<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32315

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAAQSTQLVQLMERLRNRRPPSWNDTLRCLKSALVEKRPFAVDKSKLRCHLETLHKAFKVTDYTSMVERLELLAHRHGLKFSHDPNTAVIYLSADVLYLQVALEASGRVKMVQVSCNSEITNCPDLAKSLSNSQFESFIKHIDGLSSVSNVCTDKKLKSKLFLALQSLETDLSMLSKLQSTISSVPNYIHKSPLGILLPRNGGIAMRMVYFVGPYDLLNESTASSCPMTVEGIVDNNIGCSVTVGVESSELHKLQTMPLMSINHSPEGKSMPAFSALSSVNSCHFPAVFVLRLQKPIPVSLTVLRLIQEVTDLEVVDPSEMTSLPSLLLQHYSKHRAAEYDSTKGLHVPLPDQRHSYFLSALNGSPDLQGALVTRIPFLHPTNVPRLLQLLRMQLLFNTVIGSCISKQPLKSAELDLRDITNVRCVINPHDNQEPICPEEHASRVFQRCLSIPITMRSVLHKAKHLLKAELLRQTPPPPLPVATPPLSRTGLERRLAFIESHAPPSKMAEYNQDAMDALEGIDPVPVTPTTPLAATSSPNKMCFDKVVKNPMLASLLDQESSASPSVVSRDSQSSAPMLSALLGNDSPSSTSSNFSTSTTSTMATINKHRKQRKRRSNSERTSPVNRTPKRKPSEDDFSSSLPPMDFDFTGFDLPPSAPPSATLTPTLTTPTVNLSAEEQRANPFLQESHVSRLASSLDKIIKQESKDGEIQPECSTHAEDGRKEGGGLNHVGVEGGGGGDDVVKLETVAEAFQELSAKSFNPTDLINKTAKLHRQRSHDKDLYDFHVIKTETNYFNDNEDSQKSFTKEKQPEGTTIKIKMDVGHGVSIAMSKEKKERADTKPPITVKLNKKILKDSPLMKSEGGLDASSWQPEKKNHGTVDLTKSEDASPRILTGSLKSKRFTKEKLREKKKRSSKHNSSDRDKRKRNDEIKREELKKQKIYDFDSEINRSENFRVEKGPQKPTTIKITKVPSAASRGALVTTSVSNKSPSRTSPVVSSPSQVKVVKGVDGGREKGLSKVTSRPGQKQVYNRSKSDPQGAWGVSANASASSGSANGGSSKVDSKLTRNPSVKLKPLNLAPGGTTVTVSMPNKNSQSPISTPSTPRTAPVAPSSSKALPPPRKKGSLSAVIDKLTKQQKGPTDRKEAYDAIRLQIIREGNKPSTPTKELLEGSFKSSQGKKPGSLSGMKTIPKVPKTSSSTPSHLQNKTAQIPGRRSPSVNAKPAQAPSNNSQKPALNSIPSAIPSKAVPPTSRPNTASPKGDPSSRPKDILLSKNQPIQSPPQTELPSPSRASVPTIPLVKQTSKAQATPPPVMHSRDPRTLGPSKVPPKPSASAVTFTESPASPTPENRGPSKQEDKAKAAAAAAAAKGEDAPNRHFLDAVIKLNGTSEECEEKKTSVQPQNHVKSADDNRSKHPSLQTSAQTPKSVNSSEDKENKAAKSAADDDVFKAPTPKTAAWNGEEAERSRVDKFRSKSVLSPRSDISSPEDGLIIDVHSPATPRDPTARLRERSNSPKSPAIRSPMSADLPKSPANHLALSPSPRRPIRQGPSPQTLKPVRGSPSKSSPAVGDALDIDDDLMDAALGVV
Length1587
PositionMiddle
OrganismCapitella teleta (Polychaete worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Polychaeta> Sedentaria> Scolecida> Capitellidae> Capitella.
