<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32113

Description YALI0F03575p
SequenceMSREVPNNSLGPQGMGMQQHNWQSEVSPDERKNLIIILVKAIKALGPTYAQERIVPLARQYENLIFMNSISKSDYMNQCKNKVKEISDTVMQHRGRQMAQGQQSHQQNPQMMNFDPQQMLKTQQQTQPPQQAPQQQSQSQQQHQKKDDFQWGDGGSFQNFFFSDSGQGQQQNAPQQQQGGNMGGNMNGLNLGGMNMNMNMGQQNQQQQQQQTPQQQQNTPQQPNQMMNMNMTMGMMPQGQNQNQGQGQGQGQGQSQGQNQGQGQNQGQNQGQNQGQSQSQNQQQNQNQSQGQGQGQQTQGQPPTQALINFLQAQGIAPTPQTVQMFQSMPREQQQQYIAMHRKQRAAQQQKQQAAAQQQRMMQGQATQGMGAQGMGAQGGMGAQPQGQQGQPQGQNQNQGQGQQGQQGQQGQQGQQGQQQGQPGQPGQGNMRMSAAQIQAAAQIQAATQAGQAAAMRIDVRNLPIPQQILDEIPVVPKGVNTWAQIHELLKNETIPKSAMSAIKSAHQTHTRWVQMRMRQRQAQQQQAAQQGGMGGMSQSQQGGVPQGQQVGQPQGGQGGMSGGHMQMKPQGQAQGVQQQRMMQQQNQGQGQGQQQQQQQQPQAHRQAQHIDLTGGTGGFVSPQIKTTPNMASQQLQSQQQPHVKTTPQLQQPAISPMMATAPPGGAATAAGVAAAQAATKNPTAANPAAATAGRPADGTIPTMPGTLPIREADRQRLQQIYEEASRIPVQLHNFNDQLSPEQKRHIQEHIQTVHTMYQRIDQLAPMFFFLSKNPTATQRLIQLKCMFKEQLEGLRQGNYLTTPQILEKTKYEINRYFTFVRDNLQQRRPGGQGQGAQQPGQPGQQPGIQPGVQSGQQVPQQLGQQPGVQGQPGQGPQGQPQPTGMPPQAGMNMNMQNMMMQKQQQQQQQQGGPQMMGMMPGQQGQQGPGPQGQMNPMMQRKMQQQQQQQQQQQQGNMPDQAGQIPQQGGVPQGQMPPQQTQMPQGGLPQGGMPQVPPGQQPNAQQQQFFMQQQQFRPGQQGPGGPQQGPGPQQGPQQGPQQGPGPQQGPQQGPAPQQGPGGPPQPGQPGNFMFNQMYMQGGAPGMSQGGPPGAMPQVGPGAMPQTVPGTNLPPGAALPLGAFPPGVTSTPPLSSTQPVAKVSPKDKRGGAKPAARGKKVSANSTPIPAAATTPSGGPGKASPSGVPTYSATGPNLAPDQLKMPATRKRKSSAGLDDKRSPMPPAKKEKLEEAKVRETSEIAAKKEQLQRENPLGFFISSLGEALDVPAEEIAAFGGVSFKVGGKNPSALVAGNPGVVAAAANGVNGTPGPAAGPAVAAATAAAAGFTPGTAAAAGAGAGSGLGLTPSSLLKTPMPFDKGTAASTGDLAGSTGGASSSSSIETAVAAVPWTGLVSAASLKSAFQALECFKVSEVQFLTPPEEHNKLPKSKEVKTENPKDDKVPVPKLNGAQLFSSGDNMWDFDSIANGVSQEDLDKEFWTFEM
Length1483
PositionTail
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Dipodascaceae> Yarrowia.
Aromaticity0.04
Grand average of hydropathy-0.953
Instability index61.17
Isoelectric point9.78
Molecular weight158143.71
Publications
PubMed=15229592

