<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32134

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQERIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRAIVGGSGAGEQQQAGEGSSGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGERNDRRLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKWEEEHEQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGGAGGATPGLNNGGDGTGPAGGGLTGSGDDGTMNGFNLSSLAKKRRMEDFCKSPKSDSNLSVGGGGGGGASDAVGTEKANTGAAGVAGATGATSSSSTTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGTSGASISTAGSSSKERDKERSEKKALHAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSLAAGTGGIGTGVNIGGFGGLKDSAKSGSGLLPSGGTSSLANCVSSTAGIAGAGKNKSVLSSSNSSFNPCFSLTHLSALTQSSSATSAPSLTAALTSGKASDGAFPSSTKSPHYTSSTSGSSKAPFQKSNSFGSLGGSGGTGLKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSSATGTASTGSSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQLSSTSPSGEASARLLDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGHTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length1753
PositionMiddle
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.261
Instability index51.19
Isoelectric point9.29
Molecular weight173757.45
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32134
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     520.99|      65|      65|     949|    1013|       1
---------------------------------------------------------------------------
  599-  674 (58.97/11.27)	SST......V..........SSGG.AGGG..............pGGGGGGGGGAGGA........T..........P...G............L......N.............NGGdgtGPAGGGLTgS..GDdgtmnGFNlS.........SLAKK.....RrmedfcKS....P.KS
  675-  756 (50.34/ 8.27)	DSN......L.........SVGGG.GGGGasdavgtekantgaaGVAGATGATSSSST.......T..........T...TTT..........ItsqdvgA.............AAS...GATGAGNS.S..EQ.......R.L.........QTGGA.....T......EE....D.TG
  877-  931 (59.73/11.54)	SST......V.KK......SS....SSSG...............GGSGSHRKTSDSS...........................................E.............RTS...SSKSEKKK.K..RK.....TDD.S.........AMGPP.....N......KL....P.YK
  960- 1024 (97.49/24.67)	SSP......V.HH......SSPKH.SGSG...............GPLGFHSPKHGSSV.......S..........P...KHP..........L......H.............SGG...SSTGGGKP.S..MS.....ALK.S........aA..AS.....G......SS....PgSK
 1025- 1106 (45.28/ 6.51)	SSD......V.............G.GGGG...............GTSGASISTAGSSSkerdkerS..........E...KKA..........L......H.............AAGsssSSSSGGRS.K..NS.....SLK.LkqldlaagsSMSIS.....M......AAgigdA.GS
 1107- 1185 (55.48/10.06)	SSP......V.APmidltgPVPGA.AAAL...............GGLGLPGPGMTTAS.......SmlqalqaaknR...KTP..........T......A.............AGG...STGLGGSL.SavID.....KLK.S.............A.....Q......SA....D.DE
 1276- 1348 (54.78/ 9.82)	LSA......L.TQ......SSSAT.SAPS...............LTAALTSGKASDGA.......F..........PsstKSP.................H.............YTS...STSGSSKA.P..FQ.....KSN.S.......fgSLGGSggtglK......AS......KV
 1526- 1600 (45.99/ 6.76)	SSDgsmfptA.GR......ASPGMlSGSA...............SRDGFRSG.GGSGS.......A..........P...GTP..........T......TtssmvlppfpspiSGG...ASNDGD...S..GT.....LMR.P.........P................SR....P...
 1601- 1675 (52.92/ 9.17)	SST......IsNH......SHSSQ.DGIG...............GG....SGNSGDAV.......A..........G...STPavasmasmmmM......N.............AMS...AAAGGGHT.QqlIA.....ALA.A........kSGVLP.....P......PP....P.NN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.57|      22|      22|    1363|    1384|       3
---------------------------------------------------------------------------
 1363- 1384 (33.18/ 8.70)	SS...AYSSKEKGGSTSGRSKSSSA
 1385- 1409 (29.63/ 6.77)	SSltgAMLTGATGGTGSGTGSSSSA
 1452- 1473 (31.76/ 7.93)	SS...ATGTASTGSSESGEAGSKSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.98|      16|      16|     825|     840|       4
---------------------------------------------------------------------------
  787-  801 (22.32/ 7.57)	MISAKNEPPSP.ALGA
  825-  840 (26.81/10.93)	TISGSGLEIIPLATSA
  842-  856 (24.85/ 9.46)	TVAASGFPS.PSVTSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.72|      24|      26|    1220|    1245|       5
---------------------------------------------------------------------------
 1220- 1245 (35.60/19.17)	GLKDSAKSGSGLlpSGGTSSLANCVS
 1249- 1272 (42.11/17.62)	GIAGAGKNKSVL..SSSNSSFNPCFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.77|      14|      16|     322|     335|       7
---------------------------------------------------------------------------
  322-  335 (22.88/12.59)	VLEASSANKLQI.QP
  338-  352 (18.88/ 8.76)	VVNAGSGSAASVlQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.04|      17|      20|     423|     441|       8
---------------------------------------------------------------------------
  423-  441 (23.90/22.23)	HASAgsVTDLA..KGLLVS.LP
  445-  464 (26.14/16.02)	HCYF..LTDNPslRGMMVSsIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.90|      12|      16|     757|     768|      10
---------------------------------------------------------------------------
  757-  768 (21.93/ 9.76)	GLPLFGETVPAA
  775-  786 (20.97/ 8.97)	GSSLGGTTTTNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.13|      15|      27|      76|      90|      14
---------------------------------------------------------------------------
   76-   90 (25.59/21.09)	QMELLMERLRTKA..KS
  104-  120 (20.55/15.34)	RMSLLEKRYALDAveKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.08|      13|      27|     479|     491|      19
---------------------------------------------------------------------------
  479-  491 (23.15/15.49)	RQQAVFNQLLSSC
  504-  516 (21.93/14.28)	RRLLVFEVSALSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.40|      32|     224|    1484|    1520|      20
---------------------------------------------------------------------------
 1484- 1520 (45.34/28.73)	QTPVTTAAPSvgSSPVRQLSSTSPSGEASarlLDGSL
 1711- 1742 (58.06/25.31)	KSPAPSPLPF..ASPHSNASSTHAAGAAG...LDDDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.67|      16|     339|      52|      69|      21
---------------------------------------------------------------------------
   52-   67 (28.95/13.13)	GGPSAGGTGTAGKVLL
  392-  407 (28.72/ 6.31)	GGSGAGEQQQAGEGSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32134 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQKFKPNVLGSSTVSSGGAGGGPGGGGGGGGGAGGATPGLNNGGDGTGPAGGGLTGSGDDGTMNGFNLSS
2) GSLPALLMANGGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKV
3) GTGLKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSAL
4) IAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALN
5) KKRRMEDFCKSPKSDSNLSVGGGGGGGASDAVGTEKANTGAAGVAGATGATSSSSTTTTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGTSGASISTAGSSSKERDKERSEKKALHAAGSSSSSSSGGRSKNSSLKLKQL
6) NPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSSATGTASTGSSESGEAGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQLSSTSPSGEASARLLDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVA
7) SPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAA
589
12
1340
1658
661
1412
1701
658
65
1410
1697
1085
1634
1736










Molecular Recognition Features






MoRF SequenceStartStop




1) GGGKGIGKPDIKPP
2) KERSEKKALHA
3) LIAALA
4) SALKSAA
5) SLKLKQLDLA
36
1052
1657
1009
1079
49
1062
1662
1015
1088