<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32310

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGAGTISLSTLIEYILQRTYQELTILSELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANSASKVDKCALISSFLDQQAMLFVDTADMLARMSRETLIHARLPSFSLPCAIDVLTTGTYPRLPACIKERIVPPDPITVEEKRETLSRLDQIIEHRLVTADLPRHMRRPTIANGRVKFIVPHEFMITLTLMGDGVKIPWRLLDIDFLVEDPDTGDGKALVHSLQVMYIHELVQSRLMDNDRPLHDLYNCLHSFCQSLQLEVLFSQTQRLKEQRLSENIRIEEYLAGRSLVISYWRFAHSFLFVTFAIHVDDHEPDKPLQISHFPHIQGSASIKVAMALKSDQLSMEKLLVHTIQMRSLAILEDLKREFKLLVPGPCEVRDLPTVLYVTVVEPCMDSEKLCLTVNMMTGSVLVSVDCHSTEVTNKIQECLNSDRKGLRKLLSEFRLWLGTRRCEHSMQLLQVTSQPTLPLVNLGGHPLEDLGTNVLFVKFPKEAEYYLVRCLDYKFFSLQTTAVSHEQVVDGMGATLSSDVSVPSVTGLTHPLPVHKSTAYLKAGHLMQLDAFACTQGPWAPLFDLEEKELDMLNRKRKVEPAMKRPRGSPYFVSPLVHVLASFEDKIPFIALGNELQNRGLPHQGIQLEAQGAGLALPLLQTPKCPDLNEKSNERMLSDLLSVKFRVQRKGARAWLVEVAFANCPVQSSTPREQGPVHRLYLCYDVQSPDPYPKIIQNFIDDWNALAHLYQAVLEFSEVLKENNNFQGALEIKSHNYKRITMAYGPDKCYSATVQYMTAEKQFRVALGTIGPAPVSNCHTLTLTHLQKDLNASGSLAGLAQTLIDTWSPLTAIGKITVAPQTTKPGQSMPGCAILPQSSRHVRLVFRGLFCLDLHLLSSHVVGIRDGAYSVFDTSKVVDGLLPIPGFKTFLNFYMDDTAKQVQRRSTTEDDNPPSPMGMDSIDSFMAHSTAAVHSPAPLRSIKQQQQDASKMHNPMTPPSNPCTPASPRICQPLPSPAGSNFPLASPPSLQQVITPSPSNVMAPSPGNLPVPSPSFAPTPSPSSLGMQLQSPANTFISPQAGVLSPPSRVLPQRSWAASIPTQLSHDAMHKMFSPAPPPTGSNLLAEQPLATPIERFLGCVFFLRNFKRILSAMDNLSLVPCTEQSVMQFKGESLQHRVFINPTHYQTLHLTCTPLDAFASQWDSEELQYLDKYFEAKVASGFFKVNILTGFSRLLGAPFRLLKDFVQIMRLELVTHNLTVSSTDCFVQVPEANLKWHVQWCLTVPHGISPIAGGNASPAGTIAVVMKAKILFILQLTRNTALGGEPQTIIAPILYDKSNNQTQMMDAWSNNSQAEVAISQMFQRFAEFNSNPASCSIYPAIRELLSNLTF
Length1384
PositionTail
OrganismCapitella teleta (Polychaete worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Polychaeta> Sedentaria> Scolecida> Capitellidae> Capitella.
Aromaticity0.07
Grand average of hydropathy-0.090
Instability index51.07
Isoelectric point7.40
Molecular weight154289.63
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32310
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     193.23|      35|      36|     989|    1023|       1
---------------------------------------------------------------------------
  989- 1023 (73.03/36.56)	MTP.PSNPCTPASPRICQPLPSPAGSNF....PLASPPSL
 1027- 1058 (56.30/26.36)	ITPsPSNVMAP.SPG.NLPVPSP..SFA....PTPSPSSL
 1070- 1092 (29.40/ 9.96)	ISP.QAGVLSPPS.RV.LPQRSWAAS..............
 1094- 1126 (34.50/13.07)	....PTQLSHDAMHKMFSPAPPPTGSNLlaeqPLATP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.21|      56|      72|      89|     160|       2
---------------------------------------------------------------------------
   89-  145 (93.65/78.25)	TADMLARMSRETLIHARLpSFSLP..CAIDVLTTGTYPRLPACIKE.RIVPPDPITVEEK
  162-  220 (91.56/47.47)	TADLPRHMRRPTIANGRV.KFIVPheFMITLTLMGDGVKIPWRLLDiDFLVEDPDTGDGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.16|      27|      72|     241|     294|       3
---------------------------------------------------------------------------
  241-  278 (35.80/32.60)	DNDRPLHdlyncLHSF.....CQSLQLEVlfsqtqRLKEQRLS
  316-  347 (39.36/29.11)	EPDKPLQ.....ISHFphiqgSASIKVAM......ALKSDQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.82|      16|      72|     569|     589|       5
---------------------------------------------------------------------------
  569-  586 (27.30/23.83)	QGPWAPlfDLEEKELD.ML
  654-  670 (27.52/ 9.53)	QTPKCP..DLNEKSNErML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.41|      21|      87|     699|     724|       9
---------------------------------------------------------------------------
  699-  724 (28.24/29.48)	VQSSTPREQgpvHRLYLcyDVQSPDP
  787-  807 (37.16/19.94)	VQYMTAEKQ...FRVAL..GTIGPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.44|      12|      32|     393|     404|      10
---------------------------------------------------------------------------
  393-  404 (22.55/11.06)	VEPCMDSEKLCL
  428-  439 (20.89/ 9.79)	IQECLNSDRKGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.30|      16|      97|    1129|    1144|      11
---------------------------------------------------------------------------
 1129- 1144 (30.60/16.25)	RFLGCVF.FLRNFKRIL
 1227- 1243 (24.70/11.81)	RLLGAPFrLLKDFVQIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.63|      34|      64|     441|     480|      12
---------------------------------------------------------------------------
  441-  480 (49.78/44.67)	KLLSefrlwLGTRRCEHSmQLLQ.....VTSQPTLPLVNLGGHPL
  507-  545 (51.85/29.23)	KFFS.....LQTTAVSHE.QVVDgmgatLSSDVSVPSVTGLTHPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32310 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VHSPAPLRSIKQQQQDASKMHNPMTPPSNPCTPASPRICQPLPSPAGSNFPLASPPSLQQVITPSPSNVMAPSPGNLPVPSPSFAPTPSPSSLGMQLQSP
966
1065










Molecular Recognition Features






MoRF SequenceStartStop




NANANA