<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32265

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQTRGSGLPPRSQAPPRRPGKPVQSLVQPDCIDPALEDDRPSALQHAASEPARPAPRGRPPIFYTAMANYASDLALHAFPYQPIANLPLPPRPGSVHLREASQQRRIWPGGSGVKDAPKPGGPDVVAPPVHFPGGKAADVFPWTGSNAEDNLSEALVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPGTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFVDGVIGGIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCASERLFIWLLVVSISHYWIDVTCCRRRGKRLAESLLNQLDRIYRLEDVGPYMAVLQYLENTIVRLLAARPACLLLPTAWPQYSPLLHKLAERRNHIHITQAIRRLEQRNCRLLQSPQKSSSAAAQTPAGRVYRVLDSVDYTKPVRIEDLSFDCMEIIADAPRLIAVLLRWTCTYHREGAHRVYLATRLLRRWNHLGADVYDGIVSYLREMTWVATGEPSILFKVVAELVRSKTFATGRYLQWLIATGSVGQCADLSLPTSWPLRLVTEIPLTGLPDQICTLRSTLLRGTVHSAESEQRALAYAKHVISQALPALFGLYSSATKHDEMQLDKLSPTIKFELGIWLRRQVAQYAEVNQHVPTKDSSIEETAAVSLLTPLDFHVVRSYIERFGDLAILADIVGIATSSLDSSVLASSADTINYHAKAFRAIGAFDPLFARVAARHAALRTIRFPDRELLLSLASLARTAHTDGQLTQLLNYDLSQLSQRNSLVACSPASDNMGEVMQTGSSSDDEIERILSSGTSMDQQMMARVLRKIVSNLEEHSAKGPEQLNNHRGWFYRLRCFDEPTFDMVVNEWVISSLMAQRTDVLRVALPTLAGSGCLALASFLETLRICIAKLKSSPSEGGFQSTLKGMYLVLPSDALAQSCSPQDAYRYRLEQRRLCLETDGRFMQCMGELIGLGSMMSSQKIQTQLASLLRSRPVLSILNTHIATDPGCLSRLSKDASNDCLNEALGTLLDPNNHLRLSEKTPEQQVVAIFAIASELSLPICQAAIERIFSSRATASDGSSESLSATLLSAIRTAVEKDQPSGLELLASLDASLTDQIRHNAEREIINASAFLATSSAAKTEESEIVSPRTVQKFLAVIDLTSGSSTDTTEQSTMLQALIERLKGMAQALDENRLSVLDMYAWLNALLRLAVSHASPILSDATHPHQAAMMSAMAALLTHPSLELYPTITEHVFDVTVFLSDYISDDVRFHVIRLDGARLANDSRCVFILGVTAPVDGWLVLARPVNTPPNQPSSQPATPAPLSGQPPYQSSQASATGSATPQQRYASQQQQQQQQQQRHQQMQAAQQAQQMRNMQQYSQHPQNKMLPAQLQRTPSGQATPTPLTPMQQMQQMQQRAMQPSPVYSQRPAPVAGQGQGQAGAQVPGKLHLKQDKEIRHYPFVQPRWEILAESSGNPTGNETAINLSLFGARRV
Length1567
PositionKinase
OrganismSetosphaeria turcica (strain 28A) (Northern leaf blight fungus) (Exserohilum turcicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Exserohilum.
Aromaticity0.06
Grand average of hydropathy-0.253
Instability index54.61
Isoelectric point8.82
Molecular weight172866.36
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32265
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.95|      14|      18|    1380|    1394|       1
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 1380- 1392 (20.66/ 8.03)	.PVNTPPNQPSSQP
 1412- 1424 (17.19/ 6.62)	TGSATPQQRYASQ.
 1477- 1488 (24.09/ 7.55)	TPL.TPMQQM.QQM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.65|      13|      18|    1425|    1437|       2
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 1425- 1437 (23.69/10.83)	QQQQQQQQQRHQQ
 1443- 1455 (21.89/ 9.42)	QAQQMRNMQQYSQ
 1489- 1501 (20.08/ 8.01)	QQRAMQPSPVYSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.51|      24|      24|    1066|    1089|       3
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 1066- 1088 (35.11/22.16)	....RSRPVLS......ILNTHIAT..D.PGC...LSRL
 1089- 1113 (17.37/ 6.76)	S..........kdasndCLNEALGTllD.PNN...HLRL
 1114- 1144 (20.02/ 9.06)	SektPEQQVVA......IFAIASEL..SlPICqaaIERI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.14|      14|      29|      21|      34|       4
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   21-   34 (28.87/14.41)	PPRSQAPPRRPGKP
   53-   66 (24.27/10.77)	PSALQHAASEPARP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.66|      18|      19|     950|     967|       5
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  950-  967 (29.19/23.07)	MAQRTDVLRVALPTLAGS
  972-  989 (28.47/22.28)	LASFLETLRICIAKLKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.83|      21|      24|    1149|    1172|       6
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 1152- 1172 (33.30/25.49)	SDGSS.....ESLSATLLSAIRTAVE
 1173- 1198 (30.53/14.07)	KDQPSglellASLDASLTDQIRHNAE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.18|      24|      54|     576|     599|       7
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  576-  599 (40.91/23.73)	LREMTW.VA.TGEPSILFKVVAELVR
  607-  626 (24.60/11.34)	.RYLQWlIA.TG..SV..GQCADLSL
  632-  656 (34.67/18.99)	LRLVTE.IPlTGLPDQICTLRSTLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.92|      18|      25|     103|     123|       8
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  103-  123 (30.92/24.01)	PRPGSVHLREASQQrriWPGG
  130-  147 (37.00/20.54)	PKPGGPDVVAPPVH...FPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.12|      11|      25|     357|     373|       9
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  357-  373 (14.45/23.61)	HFldWIvnglD.TCASER
  385-  396 (22.68/12.40)	HY..WI....DvTCCRRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.81|      11|      18|     790|     801|      10
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  790-  801 (16.49/16.28)	HAkAFRAIGAFD
  811-  821 (21.32/14.99)	HA.ALRTIRFPD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.88|       9|     203|     550|     572|      12
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  536-  548 ( 9.43/10.10)	LLRWTctyHrEGA
  558-  566 (19.45/15.16)	LRRWN...H.LGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.08|      13|      26|    1207|    1219|      13
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 1207- 1219 (22.34/15.03)	FLAT......SSAAKTEES
 1230- 1248 (16.74/ 9.21)	FLAVidltsgSSTDTTEQS
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.15|      26|      55|     177|     204|      14
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  170-  196 (38.48/17.98)	KAGVSN.........................kPQIMNESNTARPSLINNLKN
  197-  248 (30.67/15.84)	KSGLSTlstlfvavlekrqqtgrlqtpntfkpPPRLTLRDSTREQWLHDLAN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32265 with Med12 domain of Kingdom Fungi
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