<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32230

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALFGRAAEESFLSLKELVEKFKTTELSDTDKKVSLLKYLVNTQQRVLRLNALAKWCKQVPLINYFQDLGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPKCLDDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEISEVKISKGTVTLSVDGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGLIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPANQEGEADSVSLRTPGVKLMYWSDSDKISGPFIKIEPGPDFQIKCSHSTFVIDPFTAKEAKFSLNQSCIDVEKLLLKAISCNRYTRLLEIQKELLRNARIAQAPGDVILQALLDEPATEGGTMVDFKEQVEPEVLRVRAYGSSYFTLGINIRTGRLLLQSSKSILTPSILEEFEDALNQGSISAVDAFINMRSKSILHFFAAIGKFLGLEVYEHGFGISKVPKSVLDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLVETQMDGAGQPQSFNDPSNILRVKKIDIGQIRILEDDLNLITSDVVRFVSSFSDTESINQASGQRHPGLVDEASAEMSGSQLSFSSIIDEVFGLQKGTSSLVSSDGHGSVPKNFSVVNGHGKDPMLTSYHSDSLYNLQGPLQSGSFNMLSSPHGKGSAMKKIAISNSEQELSVIQSPSLSAGNGVYESGSRLVTESTSSPLPVSQTTDLSTLSDCPLLKKGQKSRKRSASDLLRLIPSLQGMQGVASPNKRIKTAGLVQRELVKSWIPASQTLSTAVTTSTKTIGCSYWNLIAEANKGNAPSTVFVYALLHVVRHSSLSIKHAKLTSQMDALDIQYVEEMGLRDAFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKTTPWGAEVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGIKPDEKTEECTVIPAIKGPAGGKGTGEPVDRWRAFKIEAVGLTSLWFSFGSGVLARFVVEWESGKDGCTMHVSPDQLWPHTKFLEDFINGAEVESLLDCIRLTAGPLHALAAATRPARASTATGMPVVPTTASSRQSNQLQQTPSNLAAPNAVGQSASTTSGNTVASSAASPLGGTFHGVAMLAAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGTVNPNSANPTVNGGNRINFSPSSAMSRAAMNRVASVASGSLVVGAGLPMRRTPGTAVPAHVRGDLNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQQQQNGSSAAAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQSQQAGEIAPAQRPRIELCLENHSGTDLDNNCAAKSNIHYDRPHNMVDFALTVVLDPALIPHINAAGGAAWLPYCVSVRLRYTFGENPSLTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSATGDLTQGKLKLIADSVQRTLHLCLQGLRDGNNNNTL
Length1697
PositionTail
OrganismCapsella rubella
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Capsella.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index43.21
Isoelectric point6.88
Molecular weight185271.48
Publications
PubMed=23749190

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32230
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.58|      49|     586|      82|     130|       1
---------------------------------------------------------------------------
   82-  130 (85.78/57.11)	STLSAH..DICFTQ.AADSLFFMHEGLQQARAPVYDVP....SAVE.ILLTGSYQRL
  667-  723 (66.79/42.67)	SVVNGHgkDPMLTSyHSDSLYNLQGPLQSGSFNMLSSPhgkgSAMKkIAISNSEQEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     500.91|     118|     260|    1008|    1127|       2
---------------------------------------------------------------------------
 1008- 1127 (199.75/105.43)	RKLLGIKPDEKTEECTVIPAIKGPAGGKGTGEPVDRWRAFKIEAVGL..TSLWFSFGSGVL.....ARFVVEWESGKD.GCTMHVSPDQLW..P.HTKflEDFINGAEVESLLDCIRLTAG..PLHALAAATR
 1162- 1278 (147.67/72.67)	PNAVG.QSASTTSGNTVASSAASPLGGTFHGVAMLAAAAGR.SGPGIvpSSLLPIDVSVVLrgpywIRIIYRKRFAVDmRC...FAGDQVWlqP.AT....PPKGGASIGGSLPCPQFRPF..IMEHVA....
 1280- 1386 (153.49/75.81)	.ELNGLEPNLTGSQGTVNPNSANPTVNGGNRINFSPSSAMSRAAMNR..VA...SVASGSL........VV....GA..GLPMRRTPGTAV..PaHVR..GD.LNTA.IIGLGDDGGYGGGwvPLVALKKVLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.24|      54|      59|     405|     463|       3
---------------------------------------------------------------------------
  405-  460 (88.13/68.41)	LldEPATEGGTM..VD.FKEQVEPEVLRVRAY.........................GSSYFTLGI.NIRTGRLLLQSSKSILTP
  466-  548 (67.11/38.62)	F..EDALNQGSIsaVDaFINMRSKSILHFFAAigkflglevyehgfgiskvpksvldGSSILTLGFpDCESSHLLLMELEKDFTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.76|      15|     173|     810|     828|       8
---------------------------------------------------------------------------
  782-  796 (23.35/ 6.97)	SDLLR.LIPSLQGMQ.G
  812-  828 (17.41/13.83)	RELVKsWIPASQTLStA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32230 with Med14 domain of Kingdom Viridiplantae
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