<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32140

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGDYDTNTLLINNLSAISFRVYEPVAANTASYTFQPQVVEDALRRDGHLVHVDTTRRCIWVFYLTTKDGSMLGPEERGLTAKMEVCGYSLGLSGEGGFEPSSLFRSRQLGTNSLNTPNSSSSAGSVVDAAFRNPQASAFPTAAGVMPGAPVMDNKGASHILSDSDRFAHVPLKEKYDFFITATLASLSSSLCHTIGAIPLDHRSILLPSQAYYLDEFILGPKPQSCALGTFRVYLTSTGTLVISLSVSLLEGLASFAELARSNMLPSNPVVLAAPLGAFGFMLNPVDGDMYGLDSGYGHSPDTQISRLKPDPTDRLSQWKATCCKVLQMRGISPSLINGCSWFNVHFLQRKPYEHRQDAKRPPLTNPPQIAAWPSVLCFRKPRIDAGADSRSSKALVASASESLDPVDDARQWCQGFPEREETIAKRKKERDEREALAAVSRSIADADSKNNQISAASPMALRRPSNGGAIAASSAMYPTPPDGIQPLGMAASAETGFAASPANQPQHNAMAGIDTVMKNNAPHTENFGNGWEGGDNKREQQAGNLLEGDNMFGDLGEDMFEGNELTDADFNFFDEQLNEQTEGVEMNFSAISGLGTTTDLSADAGQPTNSAPQTNNRVEDYKTIPQPAPPEFTKPELKHARSTLAEGSRQQANQESFNRNSTIGIKRPHSPFNRETVYKRIKASLLSPPKPRSPTTALSQRRKSEFDKVDFDPSLSLVNKKYTENGPFNYMIPAVQEMQKTRLELQNPLLTRVEKPPKEPPSNFGALLARIAHGIGGSLTGRDEVASETDDSSWASDPDDLSDESNYAPSLAKSGISRRRLDDDVLSTAASFKDLESAVADTPAYGSIDLVRLSHPEVPEFSIAKYFADPEPARLQVSFSDTNFITIAQILTEQVATGSLQIAPRILSRKPQDVRRTLAKAVRYSMQGLRKALPRSLADAIECSLKPYADVQDVPLVALAQPQRIQAKPMGSEMSTRNIYPIPTPHIEIRRYETPFSMLPTAISFWESLGLSPAKGAKDIVSVCLFPNVDGLRDSASAFLQRIRSVYESLKLGTFDILPTVPDLEDGLLSYFATQQPAVRDEWAVSPFNGPMSCLANALKSVQMTEKNYVVFFVYPDDRPNSVVESCAAFHDLYERYKQCMADIGKPVTSELVLQLVPLDCIASDTTVTVMSPVDYMKLCLETYDRCTLFGGPMPAPAIVLEPQVLRTIDFKLNTNPSPNLLQENSCMHVAYAQSVDERWITAAWTDYRGTRQMTTSYCLGRRDRPLTRSITEIIQQIWEATMDHIHFARVHWRVVVTKCSPMEQQEIEYWASLQQSETYANVSLTLLTVDTNPSLQLIPPAQRIQIPSAALSSNSPASTPQASVLSPDQSGLGPPTPIGTGSSNSANAATDNNNNSNNNNNTTTTTTTTTDTDADSTLVDQLDMTWAVIAAHRLNNSTSLTELNQALASGYLVKRGGPKLEDVPVTMEVNVIHCEGINIPQPHQYPRVYEQLLREMLSHFRGLGTLARARGVVDRETDVRPWHVAVAEKAVRALYLLM
Length1542
PositionKinase
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.353
Instability index47.89
Isoelectric point5.42
Molecular weight168951.36
Publications
PubMed=12712197

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32140
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     848.29|     230|     496|     261|     504|       1
---------------------------------------------------------------------------
  261-  504 (385.98/243.27)	LARSNMLPSNPVVlAAPLGA.FGFMLN.PVDG.DM.YGL........DSGYGHSPDTqisrlkpDPTDRlSQWKATCCKV.LQMRGISPSLINGCSWFN..VHFLQRKPYEHRQDAKRP....PLTNP..PQ..IAAWpsvlcFRKP...RIDAG.ADS...RSSKAL...VASASESLDPVDDARQWCQGFPER.EETIAK..RKKERDEREALAAVSRSIADA.........DS..KNNQISAASPM.A.LRRPSNGGAIAASSAM.....YPTPPDGIQPLGMAASAETGFAASP
  558-  709 (197.75/106.40)	LGE.DMFEGNELT.DADFNF.FDEQLNeQTEGvEMnFSA........ISGLGTTTDL.......................................................SADAGQPtnsaPQTN....................................................NRVEDYKTIPQPAPP..EFT.....KPELKHARSTLAEGSRQQANQ.........ESfnRNSTIGIKRPH.SpFNRETVYKRIKASLLS.....PPKPRSPTTALSQRRKSE..F....
  753- 1003 (264.56/145.14)	LTRVEKPPKEP...PSNFGAlLARIAH.GIGG.SL.TGRdevasetdDSSWASDPD........DLSDE.SNYAPSLAKSgISRRRLDDDVLSTAASFKdlESAVADTPAYGSIDLVR......LSHPevPEfsIAKY.....FADPepaRLQVSfSDTnfiTIAQILteqVATGSLQIAPRILSRK.....PQDvRRTLAKavRYSMQGLRKAL...PRSLADAiecslkpyaDV..QD......VPLvA.LAQPQRIQAKPMGSEMstrniYPIPTPHIE....IRRYETPFSMLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.59|      54|     857|     157|     215|       2
---------------------------------------------------------------------------
  157-  215 (80.22/68.63)	KGASHILSDSdRFAHVP.LKEKYDFF...ITATLASLSSSLCHTIGAIPlDHRSILLpsqAYY
 1018- 1075 (83.38/53.50)	KGAKDIVSVC.LFPNVDgLRDSASAFlqrIRSVYESLKLGTFDILPTVP.DLEDGLL...SYF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32140 with Med13 domain of Kingdom Fungi
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