<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32131

Description AGAP006046-PA
SequenceMSADLRIVKLFEEVVEDKNIVPNFDEEEQRKKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEAAQGGQGAAGGTGMNEHEGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPVPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYINLVRRMQDTMDGKNIFAGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMAALPEAYWSVIYERMQEALGSKAMKEWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITDSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVADITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAAAAGGGAGGAATATGQGVAGAGPGVGPPPGGVAAGAPGATQGVVASGQAAPGTAAGPQQPQQVVGVVGNQNVALQQQLQQQQMGQGIQSHH
Length1450
PositionTail
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.097
Instability index45.28
Isoelectric point7.47
Molecular weight164334.50
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function 
ECO:0000256	ARBA:ARBA00003861
	 href='https://www.uniprot.org/unirule/RU364143' style='color:#FF0000;'>RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central
GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32131
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1198.96|     319|     327|     666|     992|       1
---------------------------------------------------------------------------
  410-  732 (353.91/236.09)	...LYDILY..PE...KE.P......LPvPDNNNP.NCTHQMAPTCiwIHLMKRAQT...ENYNiNRpvpIALRLHFEYLQHLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFSR..PMQALIDTILGNSKNPQ............ANmVGGGQPLPtaplsmR...VLDslTIHS.....KMS...LIHS...IVMHMIKQAQnkssipNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLAS......VPHTNqmqLH.......S.......CVE.....................STALRLIIG.LGSV.EVQAQLSRYVSEPKPPGNIVSGESEELNRALILTlarsmhITGTGNDPQSSAWC
  733- 1055 (524.21/345.58)	KDLLQNIMVNTPH...AW.PQHTLYcFP.PVLNEF.FMQHNIPKES..KQLLKKTVD...EEYR.NW...ASMTNENDIIAHFGM.TVNPPLF.........LCLVFKMIIETDGISP..VAYKILERIGARALSTHLRKMCDYLLFEVAN.SGGGAHVN......K...CVD..TINDMiWKYNII...TIDR...LVLCLILRTL......DGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDES......VSHPS...LPVY..FGNV.......CLRFL.PVLDIIVH.RYLEVPTQLSKTLDVILDhLGSLyKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGT......VVGSLKDVRPENWA
 1057- 1344 (320.85/201.09)	TEAYQAYMMTKESdnvNWvPELSYY......INLVrRMQDTM..DG..KNIFAGT.DwrfNEFP.NP...PAHALYVTCVELLGL.PVGPSVV.........ANSIIDVLVKGYPVVPngVIHNWANTIG..LIMAALPEAYWSVIYERMQ.EALGSKAM......KewtYRQ..SPFDM.FNFKIVkeaMLDRsyvTVLAIVHSIF......H......HFGIGQLATI.TDSIKE.KLKPLV......H....................TEYQLIYLCHVVGPFLHRLSieraraVADIT...LMLYelLEQVdkaqpaqPLRYMdPICDLLYHiKYMFVGDTMKTELEAIIR.RLRP.ALQMRL.RFI............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      14|      44|     330|     344|       2
---------------------------------------------------------------------------
  330-  344 (24.75/16.71)	NEHEGdQSHTQWIWL
  376-  389 (27.31/13.85)	NLRRG.RDHLMWVFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.14|      25|      47|    1353|    1379|       3
---------------------------------------------------------------------------
 1353- 1379 (39.59/30.90)	GvdQNAAAAAGGGAGGAATATGQGVAG
 1385- 1402 (30.76/16.95)	G......PPPGGVAAGAPGAT.QGV..
 1404- 1427 (36.78/21.19)	...ASGQAAPGTAAGPQQPQQVVGVVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32131 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TATGQGVAGAGPGVGPPPGGVAAGAPGATQGVVASGQAAPGTAAGPQQPQQVVGVV
1371
1426










Molecular Recognition Features






MoRF SequenceStartStop




NANANA