<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32256

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCSTNAQAIGDFEAIAYQAISVTRTTTTTTTTTSASSKARPWPASEDVRAAEAELRHALHLVAHDASRPWLWLFKPTTVDKIGQTSIQLPDLDGYRLQREHTGAIKAIDLVRPPMRPGTPHTTAASNQPPSTNAPQRGPQGVAPRQAQGNTQAQTSADPPQPPDCFTLYELFTSAVIALVSFQVVKNCDVVALNYRTFVSKATKQIGDAQADADSQPELQRLTSIHAHWTSSGTLLLSTFTDKNHLIRCLSSVSTQLEERQLTGRCIRVAPNGLLATITSFEDPLDSVAEETGVRHRKRTKVTTLEQNIEKWKTSVRRWLSWKGYALPDLEKRSSWVRIRTTLIPTSTVSSPASVAPERDVLWPRALCFFHVTEEPDAIAAGINVSDSNVVRWFETPESTGFKDPLDVAQEWFLGKPDRDKILEARRKAKKAEEDAARRKEEHPSLHPSSPLNARTGAYGDLQAVGGVYPTPPDGIAPGTGVSYSDTPSVSGTASNVILAPGGNNPAINLSAPPQNTKADDQQMITTSPAVPSAADNFNTSSGNDDLFEDMDEDGYGGDRINDTDFDFFDGPDNDDVDMLDAPALPEQNAPPVDVIQDHASGAVTESHPQDEMSDPFAALENALATASEPPMAHDDVKGKDRADMRAPKIEDTGFSDSKKLSPTRRNVSFSKAPTPPLSPSKILKALEPSPTKRSASRTRAEGAVDGYRDAQFDPVAFNRKMSLSDAKYQGGRFSAHRPRTGDRQREPSPTPTLGTIACQPKFSRDFPLLSKLRLAAGIASANRIPEIASLARAASVDSDSSSETSDVFDEDSGDEEAEAMPAVVTTNIIMPAKRKLQSEGNATPLSVTSFADSLGGDWMELYGLHLDEACLNTFEPSLWDWSLVNVPGPAERLVAGARYSLPALLPSPAQMPDTPTSQPDPTYEVPDEKPLSGKECISITQIVTDQIVSTTLDMLGEDSPIRSEPTMDPVAEKPWNSVIKEIFPTAADCDLPTLVGVHEVFQDYAALAKAQQRPPARKNDGPAITGSHMYQIQAPFLRVRRAETHWDLLPPAVAFWEPLGLSPISTQKNIVAFCVYPHSDAIRPCLENFLLNLQLAYDGCKLGSHSRVETVVEFEGGLVPVKATSAITPRDSFKLLKETCIQLGKLLALQHSKIREQQQDSKVDAFVIYMIDPFGGPSAVWELCSAFWALFQAYTQVHPGRTDQPQKPDVVLQIIPIKYISSFDTPVVLDPSTYFSLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEEILPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGTWVTAAWTDSCGKSQAVVSYHLGTRMFREIAKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAVDADPPYQFTPTVSTQNTATGAGATTPVSTPQAGVSPSDPGPGLTPAATPAADPTATDPTADPEARLVDVTDDTWGIILAHRLHNSYSSTQFSPALISGLLVKRGETIQTSNSTAHPIPDPEQGPIVVAVNFLWIGAVGSSRNATNSPFPPTSSSATPSSSSSDLPSPGGSNLPNPYASNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRNGTVPWHVAAAKRGVEGLGKIGGGGINGTIA
Length1666
PositionKinase
OrganismSetosphaeria turcica (strain 28A) (Northern leaf blight fungus) (Exserohilum turcicum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Exserohilum.
Aromaticity0.07
Grand average of hydropathy-0.369
Instability index45.58
Isoelectric point5.30
Molecular weight180353.28
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32256
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.43|      25|      26|     654|     678|       1
---------------------------------------------------------------------------
  654-  678 (42.77/28.33)	KIEDTGFSDSKKL.....SPT..RRNVSFSKA
  680-  706 (25.42/13.16)	...TPPLSPSKILkalepSPT..KRSASRTRA
  708-  732 (33.24/20.00)	GAVD.GYRDA.QF.....DPVafNRKMSLSDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.44|      18|      22|    1417|    1436|       2
---------------------------------------------------------------------------
  471-  485 (27.57/10.12)	GGVY.P..TPPDGI.....APGT
 1419- 1438 (30.08/16.06)	GATT.PvsTPQAGV..SPSDPGP
 1565- 1585 (24.79/ 8.23)	GGSNlP..NPYASNpgTPQSPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.54|      23|      26|    1615|    1639|       3
---------------------------------------------------------------------------
 1615- 1639 (34.00/28.26)	VLGQFRALGLLAKLRGmrGTRNGTV
 1643- 1665 (38.54/24.38)	VAAAKRGVEGLGKIGG..GGINGTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.77|      19|      26|     511|     529|       4
---------------------------------------------------------------------------
  511-  529 (34.38/20.10)	PAINLSAPPQNTKA..DD..QQM
  534-  556 (24.00/11.39)	PAVPSAADNFNTSSgnDDlfEDM
  569-  584 (29.38/15.91)	TDFDFFDGPDN.....DD..VDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.78|      27|      28|     971|     998|       5
---------------------------------------------------------------------------
   71-   95 (25.14/10.09)	......ASRPWLWLFK...PTTVDkigqtsIQLP
  757-  773 (26.15/10.81)	PTLGTIACQPKFS..RD.FP..............
  971-  998 (49.49/31.57)	PTMDPVAEKPWNSVIKEiFPTAAD......CDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.29|       9|      28|    1508|    1517|       6
---------------------------------------------------------------------------
 1508- 1517 (14.94/10.66)	NSTAHPIPdP
 1539- 1547 (19.34/ 8.83)	NATNSPFP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.54|      21|      27|     125|     145|       7
---------------------------------------------------------------------------
  125-  145 (38.29/18.29)	PHTTAASNQPPSTNAPQRGPQ
  149-  169 (38.25/18.26)	PRQAQGNTQAQTSADPPQPPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.06|      10|      26|     822|     831|       9
---------------------------------------------------------------------------
  822-  831 (17.34/ 9.93)	EAEAMPAVVT
  845-  854 (17.72/10.34)	EGNATPLSVT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32256 with Med13 domain of Kingdom Fungi
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