<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32375

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIDKLGIFAELDSNTTAELHSSQTARHLTCHVFLGYHIDRRRVLQAEFERRNGQNSRKEHRNSKSTSVRCLNEVEERTVDGLQSQKTPSMAEQLRLVVSVNRFRLQVPSVFRSGPLHKLGSHRLDSAWPRFNDTVLDSTISTACSLAISTQLCTPPAKEATGEHAPALESSHIFEQCKPTLEALMSYNFTPMWNQGSASAAAGGGGSVGASGSIHNSAGPHTTGSFASHTRSNSMTHNTAAHRRVAGINQQQHASSPSGPSSYPRPFANVAFPGTVSAPRSAAAPNTPSAPPKSLQRLPILTTHTPTSIAKLAFPPHTTIFWHRLRPVISDPLTHQSLDQRRADGSASTMPTSSTSHLDARKAWNAAVLQVITAARQSTLQPNATDASLSGSQEPLQPLLQAPLIHANSRPSSSRSDAHPASLGPTSDLWVFVGVTDQSELRSSDAPNNVAIAASAANVVTSDSTTSDDTSKAFNSSMLVHPALARRVSPELLKSLASLSPSAHATSGSYLLAAASIDATDDKGKLSSLSSDQRQAHKRFMSSLRLRLTDSLASAPTTSAQQLKTTKSASRTRLRLGDSIVFLPQTPSRSLKKAISDAAWFAAPGQQKALRDGDDEPASLLVRATLSLTPSSLFVRASYCRLTAIPLLETRHSNFSSSLPSSLPHPTVLIAPLDRRVHLIGMVPSSSFAEEHLAELAHRFASLNIASHYQEEDTQSVLASGLAICAPPHSGSQPNDQVSHEQDLQRLQDVSSVTAVRSETIDESMPFAFTAETHKHAHSDSSHLVPGPNRFLWPAAWCLVLPDLRILATRGLRTDDLHNAQSQPMTPLKELVAFTLKVLNDANESSHAQSSSAYTPNDPDDASVSLHRADRMPSTRPEITPASITFADFDFAMPTVASATSSHTLPAAGQSVTGSSPLKRDYMPSEPVLAASNTEAFGQDLSWTQFLPHQSSSAITSASASTSAVPANPLTTLGAATAQNSALDGAQPSQLDHRDAGWLLSAGSASSRDAQAQEQPRALVNPQSLLPPHTDLQSESSTTMQNPQGAHLAPTQSTSTKRKAGEGDIFDNLDLLTEDDFSFFDESAFDLHPGEALSQQIDQPALPSHAIPTQELMIAGNASSAPASSLVAGSQPVAAPAAAILGDVAMDDVGQSSLDALFSAIPGLQHAMVSTEMSNAQAAVPQPTSSSPTAMQATHIRMAHGGPQDMVAPTTGTAHPLSSTMSSFTPRDPGGATPFGDPASLPGFTPSSLTESSPAFGNPQYKTPRTPYSPVEDYRDGAAIVDLQNSNRFQESVASARDRNAGSATEAHAINKDPLAKREAEDQLRLADASTAAAAAAHAAMEMDPSNRKRLAIVPNAFLPISQPEARKPLQRLAAGARANLGRKYDLLGKFASRPKTATASMTTSHANNVALPERRPSGDASRISDRGDRDSAPESDRPGTQSLTPHPGLSAARPSPSKTPSGRGQALLQLRRDRRSKPSPAFTLTTLRRSSSSRAIDGPATPRSSDDFARPGAVSGSDSDTSSSSDDNSDDAPSDSEATVMTLSPVDQASLKASSLDVITAFLSGGMQSPRSHWLGALYDAPDRSSSARSHSARPSASVPPLQGDARTDLTTGTVAALHKSSVRRWMLSRTAEWLIQNPQFRSMYCASSAARPTWPGIAIGDKIELLQSMASALSIAPDPDASKPPIDQDSATIKAETHFAAVPTLKSLVKLSGAAANAVIADGSGAEVAEVFEPARIAVGCQGSVVEALPSALNLWDKSKLSAVSGQKHVVAKVLLTDASPAWHEEIVAWLDRLRVAFETHGLGTHVGGAHSILAVADGSESLPLSSYLDQLWTDGETWLDTLRSISSRVQLDLLQGKHVVVYTLQPSASATCGSTGFHGLLRLERDLRAMLSEQVGVLAEQLLVRVVSPTMMTESGSLGFGQQTQMVRRLAFSVYDQLARLVRRQPAKVLHGKEPGPISAVVQFPAFSLSTGSETSSAASSTAAKAGRTNFSLSWPQEPAAVTDERVLLHVGYRICRTSSGEDGVGVQMDKTPSRNGSAASIDAAGVFGLDKPMDAEDRAPTKQESVVMVSAIDERGGSSSVDALAANDGDSSIEACVDRVWQFAVGEASRARVQWRLIVSSTGPMSRREKQAWERLIEAYWASTVAGNRVMGSVMLMSARPDESGAILAERGARAKVNQEWSATASTDKSSLMLLDAADFSQAVNFAEPMPMAWTQAVDGSETADEGSEYGEEDKLDEEITAMPIASAILMHHPRPELSNGVGNAGGRSHDGLGKHRLDGSTSTSHVMAVDLLQVWPAPATLQTDAQAQVAEDAAASANNEAMDAILRSLHRLRLISQERHQLPWPYSAQPWPVASVNALAACLEGVVLRD
Length2375
PositionKinase
OrganismPseudozyma hubeiensis (strain SY62) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Pseudozyma.
Aromaticity0.05
Grand average of hydropathy-0.329
Instability index54.90
Isoelectric point6.13
Molecular weight251975.87
Publications
PubMed=23814110

