<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32358

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSRLSIYEQKPPNWRLPISSTSLEYPDYQPPIPGKDEDIINQSTVRNGYTAPPAVQNETFSCHQLIIDSLQTNNVAQNLNFIFKSALDIRHTRNHPQSNYIRDGGGADAHIYFQQLASPEIPLQSLLKLPRNLKPESILNHLEQHHVDPQRSVWLVKLASRQSSNYTQLSMEWSNLLTQRLSSKLVELPIPESTSTPNGSSTTNHLNSHSWLSQFSFLLDILRAFIANGLLDSLTLHQWLLNHLKHIHLARLPLIATLALENIEAFYSSHQLSNVLVAAACRRIIELRVAHANEHLTCLARSLERIIVLTFDRFSYSFISPKLWLEFSPLFQSLLHTHSIYPEIKLRNNRLLYGNKDKAHTYTHYCPRQSLMRDINVLDSINTHTNIRALALDFFEPSNHSNARSFTDKVNTLLEWAVSDYRSSQHRCYAVATLLRFYVSLQLKLNQKPCSKDAIKHEIQHLVFVWLEGESRGRRECDIHKLLSELVRRRVFNYSLYMQHIIASGLMANPKKKAIHSNVLLNMPLFDASISVVNLRRMAMDCDVNASCEKSMENLTRNFRALLPRLYKKTESIPAITTLDLENTFSPYKKLPLFYQYRAIHSNLLPSVAAFTDAKTGESRLGVEELATIISILEYFEDYASVHALIEGLLPTINNRQVLFLLMDAIRRSWTVLVSMNAMAALTVKFIAKYDMVHSSGGQVRPLVLLLVTAREHMQLPAHLERPVQEAVSSLEKSLTTTVSSSAPPRSIADVQMLLHDNSAANAADLATTLWYRHSAHTQWGASVWEGVLDALRVGHARDIAITKHHLTCFAVFLHEVNNRAAGGLERYITASLAAHPQTLLGGELELSDAVKSIVVQMVVRRVVQTTAFIEDVYLPLMSRGVGAKVVVCLNNILLAVLAPETQPPMVLSDYQHLVTRRGKAYRQPHLARLAQVLPTLVALEVGGSGNGNECADGNPPHLSESAKNSCRALREALSAQKVFAAACMRNMDSVYDALMSRATVHTQQLSIDTLKALTSFGPADTTDCDIAALTSEANPWTFCRHKIALRIVLNYGSHAQTCRAVMSDLLPKMQANGLVKDMLRGINGRAGTELANMSFDKILRLLLSLKNAIDANWLADESRVAAEIYATVESISDVLLFHKAVLPAFDKDIYTNTVTNLTSCFHAIFAPREEALENGEVVEDSGSGSNSDNDGQSLEVLCKLLQLLLRTPDASTDLNSPYLGLGDAVLPYLLRRLTAVHDETTYDTAVAILDALPETPRKAFDAVDTANASLSSEVIRLLPPPQTPSAASQTSHTWELLDQIPESEGGDRRVQFNAPQLHKWLDARLVNDHLLHANKHIPLEYERNVPGDGLEAGPVLAYQFRRSLRTVDQIMGMNSVADVGDEGSVDADGDLAFHSNLKKRKADGEEGGLSNGSVDSLGSFAQAIIHPAQPLATTTTQARRTSHRRRITRSLLTETKPVQNYNAFVGNLVSLKVTSGVHAKRLDALCASVQSVADKIEFTSSASGFLIVKGKCDCRAKDIGKLVYDKLDRLVLDDITNASGWLLVLLVSLAQDPSTGLPAFSNDAFPLAESAAPIVFVFSVFSVSSSLPFCLLPEHPSQLVLYPASPGCARPIPQCNRVTQQTQS
Length1625
PositionKinase
OrganismWallemia ichthyophaga (strain EXF-994 / CBS 113033)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Wallemiomycotina> Wallemiomycetes> Wallemiales> Wallemiaceae> Wallemia.
Aromaticity0.07
Grand average of hydropathy-0.108
Instability index45.40
Isoelectric point6.98
Molecular weight180316.97
Publications
PubMed=24034603

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32358
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.56|      26|      27|    1188|    1214|       1
---------------------------------------------------------------------------
 1188- 1213 (43.68/31.91)	SDNDGQSLEVLCKLLQLLLRTPDAST
 1217- 1242 (44.89/27.29)	SPYLGLGDAVLPYLLRRLTAVHDETT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      11|      27|    1383|    1393|       2
---------------------------------------------------------------------------
 1383- 1393 (19.88/12.52)	EGSVDADGDLA
 1412- 1422 (20.24/12.89)	NGSVDSLGSFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      27|     198|     212|       3
---------------------------------------------------------------------------
  198-  212 (21.45/19.37)	NGssTTNHLNSHSWL
  228-  240 (24.69/14.79)	NG..LLDSLTLHQWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.89|      19|      27|    1124|    1144|       4
---------------------------------------------------------------------------
 1124- 1144 (27.88/23.99)	EIYA.TVESISDVllFHKAVLP
 1149- 1168 (31.01/19.79)	DIYTnTVTNLTSC..FHAIFAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.36|      31|      31|     737|     767|       5
---------------------------------------------------------------------------
  735-  765 (50.97/29.47)	LTTTV..SSSAPPRSIADV.QMLLHDNSAANAAD
  766-  799 (44.40/24.73)	LATTLwyRHSAHTQWGASVwEGVLDALRVGHARD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.65|      25|      30|     904|     932|       6
---------------------------------------------------------------------------
  904-  932 (39.07/36.00)	PPMVLSDyqhlVTRRGKAYR.....QPHLARLAQ
  935-  964 (37.58/23.11)	PTLVALE....VGGSGNGNEcadgnPPHLSESAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.31|      30|      32|     994|    1025|       8
---------------------------------------------------------------------------
  994- 1023 (47.31/23.84)	ALMSRATVHTQQLSIDTLKALTSFGPADTT
 1029- 1058 (49.00/28.85)	ALTSEANPWTFCRHKIALRIVLNYGSHAQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.91|      14|      32|     150|     163|       9
---------------------------------------------------------------------------
  150-  163 (24.80/16.83)	QR.SVWLVKLASRQS
  179-  193 (20.11/12.04)	QRlSSKLVELPIPES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.59|      16|      31|     552|     568|      11
---------------------------------------------------------------------------
  552-  568 (24.12/18.24)	MENLTRNFRAlLPRLYK
  581-  596 (29.47/17.75)	LENTFSPYKK.LPLFYQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32358 with Med12 domain of Kingdom Fungi
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