<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32094

Description "General RNA polymerase II transcription factor, putative"
SequenceMSSNFYTSSHNRYWLLTRPSLLESRQTDLKYCTSRQLYCLFIFFSQLIQKLGKRLLLRQIPIATACVFFKRFYFKNSLCETNPYLVLAACIYVAAKVEETPVHIKSVVSEAKLVFHEHNIKMFPAETNKLGEMEFYLLEDLDFHLVVFHPYRALLHLTGRESADMGKFEKSRVQEDMEIRKKEGDAKKMREEEAKKASSKGQQPTVGQALEKEGERLEEAEETRIRRLMSRGTGEGMMEVDEGVLQISWFILNDSYRTDAPLLYPPYIIALSAIYIAFCLTSMSNSSARTRASSTQRPELLQSASINEGLNLLPPPKNAAEFLAGFQVSLPMLFGCVQEIIGLYPVWEAFEPTVMRNSQAQAKTGNAAAPVPAATGTKTGQNNDLVQDKKDKFGLEEAESLVRKMIEERMIDLGHPDNAGVEKASGTGPSNVAGKKRAR
Length439
PositionKinase
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus neoformans species complex.
Aromaticity0.09
Grand average of hydropathy-0.328
Instability index48.90
Isoelectric point8.04
Molecular weight49461.26
Publications
PubMed=15653466

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IBA:GO_Central

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32094
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.11|      20|      28|     182|     201|       1
---------------------------------------------------------------------------
  182-  201 (32.04/26.00)	KEGD.AKKMREEEAKKASSKG
  212-  232 (28.08/21.75)	KEGErLEEAEETRIRRLMSRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.81|      18|      47|     369|     390|       2
---------------------------------------------------------------------------
  369-  390 (24.31/26.28)	APVPAATGtkTGQNNdlVQDKK
  419-  436 (32.50/19.74)	AGVEKASG..TGPSN..VAGKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.51|      30|      69|     261|     291|       3
---------------------------------------------------------------------------
  262-  291 (55.26/42.55)	LLYPPY......................IIALSAIYIAFCLTSMSNSSARTR
  312-  363 (45.25/27.90)	LLPPPKnaaeflagfqvslpmlfgcvqeIIGLYPVWEAFEPTVMRNSQAQAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.83|      21|      32|     114|     134|       4
---------------------------------------------------------------------------
  114-  134 (38.17/27.88)	VFHEHN..IKMFPAETNKLGEME
  147-  169 (33.66/23.71)	VFHPYRalLHLTGRESADMGKFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32094 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRKKEGDAKKMREEEAKKASSKGQQPTVGQALEKEGERLEEAEETRIRRLMSRG
2) SQAQAKTGNAAAPVPAATGTKTGQNNDLVQDKKDK
179
358
232
392










Molecular Recognition Features






MoRF SequenceStartStop




1) SNVAGKKRAR
430
439