<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32288

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRKMKSPLTKVSICPVPSHSSFTRKSNVCTSVEIAQHLPIYLINEEHLRMAQSSPVPFQVLISPYGLSGTLTGQAYKMSDPATQKLMEEWQYFYPVVLKKKEGFKEEQRYDDDFPVAVEVIVGGVRMVYPSAFVLIAQNDIPISPSTLAPGAHNSMAQQGAGNMKDAHSCGMFLTPPISPEQIVIGDSGSIPSMVSYSAAAPDGMGSVQGSKISEKIPSIFHKRIIQRTWKEWILNKSQSKRAPMMKGGTLTNCAAWDFIDPVKRVYCTCSRHRLFRQRYLGFCRLPSLSHSSSSTSLPFASKHKITERQEKLDKNQKRSLLPFHYRPAVTEELCTEQDPPVHKLTLAGMEPSLEASGIRKYEKPFSLPPRHSSKQSHLNPMDSPHSPASPLPPTLSPQPRGQEAESLYPPSIPVTPILYHSGLELQPLLSTEGRTVHGGQRLPLTEDVGDTGVYSGLVRNQESLNMWQGYTLPSSGNTEFRPPELHCERYDIHVNTPFQSTALKRLLAQPNKRFKIVEEPSSVPAMHYFDLYPLNRRRPGKGLRDVSDPYTFQDGDIKYSFTRAKKGKLGADREFLKKNKSDDGTGPKDISVAGHSTSMSDGKDAMSIFRSAPKTDTRHDNAATRAGSSSLMQVTDLAPSLHDLDNLFDNSDEDDNEAVSPSHCSKVPLQGTEERSLAKDTRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMCYKDGIGSETLTTLGMLESPAFSMTTNQLTEFKIEVEDGLGSPKPEEIKDFSYVHKTSTFQPFLGSSAFAPLKMLPSQCLLPLKIPEACVYRPSWALPPKTEHLSLPPNTTFIRDGYTNIPSVGSLADQDYLQMNTPQMSTPVTLNSVAPASNGGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTSRPLNSVEPATVQPILEAHSLYVTLILSDSVLNIFKDSNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIVNRKLGYNSGLFIEDELDIFGKTSDIGQIAERRLMLSQSPLTPQLGEGSKKVQEFPISLLLLLQSQHTQPFTSMNCLYYMSATNRQTLPSTNWNYDRVRAESNDSWVECFNALEQGRQYVDNPIGGKVDEALVRSATIHSWPHSNVLDISTLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWETIQHVQGPLTWQQFHKMAGRGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGRQDVAYIVVCPENEALLNGAKTFFRDLSTVYEMCRLGQHKPICKVLHDGIMQVGRTAAQKLTDEVVSDWFNAPWGSEDTDNHSKLKLYAQVCRHHLAPYLATLQLDSSLLMPPKQTTPSSQERTKPGRPMVPSHSTPFAVPGPPPVGSSFTSTPSARTTNLPVGSSSAPRLSASSLAPSIKPANTTSSSGFSSGLPQGQNLAAGANPTERSQGSSLSGGDTEAGHSSSQQNQEGTESTAERERMGVSLDPEPVDSHAYPPAVVIYMVDPFTYTAEEESASANFWVLSLMRCYTEMMDSLPEHMRDSFILQIVPCQNMLQTTKGEQVLYLQHLKSLAFSAYCQCRRPLPTQNHIKSLTGFGPAANTETTLKNPEWPSPIQLYSPPFILAPIKDKQTELGETFGEASQQCNVLFVGYCLSHDQRWLLASCTDVHGELLDTCVINIYLPNRSKRSKVSPRKIGLQKLWEWCTGIIQMSSLPWRVVIGRLGRLGHGELKDWSILLGESSLQTISKQLKEVCRMCGISSTDSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPNNDDMFDLPFPEDMDNDIGILMTGNLHSSPTSSPVPSPCSPGVGVGPSFQHSRSQGERLLSREAPEELKQQPLALGYFVSTARAENLPQWFWSSCPHAQNQCPLFLKASLHHHISVAQMDELLPPRNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNLLS
Length2042
PositionMiddle
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.07
Grand average of hydropathy-0.387
Instability index59.10
Isoelectric point6.38
Molecular weight224934.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32288
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.61|      21|      27|     851|     872|       1
---------------------------------------------------------------------------
  867-  894 (27.72/13.01)	SNGGAG..........vlpspaTPrFSVPTP...RTPRTPR
  895-  934 (22.89/ 6.44)	TPRGGGtasgqgsvkydstdqgSP.ASTPSTsrpLNSVEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.95|      19|      23|    1424|    1442|       3
---------------------------------------------------------------------------
 1402- 1418 (21.76/ 8.86)	..PSARTTNLPVGSSSAPR
 1424- 1442 (30.01/16.13)	LAPSIKPANTTSSSGFSSG
 1449- 1467 (31.17/17.15)	LAAGANPTERSQGSSLSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.02|      23|      23|     285|     307|       4
---------------------------------------------------------------------------
  285-  307 (38.20/21.25)	RLPSLSHSSSSTSLPFASKHKIT
  309-  331 (39.81/22.48)	RQEKLDKNQKRSLLPFHYRPAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.45|      67|     526|     172|     251|       5
