<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32261

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESMIKEWSVFLDRCLEARIHSDVFAAAVAQLHAKSPLPGRKVAALLLRPRVAGAGIIDPRLIGFLEQLLALNKVDASDVLTITFLYSKDRLPVKTGDDKHAKDAPWSNPPELEEIVFHRLHKAFAAEERPINNVEGLRTLVVITRWMQAMVTSHTSDTMIQAMAGIQQPQQQSINVREGLAMLVIGVIENSKILRILNHEKAKDVRKAFTQSLSSFIPFLSNNSSGSQTSLSLANRLEISQKHHDFYPKLSHVNGEGNEHAGLEVAALQLDAVMELPQANTRAGMYIFLNALLVARPLTDDFTIISHLHTRYKLEPQNMATDLITAAFDILANAMYRSEPTETLFYLKSFLINKVPVLLTQISGSIFPMTVEMCITQALNHVDPSAFPSFSQGFDDIMGSNNSLSDVRQDYLNACVLHGLIPGGTVERLLGEAPMQGPPAKRYERKELLNQCKSNFDKVSLYIDELENLDGNAGAIVAAVTDFISHLCETQTTMYLKQLSCLIFKKPRAMDVMLQFTSPASILRPLCQFLDDWHYDSDQGEYQPVYDEFGAIIVLIMAFIYRYDLTYHDIGIGHDAFIAKLLQHGHESIRLNEMTEEQSRHLGSWLKGLYDSDKEGLSNDVFASCRPQEFYLIVPTLFKQTVIACSTGVLSFETVKGGLEYLGETFLLPSLIGGLTWMASYALLQTHNDLDAMIRIFNEVILSTPSSGDAQAMHSTIIAMVSSHLEKCFRTLQRREPNRTTLEPFIQAIKVHAHYERTVYASMKELDQWTNAPNSTLNTSLRHTVSQLSQWASTASMQPNPPSYTHRQVYASLKMLGAMRTLRAIVDEVKAQTETGNRAAALDVGVSMICAPTVEDSPISVDWVGSSIPAPTPQRTHINLREILKQAFDSAANLVTADPLTAETIVRLHRRVEAHFASLAENGLQAPAINMPSVNIADMQSQSISDHLNRAMDDAAAASMVDDISNMDNKALQRSMDELTGTEGLDLSGIGMGNGDGGTGDMSTDLGNLPDLDLGDMGGMGIDMDMSMDMGGGGGDDDWGLDFDNM
Length1047
PositionTail
OrganismSetosphaeria turcica (strain 28A) (Northern leaf blight fungus) (Exserohilum turcicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Exserohilum.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index40.83
Isoelectric point5.18
Molecular weight115642.57
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      12|      15|     658|     669|       1
---------------------------------------------------------------------------
  658-  669 (21.63/13.14)	GGLEYLGETFLL
  674-  685 (22.98/14.42)	GGLTWMASYALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.48|      15|      17|     845|     860|       2
---------------------------------------------------------------------------
  845-  860 (24.98/23.29)	VGvSMICAPTVEDSPI
  865-  879 (29.49/21.84)	VG.SSIPAPTPQRTHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.20|      15|      16|     547|     561|       3
---------------------------------------------------------------------------
  547-  561 (26.86/18.26)	YD.EFGAIIVLIMAFI
  564-  579 (25.34/16.80)	YDlTYHDIGIGHDAFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.37|      28|      36|     982|    1010|       4
---------------------------------------------------------------------------
  982- 1010 (46.54/27.07)	GTEGLDLS.GIGMGNGdGGTGDMSTDLGNL
 1019- 1047 (51.84/26.19)	GGMGIDMDmSMDMGGG.GGDDDWGLDFDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.19|      32|      36|     210|     242|       6
---------------------------------------------------------------------------
  210-  242 (48.26/34.64)	FTQSLSsFIPFLSNNSSGSQ.TSLSLANRLEISQ
  247-  279 (50.93/32.03)	FYPKLS.HVNGEGNEHAGLEvAALQLDAVMELPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.71|      10|      48|     758|     767|       7
---------------------------------------------------------------------------
  758-  767 (18.87/12.76)	RTVYASMKEL
  808-  817 (18.84/12.72)	RQVYASLKML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.89|      21|      40|     123|     143|       8
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  123-  143 (36.05/23.37)	KAFAAEERP....INNVEGLRTLVV
  162-  186 (31.84/19.85)	QAMAGIQQPqqqsINVREGLAMLVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.69|      10|      17|     360|     369|       9
---------------------------------------------------------------------------
  360-  369 (18.14/10.92)	LTQISGSIFP
  380-  389 (19.55/12.37)	LNHVDPSAFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.08|      11|      16|     423|     433|      11
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  423-  433 (19.84/12.51)	PGGTVER..LLGE
  440-  452 (15.24/ 7.94)	PAKRYERkeLLNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.91|      37|      39|     887|     923|      14
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  887-  907 (23.00/10.44)	...................QAFDSAANL..VTADPLTAETIV
  908-  946 (47.01/29.27)	RLHRRV.EAHFASLAENglQA..PAINMpsVNIADMQSQSIS
  948-  981 (34.89/19.77)	HLNRAMdDAAAASMVDDisN.MDNKALQ..RSMDELT.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32261 with Med5 domain of Kingdom Fungi
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