<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32138

Description AGAP002523-PA
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGLSSGAGGTNAVTIPPPLSSPAGSMHSPAGGNPVVGGSMHAQQQQQQQQQQQQPISPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLYDLVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPEPQDASGKQPSIEAPDSKSEKQNDKPSKEGTAGTVAQPADSKPPKVNPYEMIFTEYLQCSHHRDVILQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPIPTRYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPLKPAESASAAGGSGGSGTGNMPSGLAAVDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLDEAGSPQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSQGICNAGLGTGPISNKPATSSSPNGGGGVEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMLDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGSGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELEQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFILNSPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSSNNSHNHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQQQQTLQQQQHLQQQQQQLHLQQQQAQQQQQLQQQQQLQQLQQQQQQQLQQQQQQQNQMMMQQQQQPNIPQQQQSALQQQQLGSQQGQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQQQPPQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQAGMGPMNPAMAGGTAGIGTAGGGAVMGAQGMGAGGMMGAQQTAQGQQGAGGIMNQSTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGSGGLGGASGMAGNSGMGASAGGMGGTSGGGMVTSGGMVTGGMGSAGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2812
PositionKinase
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.640
Instability index57.30
Isoelectric point6.84
Molecular weight307658.23
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32138
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     428.96|      17|      17|    2263|    2279|       1
---------------------------------------------------------------------------
 1993- 2006 (31.56/ 6.61)	QQMQQMQQQQQQQ...Q
 2007- 2023 (39.52/10.22)	QQQQQQQQHQQHQQQQQ
 2024- 2040 (31.81/ 6.72)	QQQMQQQQTLQQQQHLQ
 2042- 2058 (33.16/ 7.33)	QQQQLHLQQQQAQQQQQ
 2060- 2076 (34.05/ 7.74)	QQQQQLQQLQQQQQQQL
 2077- 2093 (34.55/ 7.97)	QQQQQQQNQMMMQQQQQ
 2196- 2212 (39.85/10.37)	QQQQQQQQQQQPPQQPQ
 2213- 2229 (30.42/ 6.09)	QAQQAQQAQQAQQQQPQ
 2263- 2279 (42.99/11.79)	QQQQQQQQQQQQQQQQQ
 2281- 2297 (42.99/11.79)	QQQQQQQQQQQQQQQQQ
 2298- 2314 (34.88/ 8.12)	QQQQQQQTQSQVQQQQQ
 2402- 2418 (33.19/ 7.35)	QQQQQQQAQQQQAQRNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     208.37|      24|      24|    2577|    2600|       2
---------------------------------------------------------------------------
 2235- 2255 (28.65/ 6.07)	G..F.VG...NV.NPMAQLAQQQG.GNQQ
 2453- 2477 (30.56/ 7.07)	GtaG.IGTA.GGG..AVMGAQGMGaGGMM
 2513- 2536 (32.53/ 8.10)	G..GsMIQT.GMMNPQQNPA.LVG.QGMG
 2539- 2561 (32.94/ 8.32)	G..G.LGGAsGMAGNSGMGASA...GGMG
 2577- 2600 (51.28/17.93)	G..G.MGSA.GIGNTAPMGAGGQG.GGMG
 2759- 2778 (32.41/ 8.04)	S..G.MGQG...GNAQGM.MQNQG.QGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.18|      18|      24|    2624|    2641|       3
---------------------------------------------------------------------------
 2335- 2352 (29.67/ 8.26)	GAQQGPQTQQQL....QQQQQQ
 2617- 2629 (27.66/ 7.02)	GNP.GMGM........QNMQQS
 2630- 2651 (28.85/ 7.75)	GNMQGGGMFQGQnvpyQNVNQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     235.21|      34|      34|    2116|    2149|       4
---------------------------------------------------------------------------
 2101- 2125 (39.16/12.11)	QSALQQ...QQLGSQQG....................................qQ.................QQQQVTMTP