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32375
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     463.63|      94|      94|    1279|    1372|       1
---------------------------------------------------------------------------
  342-  423 (64.51/21.21)	...............RAD.GSastmptSSTSHldarkAWNAAVLQVITAARQSTL.QPN..ATDASLSGSQEpLQ.PLLQ.........APLIHAnSRPSSSRsdahP.........ASL
 1284- 1381 (138.56/54.07)	QNSNRFQESVASARDRNA.GS......ATEAH.....AINKDPLAKREAEDQLRL.ADASTAAAAAAHAAME.MD.PSNR..KRLAIVPNAFLPI.SQPEARK....PLQRlaagARANL
 1382- 1471 (119.15/45.46)	GRKYDLLGKFAS.RPKTAtAS......MTTSH.....ANNVALPERRPSGDASRI.SDRGD.RDSAP....E.SDrPGTQ.....SLTPHPGLSA.ARPSPSK...tPSGR..gqALLQL
 1472- 1511 (31.66/ 6.64)	RRDRRSKPSPAFTLTTLR.RS......SS.SR.....AID.GPATPRSSDDFAR..................................................................
 2271- 2355 (109.75/41.29)	GRSHDGLGK.....HRLD.GS......TSTSH.....VMAVDLLQVWPAPATLQTdAQAQVAEDAAASANNEaMD.AILRslHRLRLISQERHQL.PWPYSAQ....P............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     535.32|      91|      93|    1084|    1174|       2
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  250-  315 (67.79/22.74)	.........QQqhA..SSPSgpssYPR...PF..............ANVAF.......PGTV......................SAPRSA.A............APNTPSAPPKS.LQRLPI.............LTTHTPTSIAKL..AFP...............................
  816-  900 (88.52/32.12)	DLH..NAQSQP..M...TPL..........................KELVAftlkvlnDANE.....................SSHAQSS..............SAYTPNDP.......DDAsvslhradrmpstRPEITPASIT.....FADFDFAMP.TVAS.................AT
  901-  998 (81.99/29.16)	SSHTLPAAGQS..VtgSSP.....LKRDYMPS..............EPVLA.......ASNTeafgqdlswtqflphqsssaiTSASASTSA............VPANPLTTLGAATAQNSA.............LDGAQPSQLD.................HR...............daGW
  999- 1085 (58.51/18.54)	LLSAGSASSRD..A..QAQE....QPRALVNP..............QSLLP.......PHTD.....................LQSESSTTMqnpqgahlaptqSTSTKRKAGEGDIF..............................................dnldllteddfsffdesAF
 1086- 1176 (130.33/51.02)	DLHPGEALSQQ..I..DQPA....LPSHAIPT..............QELMI.......AGNA.....................SSAPASSLV............AGSQPVAAPAAAILGDVA.............MDDVGQSSLDALFSAIPGLQHAMVSTEMS................nA.
 1177- 1269 (108.18/41.01)	..........Q..A..AVPQ.....PTSSSPTamqathirmahggpQDMVA.......PTTG.....................TAHPLSSTM............SSFTPRDPGGATPFGDPA............sLPGFTPSSLTESSPAFGNPQYKTPRTPYS...................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     306.72|      84|      93|    1768|    1860|       3
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 1718- 1766 (58.12/32.65)	..ANAVIADGSGA.................EVAevFEPARIA..VG.CQGSVV............EALP..SALN.LWDKS..............KLSAV...
 1772- 1860 (135.97/109.29)	VVAKVLLTDASPA.....WHEeivawLDRLRVA..FETHGLGTHVG.GAHSIL......AVADGSESLPLSSYLDQLWTDGETWLDTLRSISSRVQLDLLQGK
