<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32090

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMSLDHQHLPSPAPTPSAAPPNPAVGPAMTGAPPDQAAIRTAVENQLLQLSQDLYEMEISAGHVKENRETAVADYMENINKAFINLSNLAGQMTDSVPHQIIENVDRYKNPHVYTRQTITRATGENQYALGRVLGLESFRRQLHDAISSDFPEIPLPERRHQPIKTSQEEDAPQEGGSTMPNGYSVKIEDGAGPDGQNGQSIVNGMSS
Length207
PositionMiddle
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus neoformans species complex.
Aromaticity0.04
Grand average of hydropathy-0.673
Instability index60.61
Isoelectric point4.98
Molecular weight22504.65
Publications
PubMed=15653466

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364146
GO - Cellular Component
chromatin	GO:0000785	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.52|      28|     158|       6|      34|       1
---------------------------------------------------------------------------
    6-   34 (49.97/24.47)	QHLPSPAPTPSAAPPNPAVgPAMTGAPPD
  167-  194 (51.55/21.79)	QEEDAPQEGGSTMPNGYSV.KIEDGAGPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.18|      26|      27|      40|      65|       2
---------------------------------------------------------------------------
   40-   65 (41.05/32.85)	TAVENQLLQLSQDLYEMEISAGHVKE
   69-   94 (42.12/33.87)	TAVADYMENINKAFINLSNLAGQMTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32090 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISSDFPEIPLPERRHQPIKTSQEEDAPQEGGSTMPNGYSVKIEDGAGPDGQNGQSIVNGMSS
2) MSLDHQHLPSPAPTPSAAPPNPAVGPAMTGAPPDQAAIRTAV
146
1
207
42










Molecular Recognition Features






MoRF SequenceStartStop




1) TMPNGYSVKIEDGA
178
191