<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32258

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGILMMNHTASHAATASRDGATMKRSHDGNFTNGDPGDAPRGSPAGGSMAHRAPPKDAPLHAASASSTSLEHYSELPPEIAHIGPEQYNALSTLLLRISQESYNDLSAILQKMAALPIAPVANGALPNGLGAANMQGNAEANKRKKLLLLQFAQEQRSKFIKLLVLAEWGKKAAFDISKLIDLFSWAGAQARHMDAADDQLDRIKLLSNIARENNPDIATALQVLSTGKASWMPSLGYIPPAPISSEQALKLLRYMNTSLSIRLNVHENLPRHLRNWRIHSGRVTFVIDNELEFDVMSFVEDASEQWFLIDLRLLFTPAPTVTIGSRFFMQLKQQADFVLKDKGLSGLYDFLNNFILTHKISVLRSQAAALVRSGWAGSLKVEPVHRLLVVQYWINKPGKKNWIEIGISTNKPKNAKISWRGPPRPSLTTRWFRQGKEVKDANFAFDWTNLSMEKVIKLVIARHTSDILQATKESFRSGLAAEADLSEAEPADCKLNASLGTKSTLITLSLEPVTGNHIVRPASALSARAENAFNMGREPTQMAHVMTQVLAGTLLSLIQRNAQQLGWQPVARQALNPQIVKAAVKLDVISSALYWPRGWSQSWAFAAVIDSSGESWWILEIGPSGNSIEYAEQIRMDRPDGSTLPINRNTLASLERVALQLLCFRVTARQLEKEKKMYALEEELGQTSASSGARRIARRWVLRVQTADLLTTRSKHGSWLESEIKITCEGLRASGQNVWHMATGRMVKSVAADMHKLMAASPQNAFKFADDGNFRILLSTPFGHDILGELRARLRDVNRLRSFATTLQKRKMRLASSSLQRVQFLYGPSPYSAAVSFSSEKEVSIELSSKNPHHRILNLLNDIANDRLPSFITLEPSDSNGLDRFCTTLVLTRPLFKVIREIEQRSPGNVRNPAIHVHSILKYRLTYENPVCTFDIRLQPKDDEVFWFVEDNLRPKDPNVLPTPERAPGHRRLDILQGKLKGLFSSKGPGWFGTRNGMVAGLDAIPDALRKLDECVLSCKMEGGYVPPPLERPTQQTQNSGQGLAQPNGMHQGNQQQQQQQQQQQQQQQQQQQQQQQQQARMQQQARHQQAQQMRKQQANPQLNVRAQQPNGRPLQQHMMNGRQHMQQQQGRGGRPGQTQNNVIEID
Length1149
PositionTail
OrganismSetosphaeria turcica (strain 28A) (Northern leaf blight fungus) (Exserohilum turcicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Exserohilum.
Aromaticity0.06
Grand average of hydropathy-0.450
Instability index51.61
Isoelectric point9.75
Molecular weight128329.93
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32258
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     100.44|      13|      15|    1053|    1065|       1
---------------------------------------------------------------------------
 1053- 1065 (28.45/13.95)	HQGNQQQQQQQQQ
 1069- 1081 (26.37/12.40)	QQQQQQQQQQQQQ
 1090- 1102 (21.08/ 8.46)	HQQAQQMRKQQAN
 1120- 1132 (24.54/11.03)	HMMNGRQHMQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.50|      13|      16|     163|     175|       2
---------------------------------------------------------------------------
  163-  175 (22.36/13.59)	KLLVLAEWGKKAA
  180-  192 (23.15/14.35)	KLIDLFSWAGAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.55|      11|      16|     338|     349|       3
---------------------------------------------------------------------------
  338-  349 (14.39/14.32)	DFVLKDKgLSGL
  355-  365 (19.16/12.41)	NFILTHK.ISVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.94|      29|      60|     452|     480|       4
---------------------------------------------------------------------------
  452-  480 (45.60/29.23)	LSMEKVIKLVIARHTSDILQATKESFRSG
  481-  505 (30.61/17.12)	LAAE..ADLSEAEPADCKLNASLGT.KS.
  510-  538 (44.72/28.52)	LSLEPVTGNHIVRPASALSARAENAFNMG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.88|      43|      43|     949|     991|       5
---------------------------------------------------------------------------
  873-  932 (37.51/18.33)	.F............I..TLEPSDSNgldrfcttlVL.........TRPlfkvireieQRSPGNVRnpaihvHSILKYRL....TYENP
  949-  991 (81.40/48.73)	WF............VEDNLRPKDPN.........VL.........PTP.........ERAPGHRR......LDILQGKLKGLFSSKGP
  993- 1051 (48.98/26.27)	WFgtrngmvagldaIPDALRKLDEC.........VLsckmeggyvPPP.........LERPTQQ..........TQNSGQGLAQPNG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.11|      25|      43|     205|     233|       7
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  205-  233 (36.78/36.98)	IKLLsniaRENNPDIATALQV...LSTGKASW
  251-  278 (39.33/27.99)	LKLL....RYMNTSLSIRLNVhenLPRHLRNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.15|      22|      47|     658|     688|       9
---------------------------------------------------------------------------
  658-  679 (37.09/35.01)	RV.ALQLLCFRVT.ARQLEKEKKM
  705-  728 (28.06/ 9.18)	RVqTADLLTTRSKhGSWLESEIKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.97|      64|     741|      24|     128|      11
---------------------------------------------------------------------------
   24-   91 (107.01/79.57)	MKRSHDGNFTNgdPGDAPRGSPAGGSMahRAPPKDAP.LH..AASASSTSLEHYSELPPEIAHI.GPEQYNA
  768-  835 (95.96/38.51)	FKFADDGNFRI..LLSTPFGHDILGEL..RARLRDVNrLRsfATTLQKRKMRLASSSLQRVQFLyGPSPYSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.57|      58|     222|     367|     429|      12
---------------------------------------------------------------------------
  367-  429 (94.47/69.36)	SQAAALVRsGWAGSLKVEPVHRLLVVQYWINKPGKK.NWIEIG..ISTNKPKNAKIswrgP.PRPSL
  592-  653 (95.10/55.73)	SSALYWPR.GWSQSWAFAAVIDSSGESWWILEIGPSgNSIEYAeqIRMDRPDGSTL....PiNRNTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.12|      27|     448|     107|     134|      13
---------------------------------------------------------------------------
  107-  134 (43.62/33.19)	LSAIlQKMA.ALPIAPVANGAL.PNGLGAA
  557-  585 (40.51/25.60)	LSLI.QRNAqQLGWQPVARQALnPQIVKAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32258 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EGGYVPPPLERPTQQTQNSGQGLAQPNGMHQGNQQQQQQQQQQQQQQQQQQQQQQQQQARMQQQARHQQAQQMRKQQANPQLNVRAQQPNGRPLQQHMMNGRQHMQQQQGRGGRPGQTQNNVIEID
2) MPGILMMNHTASHAATASRDGATMKRSHDGNFTNGDPGDAPRGSPAGGSMAHRAPPKDAPLHAASASSTS
1024
1
1149
70










Molecular Recognition Features






MoRF SequenceStartStop




NANANA