<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32089

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNGISEQRSSPKTVFEDLRLSIDPTTIRLALGEKPVKSIDPDGTIAYDETKTPDAKLTEQLERIWNEYPNGLLELTERKLERLPPDEDAVKPQGEGVDEEKKRDPFSMMTYEEMEKLRSEIFLQLNDARNELWFVLELAKTLSSSSSFTTQPPPPPAALHQKKGKAKPAPPAPTTLPSIPGEPPILPPGTFSTTPSDFPIKPPHAQIYELERLLQAKRIALNECQGLIDGAVGELRLMAHAGDRFWKDIRNLKEGEGGRGQWAVVPKPDFGRVGGEGEKAKDVVIPYAIDEAPSGTRARCLAGFDLDPTKKDGLTFGDRHHLRLRATLRDDSGAVISSTPVKVEDQSDVRAMMEAAQMEAFDEDLFNEIRFAAARIPKNETEPQRVSFPVADKILSFELYDTRSLPSSPTSSICDIIVSSTRLSLLNIHRQRKINLVAPSQNFASPIPSILLPIIDTLRFRQLCSLVSSTLNGFDRTLRDAGLDSRMEKRMLKDGQDEIKEMRAVLLGKRGAEVLTGEYSLGIDDSYIITINISAPYNTIVYLSSISFPLANPDELSQVVSDDLSVQLLRLASRHLHGKLADEHKKGLYFDSLEEVIRIGETGLLRLSIPASFHTIYGSVESDWISVQAYDSRQSDITVFAWLDTVTHAIESSLSSNGSTTQVR
Length664
PositionHead
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus neoformans species complex.
Aromaticity0.06
Grand average of hydropathy-0.384
Instability index44.96
Isoelectric point5.25
Molecular weight73724.74
Publications
PubMed=15653466

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32089
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.91|      63|      95|     434|     511|       1
---------------------------------------------------------------------------
  434-  511 (87.09/89.85)	INLVAPsQNFASPIPSILLPII..........DTLRFrQLCSLVSSTLNGfdrtlrdaGLDSRMEKRMLKDGQDEIkemraVLLGKRG
  531-  603 (99.82/63.83)	INISAP.YNTIVYLSSISFPLAnpdelsqvvsDDLSV.QLLRLASRHLHG........KLADEHKKGLYFDSLEEV.....IRIGETG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      14|      15|     151|     165|       2
---------------------------------------------------------------------------
  151-  164 (29.59/12.58)	QP.PPPPAALHQKKG
  167-  181 (24.17/ 9.49)	KPaPPAPTTLPSIPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.43|      26|      95|     103|     129|       5
---------------------------------------------------------------------------
   40-   79 (32.40/ 9.48)	DPDGTIAYDEtktpdaklteqLERIWNEYpngLLELTERK
  104-  129 (46.03/25.13)	DPFSMMTYEE...........MEKLRSEI...FLQLNDAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.65|      41|     105|     187|     232|       8
---------------------------------------------------------------------------
  187-  232 (68.30/60.20)	PPGTFSTTPSDFPIKPPHAqiyelERLLQAKRIALNECQGLID..GAV
  293-  335 (68.36/47.81)	PSGTRARCLAGFDLDPTKK.....DGLTFGDRHHLRLRATLRDdsGAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32089 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTERKLERLPPDEDAVKPQGEGVDEEKKRDPFSMMT
2) SSSSFTTQPPPPPAALHQKKGKAKPAPPAPTTLPSIPGEPPILPPGTFSTTPSDF
75
144
110
198










Molecular Recognition Features






MoRF SequenceStartStop




NANANA