<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32153

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2027
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.06
Grand average of hydropathy-0.505
Instability index59.22
Isoelectric point6.35
Molecular weight226320.87
Publications
PubMed=11181995
PubMed=12777533
PubMed=15772651
PubMed=17081983
PubMed=18691976
PubMed=18669648
PubMed=19369195
PubMed=19690332
PubMed=21269460
PubMed=23186163
PubMed=24275569
PubMed=24129315

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32153
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     164.64|      15|      15|    1901|    1915|       1
---------------------------------------------------------------------------
 1901- 1915 (36.22/13.00)	QQQQQQQQQ....QQQQQQ
 1918- 1936 (30.62/ 9.93)	QQQQQQQQQyhirQQQQQQ
 1938- 1952 (32.75/11.10)	LRQQQQQQQ....QQQQQQ
 1953- 1967 (35.56/12.64)	QQQQQQQQQ....QQQQHQ
 1968- 1982 (29.50/ 9.32)	QQQQQQAAP....PQPQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     757.59|     218|     231|     196|     424|       2
---------------------------------------------------------------------------
   63-  287 (285.71/173.34)	.........GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPldhLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWS
  288-  520 (335.35/190.32)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAP...GPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSS
  523-  660 (136.54/68.46)	FEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ..........................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     508.19|     133|     231|    1472|    1623|       3
---------------------------------------------------------------------------
 1472- 1623 (203.20/133.05)	GERQSDSLEKV.RQLLP.LPKQTRdvITCEPQGSlIDTKGnkIAGFDSIFK.....KEGLQvsTKQKISPWDLFEGLKPSAPlswGWFGtVRVDRRvargeeQQrlLLYH......THLRPRPRA..YYLEP..LPLPPEDE..EPPA.PTLLEPEKKAPEPPKTDKPGAAP
 1636- 1726 (132.42/59.98)	GKKRSQP.......................................AT..K.....TEDY...............GMGPGRS...GPYG.VTVPPD..........LLHHpnpgsiTHLNYRQGSigLYTQN..QPLPAGGPrvDPYR.PVRL.PMQKLPTRP..TYPGVLP
 1734- 1854 (172.57/80.53)	GLEPSSYKTSVyRQQQPaVPQGQR..LRQQLQAK.IQSQG..MLGQSSVHQmtpssSYGLQ..TSQGYTPYVSHVGL.........................QQ.....H......TG....PAG..TMVPPsySSQPYQST..HPSTnPTLVDPTRHLQQRPSGYVHQQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.56|      25|      26|    1007|    1031|       4
---------------------------------------------------------------------------
 1007- 1031 (44.13/30.16)	CSEQDSEPGARLTCRILLHLFKTPQ
 1035- 1059 (43.43/29.54)	CQSDGNKPTVGIRSSCDRHLLAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     700|     714|       6
---------------------------------------------------------------------------
  700-  714 (26.85/17.03)	LEQITSFALG.MSYHL
  716-  731 (23.14/13.65)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.80|      17|      17|    1990|    2006|       7
---------------------------------------------------------------------------
 1990- 2006 (29.25/17.11)	QGLQQTQQQQQTAALVR
 2010- 2026 (31.55/19.21)	QQLSNTQPQPSTNIFGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.16|      16|      17|    1077|    1092|       8
---------------------------------------------------------------------------
 1077- 1092 (28.77/17.72)	LGDAE.LKGSGFTVTGG
 1096- 1112 (26.39/15.55)	LPEEEgGGGSGGRRQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1408|    1421|       9
---------------------------------------------------------------------------
 1408- 1421 (24.50/17.17)	LLEIIISGTV..DMQS
 1432- 1447 (20.20/12.81)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.16|      31|     202|     920|     952|      10
---------------------------------------------------------------------------
  920-  952 (54.27/33.12)	DIAILCAELTGYCK.....slSAEWLG..VLKALCCSSNN
 1114- 1153 (45.89/22.73)	NISVETASLDVYAKyvlrsicQQEWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.41|      26|     202|     759|     786|      11
---------------------------------------------------------------------------
  759-  786 (39.83/35.42)	SDLVGSYTTSLClCIVAVLRHYHaCLIL
  788-  804 (21.66/ 9.94)	QDQMAQVFEGLC....GVVKH.......
  967-  990 (39.92/25.59)	SDL..SFHDSLA.TFVAILIARQ.CLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|     874|     886|      12
---------------------------------------------------------------------------
  874-  886 (25.11/14.63)	ENPAA.HTFTYTGL
  892-  905 (21.03/11.11)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      15|    1175|    1189|      15
---------------------------------------------------------------------------
 1175- 1189 (21.57/17.24)	HRLLDNEDgENPQRQ
 1192- 1205 (26.45/15.66)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:29157917 PMID:30230586 PMID:27438523 PMID:26452386 PMID:26601288 PMID:22913342
prostate cancer	PMID:29157917 PMID:23836153 PMID:23661306 PMID:22610119 PMID:26924278 PMID:26383637
colon cancer	PMID:23178117 PMID:29507187
renal cell carcinoma	PMID:27050271
uterine tumors	PMID:31520353 PMID:26383637
Uterine leiomyoma (ULM)	PMID:33025089 PMID:23443020 PMID:30895261
endometrial polyps colorectal cancers	PMID:24980722
phyllodes tumors	PMID:25865354 PMID:30511242
extrauterine cancer	PMID:25595892
uterine smooth muscle tumors	PMID:28592321
colorectal cancers	PMID:23132392 PMID:28183795
castration-resistant prostate cancer	PMID:24938407
Breast fibroepithelial tumors	PMID:26437033
fibroadenomas	PMID:28513873
epithelial ovarian cancer	PMID:29735544
Thyroid Cancer	PMID:28634282
lung cancer	PMID:28055980
renal cancer	PMID:24504440 PMID:30895261
syndromic disorders Congenital heart disease	PMID:30905399
cardiovascular diseases	PMID:24751643
Alzheimer disease	PMID:21293490
Fragile X syndrome	PMID:31098807
uterine leiomyomas	PMID:25615570 PMID:32094355 PMID:25106763 PMID:30619444
Blepharophimosis	PMID:24715367
short humeri	PMID:24715367
hirschsprung disease	PMID:24715367
Goldberg-Shprintzen syndrome	PMID:24715367
Opitz-Kaveggia syndrome	PMID:24715367
breast fibroadenomas	PMID:25106763
pelvic inflammatory disease	PMID:28432313



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32153 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQ
4) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
534
474
1735
1582
573
521
1910
1733










Molecular Recognition Features






MoRF SequenceStartStop




1) NIFGRY
2) QQYHIRQQQQQQILRQQQQ
2022
1925
2027
1943