<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32173

Description "Uncharacterized protein, isoform A"
SequenceMECEQPEVVGGSAPLCRICITTHQQQNNTTTAATANLPMIPIFGEDALWQKITTLANVKISKNDTLPQQVCVGCAKTAISACVFKKKCEEADSFYRQQLRLQKIEGADPLEANAAADQAKSSGCSSGSGSSSGSGSSSTSSSSSSDDEDEDNEQEQDNDNDVVADEEQKRLQNGHGQTINGHRGNEADEIHDEIDDHHEPGRNAGGGEDLLRNGMELREANHEDDNDVEEINHLNQHHSDDGEITGHAGHPKEPFDFNSIRLMQEYMQHQMNKFPNGSATGPPGQDLELDLDQQHHDGDDDEDEEMSLPLIPEIELITPGDEALGDPSNPNDLVNGAGVGVVQGLQDPGFQCPHCYQIFEMKQILKAHMQSVHGAPGPVYECSNCRKTYFYKRFLEKHIRRGRCVKKRRNQTRPMQCSDCHVLFPTGHHLGWHKRTGCPSKAAKMPLQQLFKQNIVQFNNFPKRVAAGGARKPTAPDLHINNRKLGLANKRKGRTRIKLDAKKIALAKQLILREATTTVIANELNISRTFAWRLRKSLVNGVSLHERVVDPSQEEQHLQQLQQQHHHQQIQLQHHQQDDQQQAAAAAAAQAEREREHHHLSLPYSHLGLGLIKEERQDSEDEEHQHQQQQQHHHPSHHQLGLVDECGADEIGAEETAGYMGDEDAVCGLLHNGYDPDPDSDHIDHDPFEGTENNEHHSNGGRPGSVSPAPPLQPPTLGNSGMPVPVQVHAAARPDVEAYKRLLAESQHFPHIVNAQQLQMQQQQREREREQRDRGREQLQQQKAHNGGMPMLTRYPPSVMHALPVNLSLRSMPHMNSNESNGSSSSNTAAPVPVPGSSAASATVTPTGKKPRKPNVFIDDEKYAMAKLLVAQNSSTMEIARALNVSQMTAWKVRDAILKGVPLSYRNKRSDGRHSDEFSVKEQQQQQQQQQQHQQQQEQQQRQQEMQRQQQQQMEQMERLKQQRQQQELLLQQQQQQQQQQQQQQQQLRHHTPADTSHYQQQQQQQTTPKLLHPRRRLKAAERELRDKEITREILELIKEDSNIQYWKVSARLAEKGINISPSSVCQKLKSMGIHRRWKPGDKPPMLAISQLKAATVAAAAAAAGLAGVGGVVGGSAGLGGSSFGLADDSFEQQQFDMGGPHFLSAFTR
Length1149
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.951
Instability index61.80
Isoelectric point6.09
Molecular weight128325.74
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867
PubMed=26109357
PubMed=26109356
PubMed=25589440

