Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDAILDTHFQRVEAALNTLVNSITSYNPSEKAADDLVAADDQLLQGLEQLATHQANHQRILHLRQTADALTAQAKSKLRSLADARKELINTPVSTFPASSKDVPFDELLSYAKRIAKFTLPPNYRPAPSPPKPSAPDATPKPPDDTQLANGTSGTPAVADSAIAAAPNPDPQADLPKDEGVALATLTREQRDWLDSMSHTPFVPWPSEAVIQRGGLMEIQRMLERGRDPAAVLPPEEQEAEERRRAEEEESRKREEEEEEGRRREAWAAQSARRGEGQGAVFGGLDLYDPEEDE |
Length | 294 |
Position | Middle |
Organism | Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Coniosporium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.785 |
Instability index | 65.28 |
Isoelectric point | 4.75 |
Molecular weight | 32322.33 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32351 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 37.65| 10| 37| 127| 136| 2 --------------------------------------------------------------------------- 127- 136 (21.10/10.27) APSP.PKPSAP 166- 176 (16.55/ 6.44) APNPdPQADLP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 46.97| 14| 15| 7| 20| 3 --------------------------------------------------------------------------- 7- 20 (23.26/16.23) THFQRVEAALNTLV 24- 37 (23.71/16.69) TSYNPSEKAADDLV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.08| 13| 15| 39| 51| 5 --------------------------------------------------------------------------- 39- 51 (21.24/14.66) ADDQLLQGLEQLA 55- 67 (22.84/16.26) ANHQRILHLRQTA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DELLSYAKRIAKFTL 2) GAVFGGLDLYDPEEDE 3) REEEEEEGRRREAWAAQSARR | 106 279 254 | 120 294 274 |
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