 (81.99/29.16)	SSHTLPAAGQS..VtgSSP.....LKRDYMPS..............EPVLA.......ASNTeafgqdlswtqflphqsssaiTSASASTSA............VPANPLTTLGAATAQNSA.............LDGAQPSQLD.................HR...............daGW
  999- 1085 (58.51/18.54)	LLSAGSASSRD..A..QAQE....QPRALVNP..............QSLLP.......PHTD.....................LQSESSTTMqnpqgahlaptqSTSTKRKAGEGDIF..............................................dnldllteddfsffdesAF
 1086- 1176 (130.33/51.02)	DLHPGEALSQQ..I..DQPA....LPSHAIPT..............QELMI.......AGNA.....................SSAPASSLV............AGSQPVAAPAAAILGDVA.............MDDVGQSSLDALFSAIPGLQHAMVSTEMS................nA.
 1177- 1269 (108.18/41.01)	..........Q..A..AVPQ.....PTSSSPTamqathirmahggpQDMVA.......PTTG.....................TAHPLSSTM............SSFTPRDPGGATPFGDPA............sLPGFTPSSLTESSPAFGNPQYKTPRTPYS...................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     306.72|      84|      93|    1768|    1860|       3
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 1718- 1766 (58.12/32.65)	..ANAVIADGSGA.................EVAevFEPARIA..VG.CQGSVV............EALP..SALN.LWDKS..............KLSAV...
 1772- 1860 (135.97/109.29)	VVAKVLLTDASPA.....WHEeivawLDRLRVA..FETHGLGTHVG.GAHSIL......AVADGSESLPLSSYLDQLWTDGETWLDTLRSISSRVQLDLLQGK
 1862- 1956 (112.62/70.01)	VVVYTLQPSASATcgstgFHG.....LLRLERD..LRAM.LSEQVGvLAEQLLvrvvspTMMTESGSLGFGQQTQMVRRLAFSVYDQLARLVRRQPAKVLHGK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.26|      16|      95|     220|     243|       4
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  203-  218 (29.37/17.61)	GGGGSVGASGSI.HNSA
  224-  240 (25.88/16.64)	GSFASHTRSNSMtHNTA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.11|      27|      27|     542|     568|       5
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  490-  516 (35.65/19.51)	PELLKSLASLSPSAHATSGSYLLAAAS
  542-  568 (41.92/24.75)	SSLRLRLTDSLASAPTTSAQQLKTTKS
  570-  596 (39.54/22.75)	SRTRLRLGDSIVFLPQTPSRSLKKAIS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.91|      22|      65|    1514|    1539|       7
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 1515- 1536 (37.10/12.70)	VSGSDSDTSS.......SSDDNSDDAPSD
 1564- 1592 (30.81/ 7.59)	LSGGMQSPRShwlgalyDAPDRSSSARSH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.41|      17|      51|     618|     634|       8
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  618-  634 (28.81/14.98)	ASLLVRATL.SLTPSSLF
  671-  688 (27.60/14.01)	APLDRRVHLiGMVPSSSF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.74|      19|      63|    1965|    1987|       9
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 1965- 1987 (27.51/25.89)	VQFPafslSTGSETSSAASSTAA
 2030- 2048 (34.23/20.59)	VQMD....KTPSRNGSAASIDAA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.56|      52|    1529|     128|     184|      13
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  128-  184 (80.00/63.18)	WP..RFNDTV.LDSTISTACSLAISTQLCTPPAKEatgEHAPALESSHiFEQCkPTLEAL
 1656- 1710 (80.56/47.63)	WPgiAIGDKIeLLQSMASALSIAPDPDASKPPIDQ...DSATIKAETH.FAAV.PTLKSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32375 with Med13 domain of Kingdom Fungi
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