 2126- 2163 (57.43/22.16)	QQTLQQ...MQNNSMGGMQ..........................MGGPMSSMnQ..............qhmQQQYGQANP
 2164- 2195 (29.51/ 6.80)	AQLVGQ......GNMGGMQ.................tgmgglgagMGGGMMNQ.Q.................Q........
 2317- 2377 (35.08/ 9.86)	QQ..GQqasQQQGPQQGPQqgaqqgpqtqqqlqqqqqqqqmfysgMGQATMNR.F.................DRPQLNTNS
 2378- 2426 (38.48/11.73)	KQALSN...ML.RSKLPIN..........................AGHPASFM.QqqqqqqqaqqqqaqrnpQQPFLR.GP
 2427- 2448 (35.53/10.11)	LR..........A...GMP...........................GNPIVG..A.................QAGMGPMNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.38|      29|      60|    2654|    2693|       6
---------------------------------------------------------------------------
 2654- 2688 (49.56/24.85)	NYG.............NQG.MGQQSGQGG..GMMGNfnpMAQQQrntQAEF
 2702- 2746 (39.81/13.08)	QYGqhapnvtmgnmgvNQGaVPPYPRQGGkpGVGGN...MPQNQ...QQQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.78|      13|      24|    1686|    1701|       7
---------------------------------------------------------------------------
 1686- 1701 (15.20/17.02)	LQNRdQSLetIGGIED
 1712- 1724 (24.57/12.73)	LQLR.YSL..VGGLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.15|      11|      19|    2485|    2496|       8
---------------------------------------------------------------------------
 2485- 2496 (18.49/12.39)	GQQGaGGIMNQS
 2502- 2512 (21.66/10.00)	GTTG.GSIMSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.37|      15|      19|    1606|    1623|       9
---------------------------------------------------------------------------
 1609- 1623 (27.03/21.80)	SKHKDGNGGNNSSSN
 1625- 1639 (26.34/10.40)	SHNHGANSNSSVSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.88|      13|      26|    1885|    1897|      12
---------------------------------------------------------------------------
 1885- 1897 (23.69/13.04)	ERKPLAYEETHRL
 1914- 1926 (25.19/14.35)	EPLPLPPEEVDPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.49|      27|      29|    1731|    1759|      15
---------------------------------------------------------------------------
 1733- 1759 (44.98/31.28)	TTDW..AILFAQLISQGVIDLSNNSELFT
 1761- 1789 (39.51/20.27)	TLDMlaTLIHSTLVSDSQTERDENKKLYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.66|      17|      19|    1837|    1853|      18
---------------------------------------------------------------------------
 1837- 1853 (28.48/20.07)	GNKIAI...DSIE.KKNGLRL
 1854- 1874 (21.18/12.69)	GDKQRVsvwDLLEgHKNPAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32138 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQGMGAGGMMGAQQTAQGQQGAGGIMNQSTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGS
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGL
3) GMGSAGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
4) GQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQQQPPQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSL
5) HEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGL
6) HNINLSSPEPQDASGKQPSIEAPDSKSEKQNDKPSKEGTAGTVAQPADS
7) LPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQ
8) MFSKHKDGNGGNNSSSNNSHNHGANSNSSVSSNGSTFG
9) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
10) SGAGGTNAVTIPPPLSSPAGSMHSPAGGNPVVGGSMHAQQQQQQQQQQQQPISPQEEQRI
11) TQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQAGMGPMNPAMAGGTAGIGTAGGGA
2468
824
2578
2114
194
378
1916
1607
1
228
2305
2538
859
2812
2262
226
426
2028
1644
35
287
2464










Molecular Recognition Features






MoRF SequenceStartStop




1) GGYGSLQQ
2) IMPAIV
3) MNMRPLKRPRLGPPDVY
4) YYEPL
2257
1980
1
1912
2264
1985
17
1916