<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32355

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPSRPAIALTYGKDGFDTIAYHLYHTKCDTTADITDSARCQKVLEHVQRVEASLREQRYLVAADLSTCALWGFGHVDRRISLGSLEQQISSLRTDDCFHNRATQGEVKATEFNKLGYKDWAINNAAMLSALQGGSRSHQTANVRIVQANNSPSAQSYGSSLQQQLESLTSIYEFFTAAVIGTASYYLARYNHVTPLNARTFIAIPPPDPDLDEHAYRHFEHPRWLTALHVQLTTAGTLVITSSTDIEHPVYRLADTRKVNSTFKPDNRLVRIAPSGALVTLVEPAPPSTLGYHPASSKQPRKRSRAQRPEDWSHHWKTAVNAWLERKGIFLDGTEEDEDWVRVRLPSHVLPSDTDNSPTPQLSNQPVLWPASLCFYYHQEDAQSKFLDSTGSAQENGLEWFQTSHQTGFQDPLSFAKQWILGKAEREKALEDREKAEEAEEEAARDQTEQTQLEPSSPFQPRSTALADIKTASGVYPTPPDGIPFHGPVGPASGEASTPLQFNRAPITPAQDHLDTDHAKESIQTQDHAFERPMSLDLHSPSHDHTDDLFGDMDDDTYGANDVTDMDFDFFDDSAADKDDAAALDALVEQELAVGGELESTNHAQIQDSATENAASYEQLTNDMRSPSAPAPVRTGVPAPPQAITAQEKPLFISRSSGMVPGAATECDSSSKTTVMTITTEPTPPLSPLAVKRKLYPSPKMFEPGEAKNLDGVTRTAPRHSAFDPLKFNRKLSLSDAKYGADGRFSFASPKQPSDDHATQVGLEQEGASLGLDDSLIRLPAKLKTPLSSSIIPRIDSTAPPSTTRRTNTIPDNDVLDDSENDFTDVTSGSSSEDSSDEDAENSRAAHIHPHTSTGKRKREVRQGSESSACSSPAKSDSRTEGADSEQNAQAIRNPVRILGFLEPDAADWSLAGFVAPAVAPPKSLAQSSSFMDAVSPMNLSTPITDIQQDRVLLGPALTGEDLTHIAQILADQVILSTLDLLEDEKARFADPAEIVPECPSFNPSESVVAGIRSVFREAELRDFGEYATLKDAVSERTQQSKTQPKPVPRRHASSSSQPGEDDNYKVKNMMHYIRPPHIRVSRAEETWELSPPAIAFWDVLGLGPVSGQKNVEAYCVYPLSDDLHEPAENFLSTMSLVYESCRLGAHIRANGPGQLSETVSAENGLVAIELQEEASFQSVMRAVNEVFETLGKAWSAPDYDRGEAKIDAIVIYLINPFKTSRAFWNLCSAFWTLFNVYRQGCQAQPEVGPKPDLVLQVVPIKYIASFQELIVLDPNTYFRLAREVYDRCPPSAPPADRSSLSIYGAASIQLEEPVPKSIPFRLQADPPSDLLHENSYMHVGYACSIDDDWITVAWTDNTGKYQATVSYCLWGGRTFADIAREIWEATIEIMQQRRVTWRLCIARAGIMSREELDTWIAIVQSPCPLSVAIAILAVDPTPPLELTMDFPLPPVPKDTPAPAPLSASTPATPNQPAPSPSTDLPHGFGTPAATAPTSTATPSETAQPAPDSTTDPDARLTDATDDTYAVILGHRLNTLQSLTDYRPALASGFLVKRGVVGSEAGRNLAHDSEEPPRWPRGPIAVGVNLLVVGEVGGRRTQAGAAAATASQDGNGGVSTAEASQWARSPEAVLKDALGIYRGLGLLARLRGMRGTRHGAVPWHVVAATRGVKGLEGCWRGVG
Length1679
PositionKinase
OrganismConiosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Coniosporium.
