<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32325

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSHPSTAQNGCSLEDCHTNLFALTDLTGIKWRKLTASAFPVDPLDDPVLVSFTRCMQSDILCAWRRVPRNNPGPLVELMCTKELWIFWYGDEPINLRSLLSTDLQGTSLLNFPNPLTPSLSFAESEQGSWDNGLYYECRSILFKALHNLIERCLLSQHFVRLGKWFVQPHGHTGPLSLAEKSNHLSIRFSFFLHGESTVCASIDVRQHPPLRTLHPSHLVVAPQTPHPGLQVILAPYGLAGTLTGVSCKDTEPSTQRMLDEWRQFYVLQETETCGQGDNRLPMMVEVVVAGVRMKYPSCFVLVSADTEADLIHMHGAPFSQSLQQSAPQQAPSAPLQSYATGPPTTSPVTPGPGSVLGSSQSGADSKAPPPLLEYNDVFEPLMEPDVGSALGHRLFEKVWQDSTITCGLHLNMRQQQQQNQVVEIGGANAEEQASWDYGDPMQKNSCMCSSCLSPNMPGKYKSDKEKAEKEKHRPHSRGPLSFHRRSAVYDEMFSHDADFQQQQSSAAPQLPSTFSTPAATASADSPHSGGAPSPLAAPQVAGSANQNNADMTMPTLSPHPPSKNAADKEPSDQHAVIASSAPANTHVGSVTPWLDSQLLKHSRPMAFKRPALPINGYDQAHTELVTESLYNFKSLNDWSVMDQPVKKIKLELEHPSRPSSNGLNPFDNPPLSHDNSPLPQSMPLDPYEFSDESSSNAGSAFANKANRRQSRDDSFSRPSPFGIKQVSINNISTSLTSESGLRPSITDLEKLFDTDESESSDADLATAPSPPGKSSDENKASCGGKSLASSNAHGSGPTPHELAKMFPTPPSLENQHNASSPPQDVSNGPMMPSGDHLDHRTMLVKEPHMPRSIPHAHVSDWSFVNRPPTACMFLGSSKYSPVELPSGRLDPLAYPLGTPDTTIYKPSWTHSQYLNVPSIDNPGSVSGGRVQDTSPANASFHGMARTPRTPMSYELHSPASNASSYLNQNMKSVDNHMHTSQLPEVHALVVNIYLSDSLLNLFKDSNFNSCPICVCNTNIKGADIGLYLPDRNNEPQFRCMCGFSAAVNRTYGYNSGLFYEDEVDITGMKHDRFDRRKASLLVLEDKEEKEKAALTGEVVPQDVMTLLQGQFSALYPSPIVLQTFHKQPSGYTAQDSINMLEISDGCEAVYAVLEVGRQAMENSNTHQPLSDPVARHHCLSKWPFFKTAAKVPVNSQDVVRMLKSLQPLLQDAIQKKRTARVWESVYTISGPLSWKDFHLLAGRGSEERSEPQPIPALTVSSEKDSLSIGHHAIKYWDKMMLEPFSHKRNVVYVVVAPDNDFLLEHVKRYFSELSAMYEQCRLGKHQPFTHRLRDGIMRIGKNAASKVSDEPVADWFKLIGNSTVASKLRLYAQVCRRLLAPFLSQELTEKGKVFDHTKPPRTHSSTKPVPHKEGDPTHDSDDRGDRPEGHEPASEHDVTGDILNSKNDADDVPALVVYMVEPFSYGQEWDDLKRLSMLGILRCYHDMIAGLPAMLRENTQLQIVPLRSLVDVHREGASQALKSLCLSVYSQSRRLLKYSIAGTSLTGFGPAASAETLLKQREAEKFAAFNLYTPPFILTRERKKLQLTETSIVEKTEKSGVLFCGYCLSEDQRWLLASCIDSCGELLETCVINVEIPNRNRRKKASARRIGLNKLWDFILGVISQTSMPWRLVVGRFGRLGHGELKGWAGLLSKKNLHLACRHLRDTCNMCNVLGPNEMPQITSACLVSMENHSSMHIMTDSVKMEERRSSSAQLHTPRDASCTHILVFPTSATAQAGSSERPTDNHMSLADDGLGDVFDIGDDEELLPGINDVFNIFGDDEKGNSPPGSPSHGMGGQAGMQHTRDGLPMESISEAQDDIGNLHQQPLAMGFYVSTAKTGPLPKWFWSAAPQREDLCPVVLKAALHIHLAKSQPGAANDEFGSSLSGGTASKDNHPLDSNFTCDVLRYVLETYNALSWLTVDVRTGDRRSCLPAHFVVLMQLYQALNTYI
Length1991
PositionMiddle
OrganismCapitella teleta (Polychaete worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Polychaeta> Sedentaria> Scolecida> Capitellidae> Capitella.
