<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32349

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDNEYNMENPDTMDDLFGEGEQFSLAPGAASVPQMPVKGLAERLDELHTSGCCQRIAWSKLGCVASVTRDGREVEFRSLIRHPEDGRWELSKKQSLRLDYAHEGSYIAHLSWGLMGTDLAVVDNSGRISLFTNTFTFVLGRMQAMVKNSISEPESELSAVVGLHWLSIIPHFQKRVLYHTADRSGDEWNFCMSFHQSFDAHNPVLSKAALIYTTRSGTVKLLYQPSKDSSQWREATTELPGFSSVQDLLTHAAFAPDNDGSLLLAVHNASQHLHLYRTTVSWNPVYGQSPNPKIPPPVNSVTPTLDAVLLKREDGCAPLDLLPQVEDPASNPVDNVTVPAQLTHLQCVPAAPDYGRGPTTPTIVAIFSSNPNPYSALDHITPHQQSFSTIARWEIQQIAETSLHSGFDLLTNKRKSTSSFGGRRLCRLARQPDVPTSAIILSTSSMMQPRILACQLSDGSIEFRDRTLMDLINPDYADNSVDSFPQTGFSFPLAEPGAGYLAFSPNMCIAAAIQEDGSLILRRLEYSLSSLNIAEKNHNIDAAIAAIVLQHSNACTQYQTSDDIFASVAQDLGPARTRQLLSQVYQAMSLNLDFLTNEKEHATTLLKGAALGKCLSAQSLLRDPADEATRTLSGKLAWCILNMRSHAFVFLQMFRPDQPPEPDLAKSLVGLVKWSNDFLVYIVDELMELARAVRGQEHDRAFVQEKVNAANSPALLLLLASAPRYLLRMLLRPLQLCFKTVHAALKQPSLPRAQKAVYETLNNIFITNPISCPRFEHIVPGEVDKAVRDAYTAAKLSTEQRGAAEKAMLVNAEIPECLMPAVRQLLTGTLPKLLSELQDTSKIYFADLKWLGLHDGWMTREFARHRAVDVVRKVPLAREKKLRMCTRCGAVMEDLAPPAEGRNELGWLMFAQKSCVCMSNWVAVGEGKGDA
Length931
PositionTail
OrganismConiosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Coniosporium.
Aromaticity0.07
Grand average of hydropathy-0.184
Instability index43.13
Isoelectric point6.08
Molecular weight102987.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32349
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.82|      15|      29|     374|     388|       1
---------------------------------------------------------------------------
  374-  388 (27.90/19.14)	YSALDHITPHQQSFS
  404-  418 (25.92/17.26)	HSGFDLLTNKRKSTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.40|      48|     106|     694|     746|       2
---------------------------------------------------------------------------
  694-  746 (70.69/59.43)	RGQEHDRAFVQEKVNAANSPALLLLLASA.PRyLlrmlLRPLQLCFKTVHAALK
  801-  849 (76.71/49.23)	RGAAEKAMLVNAEIPECLMPAVRQLLTGTlPK.L....LSELQDTSKIYFADLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.71|      21|      29|     506|     529|       3
---------------------------------------------------------------------------
  506-  529 (30.70/30.44)	NMCIAAAIqedGSLILRR....LEYSLS
  537-  561 (31.01/20.99)	NHNIDAAI...AAIVLQHsnacTQYQTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.12|      15|      30|     170|     185|       7
---------------------------------------------------------------------------
  170-  185 (24.90/21.81)	PHFQKRVLYHTAdRSG
  203-  217 (26.23/17.11)	PVLSKAALIYTT.RSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.54|      26|      33|     288|     318|       8
---------------------------------------------------------------------------
  288-  318 (35.05/37.15)	QSPNPkIPPPVNSVtpTLDAVLLKREdgCAP
  324-  349 (47.49/28.31)	QVEDP.ASNPVDNV..TVPAQLTHLQ..CVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.47|      15|      33|     624|     638|      11
---------------------------------------------------------------------------
  624-  638 (26.08/17.03)	PADEATRTLSGKLAW
  660-  674 (26.39/17.33)	PEPDLAKSLVGLVKW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32349 with Med16 domain of Kingdom Fungi
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