Aromaticity0.03
Grand average of hydropathy-0.640
Instability index61.37
Isoelectric point9.66
Molecular weight172165.41
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32315
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      22|      25|    1314|    1336|       1
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  629-  650 (24.70/ 6.42)	P.KRKPSEDDFSSSLPPMDF.....DFT
 1320- 1347 (25.90/10.52)	PrTLGPSKVPPKPSASAVTFtespaSPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.95|      25|      25|    1244|    1268|       2
---------------------------------------------------------------------------
 1244- 1268 (45.85/17.93)	I.PSKAVPPTSRPNTASP.KGDPSSRP
 1271- 1296 (29.87/ 8.73)	IlLSKNQPIQSPPQTELP.SPSRASVP
 1546- 1568 (26.23/ 6.64)	I.RQGPSPQTLKPVRGSPsKSSPA...
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.54|      23|      24|     995|    1017|       3
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  995- 1017 (39.78/19.04)	SP.VVSSPSQVKVVKG.....................VD...GGREKG
 1019- 1062 (23.01/ 7.69)	SK.VTSRPGQKQVYNRsksdpqgawgvsanasassgsAN...GGSSKV
 1063- 1087 (21.51/ 6.68)	DSkLTRNPS.VK.LKP.....................LNlapGGTTVT
 1108- 1125 (28.25/11.24)	AP.VAPSSS.....KA.....................LP...PPRKKG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     106.36|      22|      25|    1406|    1427|       4
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 1406- 1427 (34.15/16.24)	VKSADDN..RSKHPSLQT..S.....AQTPK
 1429- 1455 (24.46/ 9.11)	VNSSEDK..ENKAAKSAA..DddvfkAPTPK
 1484- 1507 (24.52/ 9.16)	ISSPEDGliIDVHSPATP..R.....DPTAR
 1508- 1530 (23.24/ 8.21)	LR.ERSN..SPKSPAIRSpmS.....ADLPK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.89|      22|      24|     551|     574|       5
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  551-  574 (35.73/20.39)	PMLASLLDQESSASPSvvSRDSQS
  577-  598 (40.16/18.48)	PMLSALLGNDSPSSTS..SNFSTS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     280.34|      86|      97|     666|     761|       6
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  666-  751 (143.94/73.32)	PT.LTTPTVNLSAEEQRA.NPFLQESHVSRLASSL..DKIIKQESKDGEIQPE....CSTHA...EDGRKEGGGL....................NHVGVEGGGGGDDVVKLETVAE
  763-  816 (55.02/33.27)	PTdLINKTAKL..HRQRShDKDLYDFHVIKTETNYfnDNEDSQKSFTKEKQPE....GTT.........................................................
  880-  974 (81.38/38.58)	.......TVDLTKSEDAS.PRILTGS..............LKSKRFTKEKLREkkkrSSKHNssdRDKRKRNDEIkreelkkqkiydfdseinrsENFRVEKGPQKPTTIKITKVPS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.24|      79|      99|     360|     448|       7
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  360-  448 (122.09/87.28)	SALNGSPDLQGA.LVTRIPFLH.PTNVPRLLQL.LRMQLLFntvIGSciSKQPLKSAELD......LRDITNVrcvinPHDNQEPICPEEHASRV.FQR
  458-  546 (115.15/61.37)	SVLHKAKHLLKAeLLRQTPPPPlPVATPPLSRTgLERRLAF...IES..HAPPSKMAEYNqdamdaLEGIDPV.....PVTPTTPLAATSSPNKMcFDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.64|      16|      19|      38|      56|       8
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   19-   34 (28.73/ 8.49)	RPPSWNDT.LRCLKSAL
   38-   54 (24.91/15.89)	RPFAVDKSkLRCHLETL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.77|      20|      20|    1194|    1213|       9
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 1194- 1213 (35.23/18.18)	VPKTSSSTPSHLQNKTA..QIP
 1220- 1241 (30.54/14.64)	VNAKPAQAPSNNSQKPAlnSIP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32315 with Med1 domain of Kingdom Metazoa
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