<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32237

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALFGRAAEESFLSLKELVEKFKTTELSDTDKKVSLLKYLVNTQQRVLRLNALAKWCKQVPLINYFQDLGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPKCLDDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEISEVKISKGTVTLSVDGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGLIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPANQEGEADSVSLRTPGVKLMYWSDSDKISGPFIKIEPGPDFQIKCSHSTFVIDPFTAKEAKFSLNQSCIDVEKLLLKAISCNRYTRLLEIQKELLRNARIAQAPGDVILQALLDEPATEGGTMVDFKEQVEPEVLRVRAYGSSYFTLGINIRTGRLLLQSSKSILTPSILEEFEDALNQGSISAVDAFINMRSKSILHFFAAIGKFLGLEVYEHGFGISKVPKSVLDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLVETQMDGAGQPQSFNDPSNILRVKKIDIGQIRILEDDLNLITSDVVRFVSSFSDTESINQASGQRHPGLVDEASAEMSGSQLSFSSIIDEVFGLQKGTSSLVSSDGHGSVPKNFSVVNGHGKDPMLTSYHSDSLYNLQGPLQSGSFNMLSSPHGKGSAMKKIAISNSEQELSVIQSPSLSAGNGVYESGSRLVTESTSSPLPVCQKSRKRSASDLLRLIPSLQGMQGVASPNKRIKTAGLVQRELVKSWIPASQTLSTAVTTSTKTIGCSYWNLIAEANKGNAPSTVFVYALLHVVRHSSLSIKHAKLTSQMDALDIQYVEEMGLRDAFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKTTPWGAEVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGIKPDEKTEECTVIPAIKGPAGGKGTGEPVDRWRAFKIEAVGLTSLWFSFGSGVLARFVVEWESGKDGCTMHVSPDQLWPHTKFLEDFINGAEVESLLDCIRLTAGPLHALAAATRPARASTATGMPVVPTTASSRQSNQLQQTPSNLAAPNAVGQSASTTSGNTVASSAASPLGGTFHGVAMLAAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGTVNPNSANPTVNGGNRINFSPSSAMSRAAMNRVASVASGSLVVGAGLPMRRTPGTAVPAHVRGDLNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQQQQNGSSAAAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQSQQAGEIAPAQRPRIELCLENHSGTDLDNNCAAKSNIHYDRPHNMVDFALTVVLDPALIPHINAAGGAAWLPYCVSVRLRYTFGENPSLTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSATGDLTQGKLKLIADSVQRTLHLCLQGLRDGNNNNTL
Length1680
PositionTail
OrganismCapsella rubella
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Capsella.
Aromaticity0.07
Grand average of hydropathy-0.111
Instability index43.37
Isoelectric point6.88
Molecular weight183485.50
Publications
PubMed=23749190

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32237
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     403.04|      96|     591|     641|     736|       1
---------------------------------------------------------------------------
  641-  736 (166.30/108.86)	DEVFGLQKGTSSL.VSSDGHGSVP.KNF.SVVNGH......GK.DP..MLTSYHS...DSLYNLQGPLQSGSFNMLSSPHGKGSAMKK.IAISNSEQ..ELSV...IQSPSLSAGNG
  922- 1021 (104.85/65.32)	.DLWELQKGSKTTpWGAEVHIA....NS.SDVDSH......IRyDPegVVLSYQSveaDSIKKLVADIQR.....LSNARMFSLGMRKlLGIKPDEKteECTVipaIKGPAGGKGTG
 1227- 1322 (131.90/84.49)	DQVW.LQPATPPK.GGASIGGSLPcPQFrPFIMEHvaqelnGL.EP..NLTGSQG...TVNPNSANPTVNGGNRINFSP...SSAMSR.AAMN......RVAS...VASGSLVVGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.88|      51|     286|     178|     232|       2
---------------------------------------------------------------------------
  178-  232 (79.03/74.12)	SKGTVTLSVDGEFKVLVTLG....YRGHLSMW..RILHLDLLVGERSGlikLEVTRrHILG
  454-  510 (78.85/59.83)	SKSILTPSILEEFEDALNQGsisaVDAFINMRskSILHFFAAIGKFLG...LEVYE.HGFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.58|      17|     258|    1323|    1356|       4
---------------------------------------------------------------------------
 1339- 1356 (28.28/45.99)	GDlNTAIIGLGDDGGYGG
 1601- 1617 (33.30/10.43)	GE.NPSLTFLGMEGSHGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.93|      24|     285|     577|     620|       5
---------------------------------------------------------------------------
  266-  289 (43.29/19.60)	IRQVRAL...LQGRWKDAIRF.DLISDT
  580-  607 (31.64/56.47)	IGQIRILeddLNLITSDVVRFvSSFSDT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32237 with Med14 domain of Kingdom Viridiplantae
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