<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32336

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSELPKMSDLARQPSPKSSPRGSRSPAYPRQDSSGTLKTTITLGKNPSVFHSGLFYLMKEPPDQSELTGSTNLMSYHGLEHSYNKFSGGKKLKEELSAFLPNLPGNLDVPGIQDNSSLRSLIEKPPITGKELHPLSGSMLSGFRLHPGPLPDQCRLFNQVNQKKKKHKKHKRELKDGPLQESQDNSGEGGPDHKKVKKGKRSDEERKKRKKEKRRKKEKDKEGKVTV
Length227
PositionHead
OrganismCapitella teleta (Polychaete worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Polychaeta> Sedentaria> Scolecida> Capitellidae> Capitella.
Aromaticity0.04
Grand average of hydropathy-1.221
Instability index63.71
Isoelectric point9.95
Molecular weight25442.74
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32336
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     185.58|      38|      39|     135|     172|       1
---------------------------------------------------------------------------
   52-   94 (24.56/ 8.02)	..............SGlFYLM.KEP.PDQSELtgstnlmsyhglehsYNKFSGGKK....LKE
   96-  133 (44.23/19.87)	LSAFLpnL......PG..NLDvPG.IQDNSSL...............RSLI.EKPPITGKELH
  135-  172 (69.41/35.03)	LSGSM..L......SG.FRLH.PGPLPDQCRL...............FNQVNQKKKKHKKHKR
  174-  214 (47.39/21.77)	LKDGP..LqesqdnSG....E.GGPDHKKVKK...............GKRSDEERKKRKKEKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32336 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSELPKMSDLARQPSPKSSPRGSRSPAYPRQDSSGTLKTTITL
2) SAFLPNLPGNLDVPGIQDNSSLRSLIEKPPITGKELHPLSGSMLSGFRLHPGPLPDQCRLFNQVNQKKKKHKKHKRELKDGPLQESQDNSGEGGPDHKKVKKGKRSDEERKKRKKEKRRKKEKDKEGKVTV
1
97
43
227










Molecular Recognition Features






MoRF SequenceStartStop




1) GPDHKKVKKGKRSDEERKKRKKEKRRKKE
2) HKRELKDGPLQESQ
190
170
218
183