Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAQDDEIDLSSIFWRAPEFLQFYGNTLNDVLIMDYFSLSPFYDKKSNNQLIKMQNIANLAQPMNLQHQLVHFVGVEFVLADSKPPDLFIIKKQYRYSPSSVRVLGVYYCLNNNIYAAPDGYSTLGIKFHSAIFALQSSMKSIRDVLPAYNPRIGYKWDIQDKQRDKLDESEDNPLPLLRSMRSTREDVKAERERRAKVLGEQSEQEGEQQQVVVEPPTQPIPTKAANSTANTSIKKKKRKSTKSTATSRSSTPATPATPVL |
Length | 261 |
Position | Head |
Organism | Wallemia ichthyophaga (strain EXF-994 / CBS 113033) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Wallemiomycotina> Wallemiomycetes> Wallemiales> Wallemiaceae> Wallemia. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.572 |
Instability index | 56.63 |
Isoelectric point | 9.10 |
Molecular weight | 29653.34 |
Publications | PubMed=24034603 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32361 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 40.47| 11| 17| 22| 32| 1 --------------------------------------------------------------------------- 22- 32 (20.17/11.86) FYGNTLNDVLI 41- 51 (20.30/11.98) FYDKKSNNQLI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.62| 13| 17| 96| 108| 2 --------------------------------------------------------------------------- 96- 108 (23.68/16.37) Y.SPSSVRVLGVYY 115- 128 (19.94/12.73) YaAPDGYSTLGIKF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) RIGYKW 2) TANTSIKKKKRKSTKSTA | 152 229 | 157 246 |
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