<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32350

Description Uncharacterized protein
SequenceMKQDKAVEALAIQTPHEATRFPSGKNVDFYPWTGEHAEDSISEHVIRSGYFEQQKPNLNESQTARPSLWGHLKNKSGLHTMSSLLVALLEKRQATGRVSATSTFKPPPRVTFKDKKREEWLHELAKPAVALRLLSRTIPHGIRGKGLLEQCLSKNIPSSRAVWLVKCVGANEMRAFKRKGYAGVMGSAGELKWIREWTTHVEQFVDNVVEADCDGTWKARMTYTIRLASHLFSERLVDHDHYLNWLLASFERSGLDRIPIWLLLIRIHWDDLVSRRQRGWCLAEGLLHHLEMATRHDNSEAYAPIAHEIRRLVACLIVRHPKCLIAPKVFGKHKHLLVLIADQDPTLECALRLVERRNARISPQDSRLAHPLSPKKRLVDYLDAQKHVSELAGLVSDILGMVPHWEQAAEVVLHWASSAYRQGHHRLYLATGLLRYWRSKGFDTDGLLLRYLSRADQRLDIEERNLFRIVVELAWTKDFFVGRYLRFLISIGAHEVGRFTADAIPCITRLIFEFSFFDLPPPTLYLRNNIVDGIGHTDEADSELLAAAKTFIAQHVPTFSGSLSKSSRVDYVTSSKLTHSARLKLSRWLRAELLNRTTKSDLQTANSGLAAYELVEGEGYQGDNPGMVPLLLRLTGEQFKFVRDVIEQLEDFSVLVDILEVAVNSSNPTVLCTIAETLADHEEVFSIMGAFGPVSRKLFARCTQEDAEDLIDREVYQALSELSCRVDTDVEVIQQLSGHMVRCGQKNTNPVCSPASEHTFELPTDIEAMSDEAFEWMAKNATGVDEHKFRQIFDSLIARTCTQRAKNERANTAPAPLFRRLRHLNSQLFNQLLYGWFSGCSQHTYGNNMRPVVSALVAAGCLDLAEFVRFANGRTAEVIVRDAPNGAMFALRALEAVLPSEHASELGKVQDVYRCRLARQAFCRNPNSGFLELVRTVLNSQDVAAYQATPCELLRSRRLLSALRQAVLDDAHKFATVFGIGSNAKASLSISKMVQDLTNGNENLSASKAVRLRRIVESVDEISLPFCQLQLRQMLAEDGPSSETTESETVNALFEAISGLLDKDQSLASLLLGSLEQSYLRKIGDVAKWKVLSAVPNWSGEVDASALPPSGPSFRMDKTTIKKYLVIVHYSTSSSKDDDTQFTSALMQKLRTLVGTLVPKKDANGELKSQERGGTTPADKDVDEVNTWIRTLLDLVIAYEGPFRSTTSGSSQLMNLLYTTSATADAQAQMQKIYAHNVLWDTRLSSIFGSSPDPDGWLSLSSSPHLLAERTSNPKATTSTEEGQKSHVGVRSQQGRSMAGAPPTSLPVSQGGTSHQQHNPPAAGQQSSGSSTQRTTSFVLRRWEILPDSSSNTGANDTALNLGLFGARKV
Length1370
PositionKinase
OrganismConiosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Coniosporium.
Aromaticity0.07
Grand average of hydropathy-0.281
Instability index40.87
Isoelectric point7.98
Molecular weight152666.75
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32350
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.15|      62|     217|     324|     403|       1
---------------------------------------------------------------------------
  108-  164 (65.69/27.91)	PRVtFKDKKREEWLHELAKPAV..ALRLLSRT....IPHGIRgkglLEQCLSkniPSSRAV.......WL.........
  219-  255 (33.41/ 6.85)	.................................ARMT.YTIR....LASHLF...S.ERLVDhdhylnWLLASFERSGL
  327-  391 (99.06/82.39)	PKV.FGKHKHLLVLIADQDPTLecALRLVERRnARISPQDSR....LAHPLS...PKKRLVD......YLDAQKHVSEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     511.39|     180|     223|     667|     889|       2
---------------------------------------------------------------------------
  676-  889 (262.71/278.22)	ETLADHEEVfSIMGAFGPVSRKLFAR...CTQEDA..EDLIdREV........YQAlselscrvdTDVEVIQqlSGHMVRCGQKntnPVCSPAseHTFELPTDI..EAMSDEAFEWMAKNATGVDEH.......KFRQIFDSL..IART.CTQRAKNERANTAPAPLFRRLRHLNSqLF.........NQLLYGWFSGCSQHTYgnnMRPVvsalvaaGclDLAEF..VRFANGRTAEVivrDA....PNGAMF
  895- 1114 (248.68/164.63)	EAVLPSEHA.SELGKVQDVYRCRLARqafCRNPNSgfLELV.RTVlnsqdvaaYQA.........TPCELLR..SRRLLSALRQ...AVLDDA..HKFATVFGIgsNAKASLSISKMVQDLTNGNENlsaskavRLRRIVESVdeISLPfCQLQLRQMLAEDGPSSETTESETVNA.LFeaisglldkDQSLASLLLGSLEQSY...LRKI.......G..DVAKWkvLSAVPNWSGEV...DAsalpPSGPSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.46|      14|      35|     437|     452|       4
---------------------------------------------------------------------------
  437-  452 (18.76/17.98)	WrSKGFdTDGLLLRYL
  475-  488 (28.70/15.81)	W.TKDF.FVGRYLRFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32350 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSLSSSPHLLAERTSNPKATTSTEEGQKSHVGVRSQQGRSMAGAPPTSLPVSQGGTSHQQHNPPAAGQQSSGSSTQRTTSFVLRRWEILPDSSSNTGANDTALNLGLFG
1258
1366










Molecular Recognition Features






MoRF SequenceStartStop




1) TSFVLRRWEIL
1336
1346