<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32264

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDGASYNMDVDDLFGDSEHVNIQSINTTPPVKGLDARIDELGSSGCCQKISWSKNGCVAYISPDGYSVNLNIFSRHPETGKWDLRRNVPLDLPQGRDVFPLTHLSWSHLGNDLAVTDEAGRVMVFSCAMALDRMHFTRAEIAHPESEADAVVGMHWLAILPYAQKNLIAWSAAREGNKWKWNIRQHLFNNAHHPVDGKASLIYLKRYGELKLRFQQNDNNWQEVSAQLGPMVATREAFTHAAFASNNDNNLLLAAYDVKRRLHLYRVEAIWNVPADKRSQNAGPFEKPTIHVSLLALEDACNPVDMINDDLSNGTSSKGPAAAAQLTHLNFLPVTPQQDDGSVPTIQAIFSKPPNPISYDMNPQETRYSTIVKWEVHQEQQNQLHPGLDHVTSKKKSVGSIPAQTTYLLKRQPDFSLHAVVLEFYPIWYNMLLAFCYSDGSIEFRKRSTMEIIMPDDNTEHVTSLLQAGFIFQHAEPSLHVAFSPNHCMAVGLQLDGTVKLRSMEYSHGTLSTDDEDPRHSAALAALILQSSSAANQYFSSDDIFAIVGSMSDKRKHDFINLLFEGLQVNIDCGIDDSSTNHFILLGRSPFFVKSLSAMHLLGLHGNIDRTLSSKIAWQILNIKYVTQILTTIVRMHGDVGKTNLRPEAVPQMIGTIRWTMHFMAYTLDELFSLGRALSDIPAAELTREVLENKIREMNKPAVLILLSAFPRAMMKLWAQPIQWVKRSAEAHANNPNAPIQSPESKKLYTPLLSAVTELPFEWRWFEVLISETLNHVRGIYKQRNLNDAQRNLVEREILLGRVPDILFPVAKRLVTDTLWNSNQQNGCLADKLDMGKLMFFDTTWLGFHASRRAQIWHDSHVVDVCQKMIIRGVGTWVHPVSTGPGQHMGSRNRSDSIQSTGGAHPDANGERKRKNMLRQCVRCGACMEDVVPGLLGYTIHHYQWLVGVSKHCVCGNSWMLAETKPTAK
Length969
PositionTail
OrganismSetosphaeria turcica (strain 28A) (Northern leaf blight fungus) (Exserohilum turcicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Exserohilum.
Aromaticity0.08
Grand average of hydropathy-0.283
Instability index44.80
Isoelectric point6.73
Molecular weight108890.89
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32264
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.29|      18|     101|      69|      86|       1
---------------------------------------------------------------------------
   69-   86 (35.53/18.78)	NLNIFS..RHPETGKWDLRR
  166-  185 (28.76/13.93)	NLIAWSaaREGNKWKWNIRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.52|      30|     101|     256|     292|       2
---------------------------------------------------------------------------
  256-  290 (47.56/43.29)	YDVKRRLHLYRVEAIWNVPADKRSQNagpfeKPTI
  359-  388 (53.96/34.63)	YDMNPQETRYSTIVKWEVHQEQQNQL.....HPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.87|      31|      36|     540|     575|       3
---------------------------------------------------------------------------
  540-  572 (49.46/49.83)	SSDDIFAIVG.SMSDKRKHDFINLLfeGLQVNID
  578-  609 (51.41/32.88)	SSTNHFILLGrSPFFVKSLSAMHLL..GLHGNID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.68|      55|     105|     647|     701|       4
---------------------------------------------------------------------------
  616-  645 (28.20/13.59)	............IAWQILNIKYVTQILTTI..VRMHGDVGKTNL...............
  647-  701 (92.19/61.18)	P..EAVPQMIGTIRWTMHFMAYTLDELFSL..GRALSDIPAAELTREVLENKIREMNKP
  751-  809 (81.30/53.08)	PllSAVTELPFEWRWFEVLISETLNHVRGIykQRNLNDAQRNLVEREILLGRVPDILFP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32264 with Med16 domain of Kingdom Fungi
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