<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32337

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSASQNKRQRTSGSFSPASPPYHLAKPPTEETKTPVVHPRTPTSPPYMSSAPPSYAYSTTSPTFQQMELSPPLSAAMASQNSQQPVVTAATSFPTPADSITDNALSTIRDGDGDAQMQDTPVDDGTKASGEDTEMTDLRDHRHSNHDRQGVSTSASGRRVGLERLDADLGSLYKLCEKPHPVARPHGAQNLIALYGLEQIAASVARKDPVTGEKINKLRKSYEGQIKRLQIGGKNKAVVEEGQFMNMLIYPDFEWHVQKVQGKEMTNPSALLSKLDRALQMGSGKLPPSEDAKWKGIIAQEEAPKPKPLVDAKKGAVGQVGGRASPAPSPLIKPSRPERTGTKRRYDDASYEGYEGYGDDAATESAGGEDERWGGGAKKKRRKEYGQAGSPLAGNYNAPPVGVRR
Length405
PositionHead
OrganismConiosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Coniosporium.
Aromaticity0.05
Grand average of hydropathy-0.855
Instability index54.43
Isoelectric point9.06
Molecular weight43674.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32337
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.94|      23|      24|      17|      40|       1
---------------------------------------------------------------------------
   17-   39 (44.68/20.19)	PASPPYHLAKPPT..EETKTPVVHP
   42-   66 (39.70/18.09)	PTSPPYMSSAPPSyaYSTTSPTFQQ
   70-   87 (21.55/ 7.25)	..SPPLS.AAMAS..QNSQQPVV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      15|      17|     285|     300|       2
---------------------------------------------------------------------------
  285-  300 (22.05/18.76)	KLPPSEDAKwKGIIAQ
  305-  319 (26.55/15.80)	KPKPLVDAK.KGAVGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.79|      19|      24|     163|     185|       3
---------------------------------------------------------------------------
  163-  185 (30.90/27.70)	ERLDAdlgsLYKLCEKPHPVAR..P
  189-  209 (27.90/15.34)	QNLIA....LYGLEQIAASVARkdP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.95|      22|      28|      95|     118|       4
---------------------------------------------------------------------------
   95-  116 (38.96/31.41)	TPADSIT.....DNALSTIRD...GDGDAQ
  120-  149 (29.99/15.31)	TPVDDGTkasgeDTEMTDLRDhrhSNHDRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.83|      11|     160|     212|     225|       6
---------------------------------------------------------------------------
  212-  225 (11.50/19.16)	GEkiNKlRKSYEGQ
  233-  243 (19.33/12.93)	GK..NK.AVVEEGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32337 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSASQNKRQRTSGSFSPASPPYHLAKPPTEETKTPVVHPRTPTSPPYMSSAPPSYAYSTTSPTFQQMELSPPLSAAMASQNSQQPVVTAATSFPTPADSITDNALSTIRDGDGDAQMQDTPVDDGTKASGEDTEMTDLRDHRHSNHDRQGVSTSASGRRV
2) SEDAKWKGIIAQEEAPKPKPLVDAKKGAVGQVGGRASPAPSPLIKPSRPERTGTKRRYDDASYEGYEGYGDDAATESAGGEDERWGGGAKKKRRKEYGQAGSPLAGNYNAPPVGVRR
1
289
160
405










Molecular Recognition Features






MoRF SequenceStartStop




1) GEDERWGGGAKKKRRKEYGQAGSPLAGNYNAP
2) KWKGIIAQ
3) PYHLAKPPTEETKTP
4) SYEGYEGYGD
368
293
21
350
399
300
35
359