<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32092

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPDILNQAPATPSSALYATHILHLPKDRIYIHRYALSSAPGASTKDVVEDKMAKFWRDIADRAGNGKRLLEGPVATIVGQIERELWCFACKEDGISPPDGINEIQPPLPPLVPLELLSCPDHSSSYNCLSESSCDVTLNLEGETRKAWELLANALIETFAWKGGRRIILRDSGVVPFTPPFKPSLYPFTSGSLLLSLLPSRSPTSLLPPYPIPTHTLIPLSLPSILITTVLTPTPAQIARLNQTFDTLLGPGWKTGREQRVVREFVFGFGAETGTVSEMQEKGGEEEGWGVFWVPLLKKTSESGDKGVLTVWPIHLALPLPSDSFSHNPSATATPPSTQLKQSGRTEEGEQGLMQTAYSLFDFLASYREPSVPPEGDGGQLDDQDPDYDNELSLGDTDADMNETDGEGLNLQETGMGAGGDIEMEPTPKGGSDIDDLFSSSSPTPTPNMNVSSQPHSNKSPPPQQAQDGSNNAQDGEEDFMNSLVSVRDPSPPAQSQVMGIGDRGREKEVEVEITEDDFAFFDSPAAEEGDGIGMDVDMSIDSGINQSVPDGAIDHGGEIGAEPSIGQEKGLLAEEMVKTASPKITEEAGQDELTLVPLVGNGMEVDGIPPEPLPLPSVETAAKELQPPQLPIPPQPSSSPPILETSPKTPEQLASQSPHLTSPSIPLVPAAAPSNPLIPISFQPLPLLPPSHSSSSYPYCSTYGFAPPSPASTPESSLLARLTSYQTQYHSRPGSDAPSASQGQGATRRLSSKPKSTYADAWFSLSGGDDDGDGEDGDEDDMDSQTYTCPPTPMSQMEEMTTEIGSDAGSSDVDGVTGTDIDSGATGLMGVKDDDGEIKEDDGEIEWKGTKCIGSEWVILRDHPRLVQPKGEAENEIGWKVESVWDEAWGTLPSAVSGKKDSTKAKENLKEKKVKDVNWTKVVQEIIGNRAFRKSVLDPEDEYEQSSAWMGSLLEGDALCEVFGSDVLPVNLPQPQVNATSPSTAHIIRLSIAALSYWSQLGLEPQGGKKDVKMFIICKDSDEALGKMLGEGVKLGWEEERYGKAEFSGVVKGKMEDFGELAIGITEQSTGSVNTIVYLLTPPSQIPLNIYSSLIPNSPNTLLIPVPTPSNPSTSFVHEQYLTLVRTAYDRLPTFLRPIYVRGEPLRVSEEDAWIQCPAWVLARKEAVKPEFVMTWPVDEYDVLNRWRMWHVCYDVVSSTSLGPGALVVWVGDDRGETGHVRVFEDVGGWKEGMEKTCAYGREIAGRWNLEWRLSVCRAGIMAKEELQAWKDILKGKTWPITLLTSEAPSPLNPSYQKTPPKVRAIANIGPSILSDSSTRIIDTALSAQLTVLPLPLPLELSSDKGSPQIIYPRRTFLLTTPALDVSQHYTTKYHILSHQTPDGRKDQEDGGIVAEIAEEYHRLGCLARERWEGQGWLDSVRWGRALLEKR
Length1432
PositionKinase
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus neoformans species complex.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index55.66
Isoelectric point4.59
Molecular weight155661.68
Publications
PubMed=15653466

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32092
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.80|      23|      27|     186|     211|       1
---------------------------------------------------------------------------
  189-  211 (39.81/21.98)	TSGSLLLSLLPSRSPTSLLPPYP
  213-  235 (40.55/14.42)	PTHTLIPLSLPSILITTVLTPTP
  674-  691 (27.69/ 6.36)	PSNPLIPI...SFQPLPLLPP..
  693-  711 (29.74/10.15)	..HS..SSSYPYCSTYGFAPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.78|      25|      61|     766|     790|       2
---------------------------------------------------------------------------
  376-  393 (20.45/ 6.24)	.......GD..GGQLDDQDPDYDNELS
  766-  790 (47.43/25.74)	LSGGDDDGD..GEDGDEDDMDSQTYTC
  795-  821 (30.89/13.79)	MSQMEEMTTeiGSDAGSSDVDGVTGTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.43|      56|      68|     822|     880|       5
---------------------------------------------------------------------------
  822-  880 (93.35/80.43)	IDSGATGLM..GV..KDDDGEIKEDDGE.....IEWkgTKCIgSEWVILRDHPR.LVQPKGEAENEIGW
  885-  950 (78.08/54.77)	VWDEAWGTLpsAVsgKKDSTKAKENLKEkkvkdVNW..TKVV.QEIIGNRAFRKsVLDPEDEYEQSSAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     442.96|     174|     653|     395|     633|       6
---------------------------------------------------------------------------
  132-  184 (35.76/ 8.07)	SSCDVTLN.LEGETRKAWE..LLANALIETF.AWKGGRRI..ILRDSGVVPfTPPFKPS.....................................................................................................................................................................................................................................
  242-  375 (162.33/70.96)	...........................................................lypftsgslllsllpsrsptsllppypipthtliplslpsilittvltptpaqiarlNQTFDTLLGPGWK....TGREQRVVREF.................VFGFGaETGTVSEMqEKGGEEEGWGVFWVPLLKKTSESG.......DKGVltvwpihlALPLPSDSFSHNPSATATPPSTQ........L.KQSGRTEEGEQGlmQTAYSLFDFLASYRE.PSVPPE
  395-  612 (244.87/197.37)	GDTDADMNeTDGEGLNLQEtgMGAGGDIEMEpTPKGGSDIddLFSSSSPTP.TPNMNVS.........................................................SQPHSNKSPPPQQaqdgSNNAQDGEEDFmnslvsvrdpsppaqsqVMGIG.DRGREKEV.EVEITEDDFAFFDSPAAEEGDGIGmdvdmsiDSGI........NQSVPDGAIDHGGEIGAEPSIGQekgllaeeMvKTASPKITEEAG..QDELTLVPLVGNGMEvDGIPPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.25|      17|     721|     613|     631|       7
---------------------------------------------------------------------------
  613-  631 (23.45/18.68)	PLPLPsVETAAKElQPPQL
 1335- 1351 (31.80/15.95)	PLPLP.LELSSDK.GSPQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.90|      17|      27|    1027|    1044|       8
---------------------------------------------------------------------------
 1027- 1044 (28.62/19.37)	GKM..LGEgVKLGWEEERYG
 1054- 1072 (26.28/12.63)	GKMedFGE.LAIGITEQSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.49|      14|      27|    1073|    1086|       9
---------------------------------------------------------------------------
 1073- 1086 (24.64/14.48)	SVNTIVYLLTPPSQ
 1099- 1112 (25.85/15.63)	SPNTLLIPVPTPSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.07|      14|      29|    1138|    1153|      10
---------------------------------------------------------------------------
 1138- 1153 (21.34/18.80)	RPIYVRGEPlrVSEED
 1170- 1183 (28.73/18.06)	KPEFVMTWP..VDEYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32092 with Med13 domain of Kingdom Fungi
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