<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32132

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSSSSATDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPDPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAAAASTTGGPASPDGGLNAAPGCAPASPGGSASGTVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLSPAVILPERVWQDCIMHAPTPAATAASSSASSGTTATTTAPGSQQQQHTIGAAGSSSANATGGSSYTSISSPGGGGAAAAGGGGSLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHHHHHHHHRPQRVAFHKRPPQEALFRPGTEPLSLSAAAALAAAAAAAAAANAASSPGAVSSGDSAADSLELADTCLSGSGGGNSGASNTTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGGSSGGTTEGGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGGIGTNGMLMKGAAEASEALAEALSGGRPGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGSQGGTAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSIALDTLVDLQMSLSSGTGSGGGNGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQDQPDGQPESGGQGGAGAGPGRPVGVAGPTTTALGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGAGMLGSPAVGRQEDKSAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTTTAAGSTGSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPNPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2679
PositionMiddle
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.416
Instability index53.64
Isoelectric point6.06
Molecular weight280397.47
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.29|      25|      26|     908|     932|       2
---------------------------------------------------------------------------
  589-  612 (29.80/ 6.32)	SEGSPASAAPSP.MQPSSVSQPTSV
  754-  772 (30.81/ 6.87)	GAGGSCSLS.GGGSG.....GGVPM
 2056- 2079 (31.69/ 7.35)	SASASASL.GGGAAGASSLGGGSMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.75|      23|      27|    1334|    1358|       3
---------------------------------------------------------------------------
 1077- 1106 (32.11/ 7.92)	PHPNSSPGGG.GCLSDGGSIALdtlvdlqMS
 1336- 1364 (30.65/11.97)	PSPAGTSGGGlFHPGGMGGIPV..plrqgMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.93|      25|      25|     908|     932|       8
---------------------------------------------------------------------------
  908-  932 (47.98/13.96)	LSGGRPGTGGGS....DNGAPNNGAGCTP
 1284- 1312 (32.95/ 7.07)	LLGGLSGLNGGSlahpYSNPPSQGAQSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.98|      24|      26|     223|     246|       9
---------------------------------------------------------------------------
  224-  247 (42.57/13.14)	APGAAAAAASTTGGP.......ASPDGGLNA
  947-  968 (33.78/ 8.86)	QGGTAVGSAN..GGT.......PDRNGASAG
 2080- 2110 (34.63/ 9.27)	QPGGNAMGQNRPDGPgqspmppPPPSTPDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.91|      26|      26|    1417|    1442|      10
---------------------------------------------------------------------------
  541-  563 (29.84/ 8.53)	..DTCLSGSGGG.NSGASNT.TGAAPG
  567-  588 (31.78/ 9.71)	PY....GGPPSYCRNPMSIGdSHPLP.
 1417- 1442 (41.29/15.53)	PYDVAIASPANSVATPSSYH.SKQYPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      15|      15|     716|     730|      11
---------------------------------------------------------------------------
  716-  730 (24.77/ 9.52)	SNSSSNSSNSLSALK
  732-  746 (25.82/10.26)	SPRSSLSSSGIGSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.06|      12|      15|    1459|    1472|      12
---------------------------------------------------------------------------
 1368- 1379 (23.86/ 7.83)	PATPGGSM..RVPT
 1459- 1472 (19.20/11.25)	PSSTGGSGplGAGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.28|      25|      28|     258|     284|      13
---------------------------------------------------------------------------
  252-  277 (37.35/15.99)	APASPGGSASGTVVPADDAiEPREVL
  279-  303 (43.93/19.63)	APFAITGTLTGQSYRASDP.HTQKIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.10|      23|    1393|     305|     327|      16
---------------------------------------------------------------------------
  305-  327 (42.15/22.00)	DWSAFYPITNKHSGLADGADSMP
 1580- 1599 (24.75/ 8.49)	..SALAHLGLGGSSSAFGAGML.
 1691- 1713 (39.20/19.71)	DRGALATSAGGSSSSAAGGDSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.82|      47|    1393|     427|     506|      17
---------------------------------------------------------------------------
  432-  478 (85.64/62.67)	SLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHH..HHHHHHRP
  622-  670 (82.17/21.29)	SPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKsiNASPYHTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.60|      13|      19|    1380|    1392|      21
---------------------------------------------------------------------------
 1380- 1392 (27.94/14.16)	PQGSCPLPYPSPL
 1400- 1412 (24.67/11.43)	PMGSLSFRRTTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.52|      10|      14|     840|     849|      22
---------------------------------------------------------------------------
  840-  849 (15.85/11.10)	VKRMRLAAEE
  856-  865 (16.67/12.11)	IRNLDLYANE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.30|      43|     688|    1608|    1651|      24
---------------------------------------------------------------------------
 1608- 1651 (71.07/50.45)	EDKSAAVTINTDSlQNGYLDEDPIDCQCGFSAVVNRRMAHRAGL
 2298- 2340 (73.23/47.60)	EDQSWLLAVATDD.RGEFLETVTINIDIPNRGRRKRASARRYGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.38|      15|      20|    1188|    1207|      35
---------------------------------------------------------------------------
 1188- 1205 (19.78/27.43)	RQKQKEQaaaEREKQKQR
 1210- 1224 (25.59/14.11)	REREREQ...KQEQQQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.20|      48|    1855|      15|      62|      36
---------------------------------------------------------------------------
   15-   62 (88.92/50.71)	WRQL.VLGERPNAAGDPLDDP.VVRSYSK...CLAVDILCVWRR.VVAPKPKPK
 1866- 1919 (74.28/41.02)	WRQFhRLAGRGTGQCEPQPIPsLIVGYEKdwlSLAPYALHYWDKlLLEPYSYPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32132 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAANAASSPGAVSSGDSAADSLELADTCLSGSGGGNSGASNTTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGGSSGGTTEGGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRS
2) AAAPGAAAAAASTTGGPASPDGGLNAAPGCAPASPGGSASGTVVP
3) AEASEALAEALSGGRPGTGGGSDNGAPNNGAGCT
4) DGSQGGTAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSI
5) KQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPA
6) LAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPNPADGMRIDDDGKD
7) PAATAASSSASSGTTATTTAPGSQQQQHTIGAAGSSSANATGGSSYTSISSPGGGGAAAAGGGGSLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHHHHHHHHRPQRVAFHKRPPQEALFRPGTEPL
8) PLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQDQPDGQPESGGQGGAGAGPGRPVGVAGPTTTA
9) PSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTP
10) QINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
11) TLVDLQMSLSSGTGSGGGNGGGASSVPPIPNLGSPQEEPIDDWSF
12) WFTNMGVDQQRKNGTTTTTAAGSTGSSSSG
513
222
898
944
1266
2030
368
1161
1432
2512
1099
1985
749
266
931
1095
1426
2134
500
1254
1489
2553
1143
2014










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAA
2) REQKQEQQQ
509
1214
513
1222