Aromaticity0.07
Grand average of hydropathy-0.444
Instability index54.50
Isoelectric point6.07
Molecular weight219468.02
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32325
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.71|      36|     104|     191|     231|       1
---------------------------------------------------------------------------
  191-  226 (64.79/29.61)	FFLHGESTVCASIDVRQHPPLRTLHPSHLVVAP.QTP
  300-  332 (50.79/20.68)	FVLVSADTEADLIHMHGAPFSQSLQQS....APqQAP
  796-  823 (46.13/20.26)	....SGPTPHELAKMFPTPP..SLENQHNASSP...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     400.68|     181|     346|    1085|    1428|       2
---------------------------------------------------------------------------
  604-  688 (102.87/14.52)	RPMAFKRPALPiNGYDQAHTELVTESLYNFKSLNDWSVMDQPVKKIKLELEHPSR.PSSNGLNPFDNPPLSHDNSPLPQSMPLDPY..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1063- 1181 (102.98/73.08)	......................................................................................efsdesssnagsafankanrrqsrddsfsrpspfgikqvsinnistsltsesglrpsitdleklfdtdesessdadlatapsppgkssdenkascggkslassnahgsgptphelakmfptppslenqhnassppqdvsngpmmpsgdhldhrtmlvkephmprsiphahvsdwsfvnrpptacmflgsskyspvelpsgrldplayplgtpdttiykpswthsqylnvpsidnpgsvsggrvqdtspanasfhgmartprtpmsyelhspasnassylnqnmksvdnhmhtsqlpevhalvvniylsdsllnlfkdsnfnscpicvcntnikgadiglylpdrnnepqfrcmcgfsaavnrtygynsglfyedEVDITGMKHDRFDRrkasllvlEDKEEKEKAALTGEV.........VPQDVMTLLQ....GQ.FSALYPSPI..VLQTFHKQPSGYTAQDSIN.MLEISdgceAVYAVLEVGRQAmeNSNTHQPLsdpvarhhCLS
 1201- 1285 (93.02/308.12)	RMLKSLQPLLQ.DAIQKKRTARVWESVYTISGPLSWKDFHLLAGRGSEERSEPQPiPALTVSSEKDSLSIGHHAIKYWDKMMLEPF..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1414- 1528 (101.81/ 0.00)	............................................................................................................................................................................................................................................................................................................................................shkrnvvyvvvapdndfllehvkryfselsamyeqcrlgkhqpfthrlrdgimrigknaaskvsdepvadwfklignstvasklrlyaqvcrrllapflsqeltekgkvfdhtkpprthsstkpvphkEGDPTHDSDDRGDR.......pEGHEPASEHDVTGDIlnskndaddVPALVVYMVEpfsyGQeWDDLKRLSMlgILRCYHDMIAGLPAMLRENtQLQIV....PLRSLVDVHREG..ASQALKSL........CLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     531.42|     114|     355|     477|     593|       3
---------------------------------------------------------------------------
  334-  394 (67.30/26.39)	...........................AP.....LQSYAT.GPPTTSP..VTPGPGS......VLGS.SQ...........................SGADSKAP.....PPLLE..YNDVfEPLMEPDV..GSALGHR.............................................................................
