<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32132

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSSSSATDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPDPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAAAASTTGGPASPDGGLNAAPGCAPASPGGSASGTVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLSPAVILPERVWQDCIMHAPTPAATAASSSASSGTTATTTAPGSQQQQHTIGAAGSSSANATGGSSYTSISSPGGGGAAAAGGGGSLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHHHHHHHHRPQRVAFHKRPPQEALFRPGTEPLSLSAAAALAAAAAAAAAANAASSPGAVSSGDSAADSLELADTCLSGSGGGNSGASNTTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGGSSGGTTEGGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGGIGTNGMLMKGAAEASEALAEALSGGRPGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGSQGGTAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSIALDTLVDLQMSLSSGTGSGGGNGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQDQPDGQPESGGQGGAGAGPGRPVGVAGPTTTALGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGAGMLGSPAVGRQEDKSAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTTTAAGSTGSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPNPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2679
PositionMiddle
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.416
Instability index53.64
Isoelectric point6.06
Molecular weight280397.47
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.29|      25|      26|     908|     932|       2
---------------------------------------------------------------------------
  589-  612 (29.80/ 6.32)	SEGSPASAAPSP.MQPSSVSQPTSV
  754-  772 (30.81/ 6.87)	GAGGSCSLS.GGGSG.....GGVPM
 2056- 2079 (31.69/ 7.35)	SASASASL.GGGAAGASSLGGGSMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.75|      23|      27|    1334|    1358|       3
---------------------------------------------------------------------------
 1077- 1106 (32.11/ 7.92)	PHPNSSPGGG.GCLSDGGSIALdtlvdlqMS
 1336- 1364 (30.65/11.97)	PSPAGTSGGGlFHPGGMGGIPV..plrqgMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.93|      25|      25|     908|     932|       8
---------------------------------------------------------------------------
  908-  932 (47.98/13.96)	LSGGRPGTGGGS....DNGAPNNGAGCTP
 1284- 1312 (32.95/ 7.07)	LLGGLSGLNGGSlahpYSNPPSQGAQSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.98|      24|      26|     223|     246|       9
---------------------------------------------------------------------------
  224-  247 (42.57/13.14)	APGAAAAAASTTGGP.......ASPDGGLNA
  947-  968 (33.78/ 8.86)	QGGTAVGSAN..GGT.......PDRNGASAG
 2080- 2110 (34.63/ 9.27)	QPGGNAMGQNRPDGPgqspmppPPPSTPDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.91|      26|      26|    1417|    1442|      10
---------------------------------------------------------------------------
  541-  563 (29.84/ 8.53)	..DTCLSGSGGG.NSGASNT.TGAAPG
  567-  588 (31.78/ 9.71)	PY....GGPPSYCRNPMSIGdSHPLP.
 1417- 1442 (41.29/15.53)	PYDVAIASPANSVATPSSYH.SKQYPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      15|      15|     716|     730|      11
---------------------------------------------------------------------------
  716-  730 (24.77/ 9.52)	SNSSSNSSNSLSALK
  732-  746 (25.82/10.26)	SPRSSLSSSGIGSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.06|      12|      15|    1459|    1472|      12
---------------------------------------------------------------------------
 1368- 1379 (23.86/ 7.83)	PATPGGSM..RVPT
 1459- 1472 (19.20/11.25)	PSSTGGSGplGAGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.28|      25|      28|     258|     284|      13
---------------------------------------------------------------------------
  252-  277 (37.35/15.99)	APASPGGSASGTVVPADDAiEPREVL
  279-  303 (43.93/19.63)	APFAITGTLTGQSYRASDP.HTQKIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.10|      23|    1393|     305|     327|      16
---------------------------------------------------------------------------
  305-  327 (42.15/22.00)	DWSAFYPITNKHSGLADGADSMP
 1580- 1599 (24.75/ 8.49)	..SALAHLGLGGSSSAFGAGML.
 1691- 1713 (39.20/19.71)	DRGALATSAGGSSSSAAGGDSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.82|      47|    1393|     427|     506|      17
---------------------------------------------------------------------------
  432-  478 (85.64/62.67)	SLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHH..HHHHHHRP
  622-  670 (82.17/21.29)	SPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKsiNASPYHTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.60|      13|      19|    1380|    1392|      21
---------------------------------------------------------------------------
 1380- 1392 (27.94/14.16)	PQGSCPLPYPSPL
 1400- 1412 (24.67/11.43)	PMGSLSFRRTTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.52|      10|      14|     840|     849|      22
---------------------------------------------------------------------------
  840-  849 (15.85/11.10)	VKRMRLAAEE
  856-  865 (16.67/12.11)	IRNLDLYANE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.30|      43|     688|    1608|    1651|      24
---------------------------------------------------------------------------
 1608- 1651 (71.07/50.45)	EDKSAAVTINTDSlQNGYLDEDPIDCQCGFSAVVNRRMAHRAGL
 2298- 2340 (73.23/47.60)	EDQSWLLAVATDD.RGEFLETVTINIDIPNRGRRKRASARRYGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.38|      15|      20|    1188|    1207|      35
---------------------------------------------------------------------------
 1188- 1205 (19.78/27.43)	RQKQKEQaaaEREKQKQR
 1210- 1224 (25.59/14.11)	REREREQ...KQEQQQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.20|      48|    1855|      15|      62|      36
---------------------------------------------------------------------------
   15-   62 (88.92/50.71)	WRQL.VLGERPNAAGDPLDDP.VVRSYSK...CLAVDILCVWRR.VVAPKPKPK
 1866- 1919 (74.28/41.02)	WRQFhRLAGRGTGQCEPQPIPsLIVGYEKdwlSLAPYALHYWDKlLLEPYSYPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32132 with Med13 domain of Kingdom Metazoa
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