<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32078

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGCITNVRVIDGFSNVYWRIYTEDTSGTNPPGDGPNNGHTLLKHISRLKELELRLRSQGSLVLIYPRRLGLLIFSATPDFEHLAPVLLSESGDQTNRLLVGSTILKVWTSGSVSAADLAKSHLSDLQTTNANSPAPSQRLQNNSVQPRRADNSGGSAAIYASFISAVTAAFSLQIVRQNNAIPLGPRTLFNTVNGNLDDGQGPAGNGSTSVSALTSLHVQLTSAGKLTIALQTIAQTGLLRLSQPEESASAILPGADLWLAPTGSIARLITSHSEKNSHSRPTSASEDIRRWQLNVLEWLGYFGLPTEPVTDDGWVEVEVWEPFYSRLSGEAARLKEENSSLPLKRILWPAIYCFRRSKSNQSETLDRTGESFPFLCDPLDFAEGWCAKEIPKAVETKSELPSKNQERQVNSQDTSSPGPVGLPEGIESLSRASLHPEVQSANLVYPTPPDGTAGIGLNPVVPTTTKNALDPDTTMDFGPAAGLGVGSGLYDTNEDDDLFGDMNEKDFGTKGITDADFSFFDDQNFDQPSNGGNMEDIQESPGFIESNKPDVPLGPSDLVSSSPVSVDRNNTPKGSLEQIHPAPVPHGQPLSVNDALVLSPHQDHAQTASPPLSPVEVKKILFPESSTSPKSLAKTSNALSHYSPVAFKSNISSWDQKYGADGKFSFMGVRTAFNHDPHTSSDGIPTIGLPRRKSHMKALAYSKKADAEGSPVDEVDSASSPDSESESDDGCDNTGPENTMPYMTLTTLKRKRAVSSPINSPKPSSVMSSIGAEQEVNMPRSEDSIFIGNFLSIFSDLSIAGFFTLSENHIFPSLASREIQVQVAQLLVDQVTQSSLDHKIDGRFSVSCLDNQPSWSRELLEGSEYLGGIEKLDLNSFVSLQEQNAQNFLSPDAGPAPRQNLQHKDTGRGSITKLSPPHLRVRRGKDFLETLPPAISFWETFDLEPAHGPKDITAYCIHPQFSTRAANVFLDRLGLLYPSCNLGSHSRGENIDACRNGLVEWDVKSVKRPNYQTAVQQLKLICEELGTALLDGMPSKDNIVVYIINPFSHAASLVDICAAFWTLLQNYFASAEKPPKQVDEVLLQIVPLDFVMSAESLVVPPQAEYLNLALEVYSRCSTRQMQPSLVNCAPPVMLAETLPPSIGFRLASERFSPLQEGRCLHVACSRSQDQRWMTVAWSDNSGALQRTMSYCLRFRNSTASRTLSAVRSEIWAATRDIMDKSQGRWRVIIVNTDNVDQDEYDTWLNLADQYNKSRSMAIELAILSVNTAFDISLSPPPSPLSMSLLNPQASSTPIATPVPSGSILSPDGPGNAPTPPSGANAANNALTPTDSLLESESESLLVDICDESWCVLLSHRLNGNLHLTEYRPALASGYLVRRRGTTDADGAYTMNVNLLFTQRPSTHYETTLREIIGMYRDLATLARVRGTRIVQTGTLPWHIATAMRAQEILSYVL
Length1458
PositionKinase
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.325
Instability index53.26
Isoelectric point5.16
Molecular weight158784.11
Publications
PubMed=16372000
PubMed=19146970

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32078
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     795.03|     200|     205|     470|     671|       1
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  186-  296 (73.05/32.04)	..............................................................................................IPLGPRTLFNTVNGNLDDG.QGPAGNgSTSVSALT.SLHVQLTS.AGKL.TiaL...QTIAQT..GLLRLSqPEESASA.ILPGADlwLAPTgSIARliTSHSEknSHSRPTSASEDIRRW............
  470-  671 (337.54/186.06)	TKNALDPDTTMDFGPAAGL....GVGSGL.YDTNEDDDLFGDMNEKDFGTKGITDADFSFFDDQNFDQ..PSNGGNMEDIQESPGFIESNKP.DVPLGPSDLVSSSPVSVDRN.NTPKGS.LEQIHPAP.VPHGQPLSVNDAL.V..LSPHQDHAQT..ASPPLS.PVEVKKI.LFPESS..TSPK.SLAK..TSNAL..SHYSPVAFKSNISSWDQKygADGKFSF
  676-  851 (227.31/118.91)	TAFNHDPHTSSDGIPTIGLprrkSHMKALaYSKKADAE.GSPVDEVDSASSPDSESE....SDDGCDNtgPENTMPYMTLTTLKRKRAVSSPiNSP.KPSSVMSS..IGAEQEvNMPR.S.EDSIFIGNfLSIFSDLSIAGFF.T..LSENHIFPSL..ASREIQ..VQVAQL.LVDQVT..QS...SL..........................DHK..IDGRFSV
  856-  968 (124.99/61.14)	.......................NQPSWS.RELLEGSEYLGGIEKLDLNSF....VSLQEQNAQNFLS..PDAG.......PAP...RQN...................LQHK.DTGRGS.ITKLSP....PHLRVRRGKDFLeT..LPPAISFWETfdLEPAHG.PKDITAYcIHPQFS..T............................................
 1275- 1335 (32.14/ 9.11)	.............................................................................................DISLSP....PPSPLSMSLL.N.PQAS.STPI.ATP.VPSGSILSPDGPG.N..APTPPSGANA..ANNALT.PTD..........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     201.33|      60|    1028|     122|     181|       2
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  122-  181 (98.89/56.77)	LAKSHLSDLQTTNANSPAPSQRLQNNSVQPRRADNSGG..SAAIYASFISAVTAAFSLQIVR
 1151- 1212 (102.45/59.09)	LASERFSPLQEGRCLHVACSRSQDQRWMTVAWSDNSGAlqRTMSYCLRFRNSTASRTLSAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.21|      17|     287|    1053|    1069|       3
---------------------------------------------------------------------------
 1053- 1069 (32.29/23.59)	SHAAS.LVDICAAFWTLL
 1340- 1357 (28.92/20.24)	SESESlLVDICDESWCVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.29|      49|     708|     383|     431|       4
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  383-  431 (87.36/49.52)	PLDFAEGWCAKEIPKAVETKS...ELPSKNQERQVNSQDTSSPGPV....GLPEGI
 1092- 1147 (77.92/43.33)	PLDFVMSAESLVVPPQAEYLNlalEVYSRCSTRQMQPSLVNCAPPVmlaeTLPPSI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32078 with Med13 domain of Kingdom Fungi
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