<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32088

Description Uncharacterized protein
SequenceMHGPIHQHLSGGCLAMLMQLGKELVEKQEQSMPQFHERSFRIPGRVIYTDNKRLGFLADLGNRDIPLHWLMRNQIPHGFKGVELLDVMFSPLTTVRQPPPNLAPMDPIPIDRAIWLIRVIGSNDIAAHRARQHQTAASVPAPSPAAATPSSTTTVTATPAMPVSSNDWYSQEFTNTVISWLRIQLGQLALPNTVKVAGKLPATKAGSGILQDEKARAKWLAKWDYSTRLLRALHTKHLISTRLFTGWLADHLTHVNLAQLGFLAQLIGEYLDDLVHHLGSARHCLRAACDKLVEVRNSPGKELLQKVEDMLITVIKALYEANPDVLLSPSTWRLHSPLLATILSTSSPQWENLKRRNEALAFKPTVTAGSSNPRRQRMEEIQKLDSICKDTDMRQLTFLFFDGAASPTCSPVDLVKFEEKVFTLLNWSMGLFQLGAHRPYAVYTLLKHWHEQQEEHQASQAKLGKRQHIDLFQVVYKWLDTAPAARNEDNVRAIGITIGELTRRGMFSYGRYLQTLIANGHTARNLRSASDDRSHHLALLKSMPVFVMAKDLLQQRRIALSGDDLEVRRRDELEEKAVLAAFEEQVKEYVPEVYGLESYGQSEALKTMVNYEIPASSQLTRYLYVFARFSIAANAGATLRSDGERRAMDASTFARITQVFRQSHGYATIADFMVRALQEAEDDEILDVILDIIKRDADVWTAMDLWPRLGDKLLDRHHALERKGKEHPRLVQLLKVLAQKKRLMPDDEDEVKQLQTSVDKSTSPPAGVKLVDVFEVLPHILTTGKENTAISVAPALFRQCGRFSSWSLKWWTLIVDVVQKAGNTEQKPFLYHVISTHLSAVLGQHGDSLDDAVTSWLENLSAANVVETFGGRTRPAGVLVRLLLFLVSHRFLSTWVVLEKAVFPIWKHAAPFALPPRKRLSSKQIQAITSTVNIIAQLLISPPLIPDLAPVSLKESLIVQASRQPVLQGSSVGILIQHLPLLVVFEQSKLLPDQVSHRIDEILRNLAMTAEFKTAAFRNLNLLKDAFLAREWSGPGMDQGLEGKMIDVLKRIMSEKPTQPSPKQGLPNFDTSARFSAWRWTRVVLEMRVEFKALTMRIAEGQNVAEAKQTLNQLVHATLDRETTADDTDLLCEVFKGVDSMVTQEILAAGMERLATLLGHAIAAESQQQLETHIKSIDQLLRILDSMNNLPSQSVTEPSVLNARHKLLDLLALALQTVERNLSTTRDGSDLLLPPGISPPQPSHLLKAVMGLLKFTLGSVVSESVSLTAPKPNFPHLAVCFLKAIFAGDGILDSNSARIMADMLVYIIDCTSPQARLVCQSALLAETVSPHAQSILSSFPELSAAMPYLSPVQRHMSLVTPDTADHVSDSALPLDDRRWELFEYIGPSKRKIGPQDLFLASAPLKDASSIPITLFDPKITRDAPPNAGTMDAYGKPAEDGELSPTTDPNPASPVEEEPRRSWETFASERNLGDGLAGEPAYAKQAATLLFSVRDNDVLEVAPVKSAPELVITSSTSPQKPKVKRSGSGKDKATGSNKDAPAAAEEDENDEDSGAEVPLSKKQKTAKNNNAAAKAPARKTTGGKGVSKKATGKSAKEGATGKAKGGRRKSQAE
Length1612
PositionKinase
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Cryptococcus> Cryptococcus neoformans species complex.
Aromaticity0.06
Grand average of hydropathy-0.230
Instability index47.21
Isoelectric point8.43
Molecular weight178187.31
Publications
PubMed=15653466

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32088
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     316.56|      90|     203|     979|    1069|       1
---------------------------------------------------------------------------
  979- 1050 (103.09/52.21)	......................................................LPLLVVFEQSKLLPDQVSHRIDEILRNLAM.TAEFKTAAF..RNLNLLKDA...FLAREWSGPGMDQGLEGkMIDVLK
 1051- 1136 (87.64/40.62)	RIMSEKPTQPSPKQGLPNF....................dtsarfsawrwtrvvLEMRVEF..................KALTMrIAEGQNVAEakQTLNQLVHA...TLDRETTADDTDL.....LCEVFK
 1137- 1254 (97.26/45.82)	GVDS.MVTQEILAAGMERLatllghaiaaesqqqlethiksidqllrildsmnnLPSQSVTEPSVL...NARHK...LLDLLAL.ALQTVE.....RNLSTTRDGsdlLLPPGISPPQPSHLLKA.VMGLLK
 1259- 1336 (28.58/ 8.45)	SVVSESVSLTAPKPNFPHL.avcflkaifagdgildsnsarimadmlvyiidctSPQARLVCQSALLAETVSPHAQSIL.....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.11|      16|      16|     280|     295|       2
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  280-  295 (27.67/21.05)	S.ARHCLRAACDKLVEV
  298-  314 (20.44/13.30)	SpGKELLQKVEDMLITV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.48|      51|     204|     220|     272|       3
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  220-  272 (80.79/66.83)	LAKWDYSTRLLRAlHTKHLISTrLFTGWLADHLTH.VNLAQLGF.....LAQLIGEYLD
  424-  480 (83.69/59.27)	LLNWSMGLFQLGA.HRPYAVYT.LLKHWHEQQEEHqASQAKLGKrqhidLFQVVYKWLD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.23|      51|     204|     352|     406|       4
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  352-  406 (72.51/59.67)	NLKRRNEaLAFKpTVTAGSSNPRRQRMEEIQKLDSICKDTDMRqlTFLFFDGAAS
  566-  616 (82.72/51.90)	EVRRRDE.LEEK.AVLAAFEEQVKEYVPEVYGLESYGQSEALK..TMVNYEIPAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32088 with Med12 domain of Kingdom Fungi
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