Aromaticity0.07
Grand average of hydropathy-0.449
Instability index50.67
Isoelectric point5.05
Molecular weight183064.60
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32355
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.43|      31|      33|    1456|    1487|       1
---------------------------------------------------------------------------
  284-  313 (47.96/16.47)	.P.APPSTLGYHPASSKQPRKRSRAQRPEDWS
 1456- 1486 (60.79/22.75)	TP.APAPLSASTPATPNQPAPSPSTDLPHGFG
 1487- 1513 (37.68/11.44)	TPaATAPTSTATPSETAQPAPDSTTD.P....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      17|      29|     502|     530|       2
---------------------------------------------------------------------------
  485-  501 (31.57/10.97)	F.HGPVGPA.....SGEASTPLQ
  502-  524 (19.78/19.05)	FnRAPITPAqdhldTDHAKESIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.40|      15|      29|     534|     548|       3
---------------------------------------------------------------------------
  534-  548 (28.70/18.31)	MSLDLHSPSHDHTDD
  566-  580 (27.70/17.37)	MDFDFFDDSAADKDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.53|      20|      33|     825|     844|       4
---------------------------------------------------------------------------
  825-  844 (33.10/19.63)	DVTSGSSSEDSSDEDAENSR
  860-  879 (34.43/20.75)	EVRQGSESSACSSPAKSDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     372.08|      87|     321|     358|     444|       5
---------------------------------------------------------------------------
  358-  444 (148.68/86.81)	PTPQLSNQPV...LWPASLCFYYHQEDAQSKFLDS.TGSA.Q......ENGLEWFQTSHQTGFQDPLSFAKQWI..LGK...AEREKALEDREKAEEAEEEAA
  582-  658 (90.58/49.68)	................AALDALVEQELAVGGELES.TNHA.QiqdsatENAASYEQLTND..MRSP.SAPAPVR..TGV...PAPPQAITAQEKPLFISRSSG
  682-  768 (107.49/60.48)	PTPPLSPLAVkrkLYPSPKMF....EPGEAKNLDGvTRTApR......HSAFDPLKFNRKLSLSD....AKYGA..DGRfsfASPKQPSDDHATQVGLEQEGA
 1154- 1194 (25.33/ 7.97)	..............................GQLSE.TVSA........ENGLVAIELQEEASFQSVMRAVNEVFetLGK...A....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.32|      51|     136|    1057|    1122|       6
---------------------------------------------------------------------------
 1057- 1113 (81.79/66.82)	SQPGED.DNYKVKNMMHYIRPPhIRVSRAeeTWELSPpaiAFWDVLGLGPVSGQKNVE
 1196- 1247 (88.53/52.53)	SAPDYDrGEAKIDAIVIYLINP.FKTSRA..FWNLCS...AFWTLFNVYRQGCQAQPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.10|      25|      77|      81|     105|       7
---------------------------------------------------------------------------
   81-  105 (45.72/32.48)	SLG.SLEQQISSLRTDDCFHNRATQG
  156-  181 (39.38/26.86)	SYGsSLQQQLESLTSIYEFFTAAVIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.24|      40|     541|     780|     823|       9
---------------------------------------------------------------------------
  780-  823 (59.69/51.86)	PAKLKTPLS....SSIipRIDSTAPPSTTRRTNTIPDNDVLddSENDF
 1294- 1337 (65.55/42.35)	PPADRSSLSiygaASI..QLEEPVPKSIPFRLQADPPSDLL..HENSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.53|      15|     541|     449|     483|      10
---------------------------------------------------------------------------
  449-  465 (19.32/10.75)	EQTQLEPsSPFqPRSTA
 1039- 1053 (28.20/11.21)	QQSKTQP.KPV.PRRHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.69|      15|     541|     958|     990|      15
---------------------------------------------------------------------------
  942-  956 (26.97/18.36)	TPITDIQQDRVLLGP
  964-  978 (24.72/22.83)	THIAQILADQVILST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32355 with Med13 domain of Kingdom Fungi
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