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32113
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.96|      28|      29|     239|     267|       1
---------------------------------------------------------------------------
  387-  409 (49.05/ 7.07)	GQ...QGQPQGQNQNQGQGQQGQ...QGQ
  912-  939 (48.87/ 7.00)	GGPQMMGMMPGQQGQQGPGPQGQM.NPMM
 1033- 1057 (43.03/ 7.12)	QQGPQQGPQQG...P.GPQQGPQQgPAPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     808.47|     126|     145|     136|     280|       5
---------------------------------------------------------------------------
  117-  237 (205.82/35.00)	...QQMLK......TQQQ........................TQPPQQ.apqqQS.QSQQQHQKKDDFQWGDGGSFQNFFFSD.............SG...QG.............QQQNAPQQQQGGNMGGNMN....GLNLG.................................................G........MNMNMNMGQQNQQQQQQQT.PQQQQNTPQQPNQ............MMNMNMTMG....MMP
  257-  372 (168.72/26.44)	GQNQGQGQNQGQNQGQNQ........................GQSQSQnqqqnQN.QSQGQGQGQQTQGQPPTQALINFL................QA...QG.............IAP.TPQTVQ...MFQSM.....PREQQ.................................................Q........QYIAMHRKQRAAQQQKQQA.AAQQQ.......R............MMQGQATQG....MGA
  373-  518 (94.90/ 9.42)	...QGMG.AQGGMGAQPQgqqgqpqgqnqnqgqgqqgqqgqqGQQGQQ....gQQ.QGQPG.......Q...........................PG...QGnmrmsaaqiqaaaQIQAATQAGQAAAMRIDVR....NLPIP.................................................QqildeipvVPKGVNTWAQIHELLKNETiPKSAMSAIKSAHQ............THTRWVQMR....M..
  519-  623 (135.47/18.78)	RQRQAQ.QQQAAQQGGMG........................GMSQSQ................................................QGgvpQG.............QQVGQPQGGQGGMSGGHMQmkpqGQAQG.................................................V........QQQRM.MQQQNQGQGQGQ..QQQQQQQPQAHRQ............AQHIDLTGGtggfVSP
  624-  739 (106.51/12.10)	..QIKTTPNMASQQ.........................................lQSQQQPHVKTTPQ......LQQPAISPmmatappggaataAG...VA.............AAQAATKNPTAANPAAATA....GRPAD.................................................G........TIPTMPGTLPIREADRQRL.QQIYEEASRIPVQ............LHNFNDQL........
  740-  901 (97.06/ 9.92)	............................................SPEQ.....KR.HIQEHIQTVHTMYQRIDQLAPMFFFLS.............KN...PT.............ATQRLIQLK..CMFKEQLE....GLRQGnylttpqilektkyeinryftfvrdnlqqrrpggqgqgaqqpgqpgqqpG........IQPGVQSGQQVPQQLGQQP.GVQGQ..PGQGPQgqpqptgmppqaGMNMNMQNM....MM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     173.58|      38|      41|    1059|    1097|       6
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  943-  978 (42.47/ 6.94)	M.Q...............................QQQ..........QQQQQQQQGN.MPDQAGQipqQGGVP...QGQmPP.
 1000- 1025 (37.14/ 6.26)	...............................................QQPNAQQQQFFMQQQQFR.......PG..QQG.PGG