---------------------------------------------------------------------------
  172-  251 (101.02/79.72)	MFLTPPiSPEQivigDSGSIPSMV.............................SYSAAAPDGMGSVQGSKIseKIPSIFHKriiQRTWKEWIlnkSQSKRAP..MMKGGTL
  698-  795 (107.43/55.72)	MFPTPP.SLEQ....HPAFSPVMCykdgigsetlttlgmlespafsmttnqltEFKIEVEDGLGSPKPEEI..KDFSYVHK...TSTFQPFL...GSSAFAPlkMLPSQCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.11|      16|      18|     421|     438|       6
---------------------------------------------------------------------------
  392-  425 (17.91/10.05)	LPPTLSPQPRGQEaeslyppsipvtpilyhsGLE
  426-  442 (24.21/11.08)	LQPLLSTEGRTVH.................gGQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.50|      26|      26|     518|     543|       8
---------------------------------------------------------------------------
  495-  514 (24.80/10.13)	VNTP........FQS.TALKRllAQPNK.R
  518-  543 (48.10/27.11)	VEEPSSVPAMHYFDL.YPLNR..RRPGK.G
  544-  571 (34.59/17.27)	LRDVSDPYTFQDGDIkYSFTR..AKKGKlG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.43|      53|     526|    1348|    1401|       9
---------------------------------------------------------------------------
  582-  613 (39.59/11.85)	........................SDDGTGPKDISVAGHSTSMS.DGKDAM.SIFRSA
  642-  692 (60.11/21.16)	LHDLDnlFDNSDEDDNEAVSPShcSKVPLQGTEERSLAKDTRTAVPYPPTV.......
 1348- 1401 (90.73/38.72)	LATLQ..LDSSLLMPPKQTTPS..SQERTKPGRPMVPSHSTPFAVPGPPPVgSSFTST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.52|      26|      28|     962|     987|      11
---------------------------------------------------------------------------
  962-  987 (53.65/37.87)	S.NFDSC.CICACN..MNIK.GADVGLYIPD
  988- 1018 (33.87/20.84)	SsNEDQYrCTCGFSaiVNRKlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.77|      19|      27|    1706|    1725|      13
---------------------------------------------------------------------------
 1706- 1725 (30.53/25.33)	KIGLQKLWEWcTGIIQMSSL
 1736- 1754 (33.24/21.05)	RLGHGELKDW.SILLGESSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.73|      15|      26|    1165|    1185|      14
---------------------------------------------------------------------------
 1165- 1185 (18.82/22.44)	LSLQPFlqdaiQKkRTGRTWE
 1194- 1208 (29.91/15.50)	LTWQQF.....HK.MAGRGSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      10|      26|     379|     388|      15
---------------------------------------------------------------------------
  379-  388 (20.82/ 9.53)	LNPMDSPHSP
  408-  417 (20.23/ 9.01)	LYPPSIPVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.44|      14|      26|    1308|    1322|      16
---------------------------------------------------------------------------
 1308- 1322 (23.12/18.03)	KLTDEVVSDWFnAPW
 1334- 1347 (27.33/16.19)	KLYAQVCRHHL.APY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.77|      16|      32|    1101|    1117|      18
---------------------------------------------------------------------------
 1101- 1117 (24.73/16.64)	VRAESNDSWVECfNALE
 1136- 1151 (30.04/15.56)	VRSATIHSWPHS.NVLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      19|      31|    1650|    1670|      22
---------------------------------------------------------------------------
 1650- 1670 (26.82/28.09)	GEASQQCnVLFVgYCLSHDQR
 1681- 1699 (33.84/22.67)	GELLDTC.VINI.YLPNRSKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32288 with Med13 domain of Kingdom Metazoa
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