 1862- 1956 (112.62/70.01)	VVVYTLQPSASATcgstgFHG.....LLRLERD..LRAM.LSEQVGvLAEQLLvrvvspTMMTESGSLGFGQQTQMVRRLAFSVYDQLARLVRRQPAKVLHGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.26|      16|      95|     220|     243|       4
---------------------------------------------------------------------------
  203-  218 (29.37/17.61)	GGGGSVGASGSI.HNSA
  224-  240 (25.88/16.64)	GSFASHTRSNSMtHNTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.11|      27|      27|     542|     568|       5
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  490-  516 (35.65/19.51)	PELLKSLASLSPSAHATSGSYLLAAAS
  542-  568 (41.92/24.75)	SSLRLRLTDSLASAPTTSAQQLKTTKS
  570-  596 (39.54/22.75)	SRTRLRLGDSIVFLPQTPSRSLKKAIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.91|      22|      65|    1514|    1539|       7
---------------------------------------------------------------------------
 1515- 1536 (37.10/12.70)	VSGSDSDTSS.......SSDDNSDDAPSD
 1564- 1592 (30.81/ 7.59)	LSGGMQSPRShwlgalyDAPDRSSSARSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.41|      17|      51|     618|     634|       8
---------------------------------------------------------------------------
  618-  634 (28.81/14.98)	ASLLVRATL.SLTPSSLF
  671-  688 (27.60/14.01)	APLDRRVHLiGMVPSSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.74|      19|      63|    1965|    1987|       9
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 1965- 1987 (27.51/25.89)	VQFPafslSTGSETSSAASSTAA
 2030- 2048 (34.23/20.59)	VQMD....KTPSRNGSAASIDAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.56|      52|    1529|     128|     184|      13
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  128-  184 (80.00/63.18)	WP..RFNDTV.LDSTISTACSLAISTQLCTPPAKEatgEHAPALESSHiFEQCkPTLEAL
 1656- 1710 (80.56/47.63)	WPgiAIGDKIeLLQSMASALSIAPDPDASKPPIDQ...DSATIKAETH.FAAV.PTLKSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32375 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AIVDLQNSNRFQESVASARDRNAGSATEAHAINKDPLAKREAEDQLRLADASTAAAAAAHAAMEMDPSNRKRLAIVPNAFLPISQPEARKPLQRLAAGARA
2) ASAAAGGGGSVGASGSIHNSAGPHTTGSFASHTRSNSMTHNTAAHRRVAGINQQQHASSPSGPSSYPRPFANVAF
3) HPGEALSQQIDQPALPSHAIPTQELMIAGNASSA
4) KYDLLGKFASRPKTATASMTTSHANNVALPERRPSGDASRISDRGDRDSAPESDRPGTQSLTPHPGLSAARPSPSKTPSGRGQALLQLRRDRRSKPSPAFTLTTLRRSSSSRAIDGPATPRSSDDFARPGAVSGSDSDTSSSSDDNSDDAPSDSEATVMTLSPVD
5) SSAITSASASTSAVPANPLTTLGAATAQNSALDGAQPSQLDHRDAGWLLSAGSASSRDAQAQEQPRALVNPQSLLPPHTDLQSESSTTMQNPQGAHLAPTQSTSTKRKAGEGDIFD
6) SSHAQSSSAYTPNDPDDASVSLHRADRMPSTRPEI
7) TLQPNATDASLSGSQEPLQPLLQAPLIHANSRPSSSRSDAHPA
8) TSSHTLPAAGQSVTGSSPLKRDYMPSEPVLAA
9) VSTEMSNAQAAVPQPTSSSPTAMQATHIRMAHGGPQDMVAPTTGTAHPLSSTMSSFTPRDPGGATPFGDPASLPGFTPSSLTESSPAFGNPQYKTPRTPYSPVEDYRDG
1279
198
1088
1384
952
845
379
900
1169
1379
272
1121
1548
1067
879
421
931
1277










Molecular Recognition Features






MoRF SequenceStartStop




1) AIVPNAF
2) LGRKYDLLGKFA
1352
1381
1358
1392