 1026- 1093 (58.31/17.01)	.PQqgpgpqqgpqqgpqqgpgpqqgpqqgpapqqGPG..........GPPQPGQPGNFMFNQMYM...QGGAPGMSQGG.PPG
 1290- 1338 (35.65/ 6.79)	LVA..............................gNPGvvaaaangvnGTPGPAAGPAVAAATAAA...AGFTPGTAAAA.GAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.00|      17|      17|    1162|    1178|       9
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 1162- 1178 (33.11/14.94)	ANSTPIPA.AATTPSGGP
 1181- 1198 (25.88/ 9.85)	ASPSGVPTySATGPNLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.51|      16|      16|    1413|    1428|      10
---------------------------------------------------------------------------
 1413- 1428 (28.79/17.86)	EVQFLTPPEEHNKLPK
 1431- 1446 (27.72/16.91)	EVKTENPKDDKVPVPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.37|      15|      28|    1339|    1353|      11
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 1339- 1353 (25.08/14.76)	AGSGLGLTPSSLLKT
 1369- 1383 (23.78/13.53)	AGSTGGASSSSSIET
 1387- 1401 (23.51/13.28)	AVPWTGLVSAASLKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.35|      16|      21|    1448|    1463|      13
---------------------------------------------------------------------------
 1448- 1463 (30.37/19.70)	NGAQLFSSGDNMWDFD
 1467- 1482 (28.98/18.44)	NGVSQEDLDKEFWTFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32113 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FTFVRDNLQQRRPGGQGQGAQQPGQPGQQPGIQPGVQSGQQVPQQLGQQPGVQGQPGQGPQGQPQPTGMPPQAGMNMNMQNMMMQKQQQQQQQQGGPQMMGMMPGQQGQQGPGPQGQMNPMMQRKMQQQQQQQQQQQQGNMPDQAGQIPQQGGVPQGQMPPQQTQMPQGGLPQGGMPQVPPGQQPNAQQQQFFMQQQQFRPGQQGPGGPQQGPGPQQGPQQGPQQGPGPQQGPQQGPAPQQGPGGPPQPGQPGNFMFNQMYMQGGAPGMSQGGPPGAMPQVGPGAMPQTVPGTNLPPGAALPLGAFPPGVTSTPPLSSTQPVAKVSPKDKRGGAKPAARGKKVSANSTPIPAAATTPSGGPGKASPSGVPTYSATGPNLAPDQLKMPATRKRKSSAGLDDKRSPMPPAKKEKLEEAKVRETSEIAAKKEQLQ
2) NKVKEISDTVMQHRGRQMAQGQQSHQQNPQMMNFDPQQMLKTQQQTQPPQQAPQQQSQSQQQHQKKDDFQWGDGGSFQNFFFSDSGQGQQQNAPQQQQGGNMGGNMNGLNLGGMNMNMNMGQQNQQQQQQQTPQQQQNTPQQPNQMMNMNMTMGMMPQGQNQNQGQGQGQGQGQSQGQNQGQGQNQGQNQGQNQGQSQSQNQQQNQNQSQGQGQGQQTQGQPPTQALINFLQAQGIAPTPQTVQMFQSMPREQQQQYIAMHRKQRAAQQQKQQAAAQQQRMMQGQATQGMGAQGMGAQGGMGAQPQGQQGQPQGQNQNQGQGQQGQQGQQGQQGQQGQQQGQPGQPGQGNMRMSAAQIQAAAQIQAATQAGQAAAMRIDVRNLPIPQQILDEIPVVPK
3) PPEEHNKLPKSKEVKTENPKDDKVPVPKLN
4) VNTWAQIHELLKNETIPKSAMSAIKSAHQTHTRWVQMRMRQRQAQQQQAAQQGGMGGMSQSQQGGVPQGQQVGQPQGGQGGMSGGHMQMKPQGQAQGVQQQRMMQQQNQGQGQGQQQQQQQQPQAHRQAQHIDLTGGTGGFVSPQIKTTPNMASQQLQSQQQPHVKTTPQLQQPAISPMMATAPPGGAATAAGVAAAQAATKNPTAANPAAATAGRPADGTIPTMPGTLPIREADRQRLQQIYE
818
81
1419
480
1249
478
1448
723










Molecular Recognition Features






MoRF SequenceStartStop




1) AARGKKVSA
2) EFWTFEM
1154
1477
1162
1483