<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32303

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELIYTANKTRKIFDQKVVCSLSQKNLVALSCFGELRSVNETDSQPPLKRSKQKWSTSSCSYYVYICDIDRPWDVTEIMHSPVPIVCLQWHVSGSSLLIATASGHCTVWQMKDYIINEWTKVQTVDLNGEEVLSAAWLHPGSQVNFHADQCESSSYTDKIKKAAFRPSLSSYGGKPLKGWIAVTATGLIYAAVDNEQSSEPHLSKASLMLSRKRILVADIAFSSTGEIHVAVSDGRLSSALHTFCITLLTQTDEPCLIKSKPGAGFFAKCHTDPCSKAKVSHLRFMEFEDPTTIIVGAGDGSSSQVEMWKMQHDQRDVHPLFATPDSVLRLYHWVHFSSVTHNSPASAIAVPRFPVRGSDPTLFQYVAVAYSDGLVKLVDKTRFQTVTTTNLDMTDLNEAEGKRSAYMCHMQQSFTGCVLLGLDQYGSLYAMKAVNTRDPVTQVAPSFLVGMLEYVACTHRDWWDIISVLKPAVVEGIIQQISDNLSQQSPMTKEHLQPRMLAVQRSLVKSSSTGHQQRAADFHCRFMLHSIAQLFRSLLRPKAASSQEMSAAEKLSATCAKNTESDVDKVMVGLSAENKDFVVEPATLQSLQQLMQWVGDLCLYLLTSLPSLAHGYSSFPCHTLLRDAAFLGLARELLLLIRVWTLVNPSCAPVFTSPIMDCTLLLFKLLTRLWIAAKDSTDFEDSLLDECCQLQSQVLAQPVHEGLLGDLDFGCSIFTQPQPLQLLFGQQPLYLMQGYDKIGTMLPEGQVLSLQRKDIVRLSHLGRKPPSRIRKCSRCGCLSLRKGNSVLPALRMWELRFVRCCPCGGQWSLTQHTRYVPF
Length823
PositionTail
OrganismCapitella teleta (Polychaete worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Polychaeta> Sedentaria> Scolecida> Capitellidae> Capitella.
Aromaticity0.08
Grand average of hydropathy-0.065
Instability index43.61
Isoelectric point8.01
Molecular weight91726.77
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32303
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.01|      67|     138|     525|     597|       1
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  525-  597 (99.90/71.16)	CRFMLHSIaqLFRSLLRPKAASSQEMSAaekLSATCAKNTESDVDKVMVGLSAeNKDF....VVEPATLQSL..QQ...LMQ
  663-  738 (103.12/58.09)	CTLLLFKL..LTRLWIAAKDSTDFEDSL...LDECCQLQSQVLAQPVHEGLLG.DLDFgcsiFTQPQPLQLLfgQQplyLMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.86|      68|     138|     198|     271|       2
---------------------------------------------------------------------------
  198-  271 (105.98/96.02)	SSEPHLSKAS.LMLSRKRILVADIAFSStgEIHVAVSDG..RL..SSALHTFCITLLTQTDepclIKSKPGAGFFAKCH
  338-  410 (105.89/77.17)	SSVTHNSPASaIAVPRFPVRGSDPTLFQ..YVAVAYSDGlvKLvdKTRFQTVTTTNLDMTD....LNEAEGKRSAYMCH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.27|      24|      27|     763|     787|       3
---------------------------------------------------------------------------
  756-  785 (36.26/20.12)	QRkdivrLSHLgRKPPSRIRKCSRC.GCLSL
  786-  814 (40.01/18.35)	RK.gnsvLPAL.RMWELRFVRCCPCgGQWSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32303 with Med16 domain of Kingdom Metazoa
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