Function

Annotated function 
GO - Cellular Component
PML body	GO:0016605	IBA:GO_Central

GO - Biological Function
histone binding	GO:0042393	IBA:GO_Central
transcription corepressor activity	GO:0003714	IBA:GO_Central
transcription factor binding	GO:0008134	IBA:GO_Central
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
negative regulation of transcription, DNA-templated	GO:0045892	IBA:GO_Central
nucleosome assembly	GO:0006334	IBA:GO_Central
regulation of apoptotic process	GO:0042981	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32173
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     188.07|      20|      20|     923|     942|       1
---------------------------------------------------------------------------
  554-  573 (32.63/10.39)	EEQHLQQLQ..QQH.H..........HQQ....IQLQ
  615-  630 (24.96/ 6.26)	ERQDSEDEE..H...............QH....QQQQ
  762-  781 (29.43/ 8.67)	QQQRERERE..QRD.R..........GRE....QLQQ
  930-  949 (40.68/14.72)	QQQHQQQQE..QQQ.R..........QQE....MQRQ
  950-  975 (29.51/ 8.71)	QQQQMEQMErlKQQ.R..........QQQelllQQQQ
  976- 1006 (30.87/ 9.44)	QQQQQQQQQ..QQQlRhhtpadtshyQQQ....QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.26|      13|      15|     175|     187|       2
---------------------------------------------------------------------------
  175-  187 (24.36/12.20)	HGQTI..NGHR.GNEA
  191-  204 (19.47/ 8.28)	HDEID..DHHEpGRNA
  206-  220 (17.42/ 6.65)	GGEDLlrNGME.LREA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.84|      15|      15|    1043|    1057|       3
---------------------------------------------------------------------------
 1043- 1057 (26.44/15.61)	NIQYWKVSARLAEKG
 1059- 1073 (25.40/14.73)	NISPSSVCQKLKSMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.30|      15|      34|     596|     614|       4
---------------------------------------------------------------------------
  596-  614 (21.66/22.08)	EHHHlslPySHLGLGLIKE
  631-  645 (32.63/17.59)	QHHH...P.SHHQLGLVDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.82|      30|      55|     407|     437|       6
---------------------------------------------------------------------------
  407-  437 (55.92/35.60)	KRRNQTRPMQCsDCHVLFPTG..HHLGW.HKR..TG
  439-  468 (34.67/16.75)	PSKAAKMPLQQ.....LFKQNivQFNNF.PKRvaAG
  469-  493 (37.23/18.52)	GARKPTAP....DLHI...NN..RKLGLaNKR..KG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.62|      49|     358|     499|     547|       8
---------------------------------------------------------------------------
  499-  547 (81.31/68.04)	LDAKKIALAKQLILREATTTVIANELNISRTFAWRLRKSLVNGVSLHER
  858-  906 (84.30/70.83)	IDDEKYAMAKLLVAQNSSTMEIARALNVSQMTAWKVRDAILKGVPLSYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.98|      32|      33|     224|     256|       9
---------------------------------------------------------------------------
  224-  253 (48.08/25.28)	......DDN..DVEEINHLNQHHSD...DGEITG..HAGHPKE
  254-  288 (36.46/21.66)	PfD......fnSIRLMQEYMQHQMNkfpNGSATG..PPGQDLE
  678-  713 (47.44/25.11)	P.DsdhIDH..DPFEGTENNEHHSN...GGR.PGsvSPAPPLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.56|      15|      15|      37|      51|      10
---------------------------------------------------------------------------
   37-   51 (28.58/15.85)	LPMIPIFGEDALWQK
   55-   69 (24.98/13.04)	LANVKISKNDTLPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.17|      14|      15|     303|     317|      14
---------------------------------------------------------------------------
  303-  317 (20.00/16.29)	DEEMSLPLIPEiELI
  321-  334 (25.16/15.49)	DEALGDPSNPN.DLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.81|      12|      38|     786|     799|      15
---------------------------------------------------------------------------
  786-  799 (19.71/14.56)	NGGMPMltRYPPSV
  827-  838 (20.10/ 8.94)	NTAAPV..PVPGSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32173 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AILKGVPLSYRNKRSDGRHSDEFSVKEQQQQQQQQQQHQQQQEQQQRQQEMQRQQQQQMEQMERLKQQRQQQEL
2) ALPVNLSLRSMPHMNSNESNGSSSSNTAAPVPVPGSSAASATVTPTGKKPRKPNVFIDDEKYAM
3) EGADPLEANAAADQAKSSGCSSGSGSSSGSGSSSTSSSSSSDDEDEDNEQEQDNDNDVVADEEQKRLQNGHGQTINGHRGNEADEIHDEIDDHHEPGRNAGGGEDLLRNGMELREANHEDDNDVEEINHLNQHHSDDGEITGHAGHPKEPFDFNSIRLMQEYMQHQMNKFPNGSATGPPGQDLELDLDQQHHDGDDDEDEEMSLPLIPEIELITPGDEALGDPSNPNDLVNGAGVG
4) QQQQQQQQQLRHHTPADTSHYQQQQQQQTTPKLLHPRRRLKAAERELR
5) SLHERVVDPSQEEQHLQQLQQQHHHQQIQLQHHQQDDQQQAAAAAAAQAEREREHHHLSLPYSHLGLGLIKEERQDSEDEEHQHQQQQQHHHPSHHQLGLVDECGADEIGAEETAGYMGDEDAVCGLLHNGYDPDPDSDHIDHDPFEGTENNEHHSNGGRPGSVSPAPPLQPPTLGNSGMPVPVQVHAAARPDVEAYKRLLAESQHFPHIVNAQQLQMQQQQREREREQRDRGREQLQQQKAHNGGMPMLTRYPPSVM
896
802
105
979
543
969
865
340
1026
800










Molecular Recognition Features






MoRF SequenceStartStop




1) EMSLPLI
2) LKSMGIHRRWKP
305
1069
311
1080