<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32077
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAEFQTALSTFESRLNSLVTSLTTSPTASGAPKAAQELLNADDSLTSTIDTLKQHQSNYARILQLRAEAQSLEDKVKDIVRLVVRYEKDIREACGDSDSDSDTDYDSEESDHDMNAPHTTQTRTSRKRNEVDYRLLLDFARRISKYNHEAAADAAAGMAKGNHVLAGRDTEMTGVNTNGNQEGSPAEPVAAVTKEATSWLDESANMTRQVYMLPYPMEDRIRMGLMGQIQLAAAEGRPGFDPDKEVERLIREAEGVGIADAVAPPPIGEEATRVNEAAMAAAHAGSTASGGRMAPVQPKPKATLDLDLYDPDEDED |
Length | 317 |
Position | Middle |
Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus>
Aspergillus subgen. Nidulantes.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.651 |
Instability index | 39.28 |
Isoelectric point | 4.63 |
Molecular weight | 34441.57 |
Publications | PubMed=16372000
PubMed=19146970
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP32077
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 199.68| 60| 66| 187| 246| 1
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187- 246 (104.27/55.84) AEPVAAVTKEATSWLDESANMTRQVYMLPYPMEDRIRMGLMGQIQ..LAAAEGRPGFDPDKE
254- 315 (95.41/50.58) AEGVGIADAVAPPPIGEEATRVNEAAMAAAHAGSTASGGRMAPVQpkPKATLDLDLYDPDED
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