<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32172

Description "Checkpoint suppressor 1-like, isoform A"
SequenceMSTDNPTQLLTTRDLSQLRGHLQSGTVAVPSTTTSVVAAAAATVAAAHGYRTIAPPQQPANNSSTTTSATAASASASAQPPVIPPVISTSNSNMPASASKYVFLQHNHNGGFTAYDGSAATTAAGSTGTVGATSGNIVLLAAAPLEASSGEALVNVRTTEDDGELRSLSWLSDTNLIKGIVTTTAGQAGKRAATVAIKSATGAAGTVGSGAPNGNLCIVSDLIEELPTNLSETSEQESTGGAASGSAPAASTVYSTTTVHKGASGTTTVVEYKASKANQQQQNSPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTYLPTPTRTTMVGHGYMPVVVSSASQPILSPAKQQLPQQIYVTSNGSSPAGGGTIYKAASQALSSPTTSSSSSSNTTTHHPHKKYLREKMHVQMDHSSHVASTVTVVSSPASSNNSSISSSNTGSVSGSGSSTAAVNGGNSPVPKTSSFSTVFEAVNYATSAASNSSSSSNSTPNSQAILHGQESPAVVTTTTLISAGTLPPGYSFVNQVASTPHVLSTPAHVASPETPPGAALLPGTYYATSTTSAGTTTTTLQARSLQLSVSPPPPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYASYDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDPLVHTNNKPPYSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFPYFKTAPNGWKNSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQQRQNLIQALNRSPFFPNSAVDKISPSLKSPSGGSAYDSLDGGGSGSVSSAQPVAGGAGVPAAAAVALSTPTKSNGLALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNLSKAFRNIREDTVGQPMLQDALDDELSGDYHNNNNNNSGSKYNYMGANGSGGAGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPVITSSPSEDHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAYDSSEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHSLEEEHLQQHREQQLQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQQQIHQDMYSSTAGHNASMYLGGLNSHCLSGGGGVGVAAGMLPQHLSAATGASNKNKVKPLRGLRTKFKRKSAWMR
Length1268
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.535
Instability index55.38
Isoelectric point8.08
Molecular weight129966.80
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867
PubMed=26109357
PubMed=26109356
PubMed=25589440

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central
transcription regulatory region sequence-specific DNA binding	GO:0000976	IDA:FlyBase

GO - Biological Process
cellular response to hypoxia	GO:0071456	IMFlyBase
embryonic heart tube development	GO:0035050	IMFlyBase
mitotic G1 DNA damage checkpoint	GO:0031571	IGI:FlyBase
regulation of cell division	GO:0051302	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32172
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.91|      15|      15|     286|     300|       1
---------------------------------------------------------------------------
  278-  295 (28.80/12.96)	NQQQQnspQQQQQQQQQQ
  296-  311 (30.53/14.12)	QQQQQ..qQQQQQQQQQQ
 1144- 1158 (32.59/15.49)	EQQLQ...QQQQQQQHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     229.62|      51|      52|     467|     517|       2
---------------------------------------------------------------------------
  372-  427 (48.75/16.95)	..TIYKAASQALSS....PTTSSSSSSNTtthhPHKKYLrekMHV.....QmdHSSHVASTVTVVSS..
  429-  458 (34.44/ 9.59)	.............A....SSNNSSISSSN....TGS......VSG.....S..GS.....STAAVNGGN
  467-  517 (86.81/36.54)	FSTVFEAVNYATSA....ASNSSSSSNST....PNSQAI...LHG.....Q..ESPAVVTTTTLISAGT
  522-  576 (59.62/22.55)	YSF....VNQVASTphvlSTPAHVASPET....PPGAAL...LPGtyyatS..TTSAGTTTTTL.QARS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.23|      48|      52|     128|     178|       3
---------------------------------------------------------------------------
  128-  176 (75.13/55.18)	GTVGATSGNIVLLAA.APLEASSGEAlVNVRTTEDDGELRSLSWLSD...TNL
  179-  230 (70.09/40.76)	GIVTTTAGQAGKRAAtVAIKSATGAA.GTVGSGAPNGNLCIVSDLIEelpTNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     372.67|      51|      54|     592|     642|       4
---------------------------------------------------------------------------
  592-  638 (77.05/25.83)	............SQVHNG.....S..........L.......GGGGGGGGGS......GG.....G.GGGGGANL....RS...PNSYASY.....DN..EDSLKEF
  639-  692 (41.97/10.65)	DLVV.......sSRLHTS.....T..........PqysvsknGANGYGNGNS......NV.....N.GSGAGSNTpqkqKH...PNN.VPY.....D..........
  816-  852 (34.28/ 7.32)	.......................S..........L.......DGGGSGSVSS......AQ.....PvAGGAGV...........PAAAAVA.....LS..TPT.KSN
  853-  905 (42.27/10.78)	GLAL........A...NG....aS..........Q.......ATNAARPHSP......NG.....G.GSGSHARF....DPylfPNLSKAF.....RNirEDTVGQ.
  906-  974 (42.40/10.83)	PMLQdalddelsGDYHNN.....NnnnsgskynyM.......GANGSGGAGS......GGvgsnaN.GASDGINF....AR...LARDCGA.....DS..ID.....
  976- 1028 (35.58/ 7.88)	..............VHAA.....A..........A.mlylkhGPKIYSEPFQ.............N.GSGPVI.T....SS...PSEDHTYsaggnSN..ADSGSST
 1029- 1075 (54.08/15.89)	PLTN.......gNAL..A.....S..........V.......AQAVAQGQN..............N.QGGAGSDS....NC...ASSDAAY.....DS..SEENHNI
 1079- 1137 (45.05/11.98)	EMAD.......rQRHRDGvdallS..........L.......SGSSIVECGSvatthyHS.....N.G.SSGSSH....GS...PHKRAS..........SHSLEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.51|      22|      23|      54|      75|       5
---------------------------------------------------------------------------
   54-   75 (39.09/15.62)	APPQQPANNS..STTTSATAASAS
   76-   99 (33.41/12.28)	ASAQPPVIPPviSTSNSNMPASAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.31|      12|      15|    1214|    1226|       6
---------------------------------------------------------------------------
 1214- 1226 (19.13/16.04)	GGLNSHcLSGGGG
 1232- 1243 (23.18/12.74)	GMLPQH.LSAATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.80|      29|     877|     331|     364|       9
---------------------------------------------------------------------------
  312-  335 (24.65/ 8.82)	...........QQQQQ...QTTYLPTPTrttmvGHG...YM
  340-  371 (33.23/14.82)	SSASQPIlSPAKQQLP...QQIYVTSNG.sspaGGG.....
 1180- 1213 (38.92/ 9.26)	SSAAANV.ALAQQQQQqihQDMYSSTA......GHNasmYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.67|      10|      16|     789|     799|      10
---------------------------------------------------------------------------
  789-  799 (15.31/13.80)	RSPfFPNSAVD
  806-  815 (19.36/10.94)	KSP.SGGSAYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32172 with Med12 domain of Kingdom Metazoa
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