<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32129

Description AGAP001358-PA
SequenceMMNPNHSGASRRPYSRGAVPRNRSRMPFSPHHSHHANRNHGGHNQSWYNKDMENSFNYGAGPSHIDRHRINMGGNSMQERNRHTMSASSIDRHLNHFEGPSNSTRGADLHGGDARSVLSMDSMRNSRDNNGGARERFSPHYHPGGGSGGGGGSGGGNGSGPAGGSNQGSSPPYCPVDGIGGNGGIKSDSPSRKRRRVSSRLPSQSPPAAIWEQRRSPRNGGGMMSLMGTSGANGGGNGQGSNGGLGNHGMNGHHSMSQQQQQQQQPQSSQSGQQQQLVPPQLHHRDHPQPHHHHPMHHHHHHSQQQQQQQQQQQSHHHTNGGGSHLHPSSGGGLAAAVISQLQSHAHHPQGSPPIRRPRFHRDQQSQQQQQPQQQQQQQPQQQQRPWESLTQVFQQAPAAQAQHQHPASSLMVDINQVPVSLPLGHHHEQLWTYSAGPHISICSGHPAAPHLPPCQVHGVYSQPFAQTCGIGGHFGGFASSAGPALAVPHPPPHQAHYQHPHLAQQRTDGLTLDGLEHAGGSPLHLSPLATHAHHLHGASPQMTQLTAAAQPIYISTEGRNYEILHRTVRRAITAPRRNFARFHWPGPPPPPPPPPPPAHHQHHHPGHHPTHHHRPHAPPPPAALQAHPQPLGHPQPAHVTLSATTSAYSGILLNFLAMFPLSSYGPPDLNSPDSNETENYEALLSLAERLGEAKPRGLARPEIDQLPSYKFNAETHTGDQTSCVVCMCDFEARQILRVLPCSHEFHAKCVDKWLRSNRTCPICRGNASEYFESSEEQ
Length778
PositionKinase
OrganismAnopheles gambiae (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-1.006
Instability index70.10
Isoelectric point9.37
Molecular weight84721.05
Publications
PubMed=12364791
PubMed=14747013
PubMed=17210077

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32129
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     673.21|      75|      77|     239|     313|       1
---------------------------------------------------------------------------
    2-   54 (63.75/10.02)	...........MN.P.......NHSGASRRPYSRGA.............V.............P.......RNR.SRMPF........S..PHHsHHAN..RNHGGHNQS.WYNKDMEN
   60-  140 (72.99/12.75)	AGP.SHIDRHRINmG.......GNSM.QERNRHTMS.............A.SSIDRHLNHFEGPsnstrgaDLH.GGDAR........S..VLS.MDSM..RNSRDNNGG.ARERFSPH
  145-  240 (79.40/14.64)	GGSGGGGGSGGGN.G.......SGPAGGSNQGSSPPycpvdgiggnggiK.SDSPSRKRRRVSS.......RLP.SQSPPaaiweqrrS..PRN.GGGM..MSLMGTSGA.NGGGNGQG
  241-  313 (135.34/31.17)	..SNGGLGNHGMN.G.......HHSMSQQQQQQQQP.............Q.SSQSGQQQQLVPP.......QLH.HRDHP........Q..PHH.HHPM..HHHHHHSQQ.QQQQQQQQ
  317-  376 (78.52/14.38)	HHTNGG.GSH....L.......H............P...............SSGGGLAAA.VIS.......QLQsHAHHP........QgsPPI.RRPR..FHRDQQSQQ.QQQPQQQQ
  418-  473 (73.42/12.87)	VPVSLPLG.H............HH..EQLWTYSAGP.............HiSICSG......................HP........A..APH.LPPC..QVHGVYSQPfAQTCGIGG
  476-  548 (86.31/16.68)	GGFASSAG.PALA.V.......PHP.PPHQAHYQHP.............H.LAQQ.RTDGLTLD.......GLE.HAG.G........S..PLH.LSPLatHAHHLHGAS.PQMTQLTA
  549-  618 (83.48/15.85)	AAQPIYISTEGRN.YeilhrtvRRAITAPRRNFARF.............H.WPGPPPPPPPPPP.......PAH.HQHH.........H..P.G.HHPT..HHHRPHA...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.52|      28|      31|     643|     673|       2
---------------------------------------------------------------------------
  643-  673 (37.46/39.72)	SATTSAYSGiLLNfLAMfPLSSYGPPDLNSP
  675-  702 (48.06/32.17)	SNETENYEA.LLS.LAE.RLGEAKPRGLARP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.42|      10|     228|     396|     408|       3
---------------------------------------------------------------------------
  378-  387 (22.26/ 8.30)	QQP...QQQQRPW
  396-  408 (15.16/10.45)	QAPaaqAQHQHPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32129 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APRRNFARFHWPGPPPPPPPPPPPAHHQHHHPGHHPTHHHRPHAPPPPAALQAHPQPLGHPQPAHVTLSA
2) MMNPNHSGASRRPYSRGAVPRNRSRMPFSPHHSHHANRNHGGHNQSWYNKDMENSFNYGAGPSHIDRHRINMGGNSMQERNRHTMSASSIDRHLNHFEGPSNSTRGADLHGGDARSVLSMDSMRNSRDNNGGARERFSPHYHPGGGSGGGGGSGGGNGSGPAGGSNQGSSPPYCPVDGIGGNGGIKSDSPSRKRRRVSSRLPSQSPPAAIWEQRRSPRNGGGMMSLMGTSGANGGGNGQGSNGGLGNHGMNGHHSMSQQQQQQQQPQSSQSGQQQQLVPPQLHHRDHPQPHHHHPMHHHHHHSQQQQQQQQQQQSHHHTNGGGSHLHPSSGGGLAAAVISQLQSHAHHPQGSPPIRRPRFHRDQQSQQQQQPQQQQQQQPQQQQRPWESLTQVFQQAPAAQAQHQHPASSLMVDINQVPV
3) SAGPALAVPHPPPHQAHYQHPHLAQQRTDGLTLDGLEHAGGSPLHLSPLATHAHHLHGASPQMTQLTAAAQPI
575
1
481
644
420
553










Molecular Recognition Features






MoRF SequenceStartStop




NANANA