<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32146

Description Cdk-8-prov protein
SequenceMDYEFKSKLSAEREKVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSDQALQDLYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKAEKTQNQHQQQTATQQQTTVQQQVQQQNSSQTNGTGGTAGATLQHSQDSSLNQGPQNKKPRMGPSANNSSGPSLMPSDYQHSSSRMGYQSNVQGSSQPQNAMGYSTTSQQSSQYQSHRY
Length486
PositionKinase
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.09
Grand average of hydropathy-0.745
Instability index48.43
Isoelectric point8.65
Molecular weight55719.39
Publications
PubMed=27762356

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32146
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.51|      35|      35|     412|     446|       1
---------------------------------------------------------------------------
  375-  410 (46.38/24.06)	HQQQTATQQQTtvQ.QQVQQQNS.SQTNGTGGT.AGATL
  412-  446 (62.53/34.85)	HSQDSSLNQGP..Q.NKKPRMGP.SANNSSGPSLMPSDY
  448-  481 (44.60/22.87)	H...SSSRMGY..QsNVQGSSQPqNAMGYSTTSQQSSQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|     151|     165|       2
---------------------------------------------------------------------------
  151-  165 (26.77/20.72)	DLKPANILVMGEGPE
  189-  203 (28.67/22.72)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32146 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKAEKTQNQHQQQTATQQQTTVQQQVQQQNSSQTNGTGGTAGATLQHSQDSSLNQGPQNKKPRMGPSANNSSGPSLMPSDYQHSSSRMGYQSNVQGSSQPQNAMGYSTTSQQSSQYQSHRY
351
486










Molecular Recognition Features






MoRF SequenceStartStop




1) QYQSHRY
480
486