  396-  498 (103.71/45.81)	.FekvwqdstitcglhlnmrQQQQQNQVVEI.....................GGANAEEQASWDYGDPMQ...........................KNSCMCSSCLSPNMPGKY..KSDK.EKAEKE...............................................khrphsrgPLSF......HRRSAVYD.EM.....FSH..DA
  499-  593 (156.52/72.46)	DF..................QQQQSSAAPQLPSTFSTPAA.TASADSP..HSGGAPSPLAAPQVAGSANQ...........................NNADMTMPTLSPHPPSKN..AADK.EPSDQHAVIASSAPANT..HVGSVTP....................................................................
  689-  862 (100.38/47.69)	EF..................SDESSSNA...GSAFANKANrRQSRDDS..FS..RPSPFGIKQV..SINNistsltsesglrpsitdleklfdtdesESSDADLAT.APSPPGKS..SDEN.KASCGGKSLASS...NA..H......gsgptphelakmfptppslenqhnassppqdvsngPMMPsgdhldHRTMLVKEpHMprsipHAHvsDW
  863-  948 (103.50/45.08)	SF..................VNRPPTACMFLGS..........SKYSPveLPSGRLDPLAYP..LGTP..............................DTTIYKPSWT.HSQYLNvpSIDN.PGSVSGGRVQDTSPANAsfHGMARTP....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.00|      52|    1436|      97|     149|       5
---------------------------------------------------------------------------
   97-  149 (87.15/52.27)	RSLLSTDLQGTSLLNF.PNPLTPSLsFAESEQGSWDNGLYYECRSILFKALHNL
 1534- 1586 (81.85/45.00)	RRLLKYSIAGTSLTGFgPAASAETL.LKQREAEKFAAFNLYTPPFILTRERKKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.29|      30|     992|     962|     994|       7
---------------------------------------------------------------------------
  962-  994 (46.47/39.03)	NASSYLNQNMKSVDnhmHTSQLPEVHALVVNIY
 1955- 1984 (53.81/35.35)	NALSWLTVDVRTGD...RRSCLPAHFVVLMQLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.88|      31|    1487|     154|     188|       8
---------------------------------------------------------------------------
  154-  188 (47.63/45.06)	LLSQHFVRLGKwfVQPHGHTGPLSlaEKSNHLSIR
 1673- 1703 (57.25/37.69)	LVVGRFGRLGH..GELKGWAGLLS..KKNLHLACR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32325 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CGLHLNMRQQQQQNQVVEIGGANAEEQASWDYGD
2) IFGDDEKGNSPPGSPSHGMGGQAGMQHTRDGLPMESISEAQDDIG
3) KGKVFDHTKPPRTHSSTKPVPHKEGDPTHDSDDRGDRPEGHEPASEHDVTGDILN
4) MHGAPFSQSLQQSAPQQAPSAPLQSYATGPPTTSPVTPGPGSVLGSSQSGADSKAPPPLLEYNDVF
5) PGKYKSDKEKAEKEKHRPHSRGPLSFHRRSAVYDEMFSHDADFQQQQSSAAPQLPSTFSTPAATASADSPHSGGAPSPLAAPQVAGSANQNNADMTMPTLSPHPPSKNAADKEPSDQHAVIASSAPANTHVGSVTPWLD
6) PVKKIKLELEHPSRPSSNGLNPFDNPPLSHDNSPLPQSMPLDPYEFSDESSSNAGSAFANKANRRQSRDDSFSRPSPFGI
7) QVSINNISTSLTSESGLRPSITDLEKLFDTDESESSDADLATAPSPPGKSSDENKASCGGKSLASSNAHGSGPTPHELAKMFPTPPSLENQHNASSPPQDVSNGPMMPSGDHLDHRTMLVKEPHMPRSIPHAHVSD
407
1818
1391
314
458
645
726
440
1862
1445
379
596
724
861










Molecular Recognition Features






MoRF SequenceStartStop




NANANA