<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32067

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGRTMIQVSFSWIRLPSKVRSLVHSLLLVALMSLYADPLVVSASGSVTSKELVKNLSAEPVHAATNSQGLQRRQNGPNPPRRTDGHGSSAAIYASFISAVTGALSLQLIRCNKAIPLGSRTLFTVVAEDYYDNPRIDNDNPAAVPSLTTLQIQLTSLGKLTVSLQTISQPGILRLCGPYDTSVGAHNAHPGCDLWLSPSGSIARLVATHSDSQNASPGHTVANPPNTSNLEEWKALVIEWLGNYGLPLNSSEDEPWVEVEVWEPFYSRLAGEVWRQNEEGASVLPLKRILWPARYCFTRKKPTSLDPFLGINDTFPVIDEPLGFAEKWLGMGQLNHETDSKPASRPEAETKDQETPLSRPDLPEGIESLSRAAEYPDLQASNLVYPTPPDGAFPVGPNPPPASDAAAEDLDSRHLTNRALVNVKSKEETSARDRSDHDVLMSFGPSPGLIVGSGLYDTNDDDDDDLFGEINQRDFGSKGITDADFSFFDDPEFNHLGGDVSEMDVGAQETPEIAVDAEEPKAHPLSLEQPLTNDNLPGRRDTTEQVDTVLAHPEEKISNLQPADVPLSANMQISSPVNEDNQTISPPLSPIEVKKTLFAGPNEDSKLSVQKGHLQGHYNPVAFKANILDWDQKYGAEGKFRVSGAVVNHHTVPASTTGDIPTIGLPRRNARTKNPYVPARNNDKPKSPASDVDQPLPSDSDFDSTSDTSDDSDGNLSNSDESVATFVTRKRKRARSYSGSSVNLPQQKPLARSEQSIATSRTDDLVFLGNFLSTFSDWSMTGYFSAIQKQLAPVLIRKDAQIEVAQLLVEQVTQSCLDHKVDGILNVSEFESKTYSLRTFLEDTAFMGEIERLDLNGFVSLQENSGLSPPLTATMSRQSSQRKENGKSSILKLAPPHLRIRRGKDYLEVLPPAISFWETFGLEPAYGSKDIYAYCIHPQTAAEAANDFLERLGLLYSSCNLGQHTRASRSTGFDRGMCSWNIGAPGEFNYHYIMQSLKSICDKLVTALLKSPPTRDSVVVYIINPFSHAAALADICSAFYDLFQKYIDEVENQQAGQASELVLQIVPFHFIMSTESLVVPPQAQYLSLALEVYSRCPPKSLQSCLLNCAPPMLIAEPVPKTINFKLAPDSSSPLQEAKSLHIACSRSYDQRWVSVSWTDNTGTFQRTLSYCLRFQNSNATRNILEVRTEIWAATKMIMEKTQARWKIIIANTEPVDQDEVDTWTSLVEQYNTTKPFPSDLTILYVNTTPDLYLEPPPQPLSMSVFNPQISSTPVATPNPSGNAFSPEQPGNAPTPPSGGNAPTPTEIPPDAESECLLTDICDESWGIILSHCLNSSPHLTDYRPALASGYLLRRKGPTDADGAFAMNVNLIYSQKPASLYENLLREIIARYRDLATLARARGTRTVQQNTFPWHIATALRAQELLSYVL
Length1429
PositionKinase
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.380
Instability index53.49
Isoelectric point5.06
Molecular weight157007.19
Publications
PubMed=16372009

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32067
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     756.63|     259|     280|     386|     665|       1
---------------------------------------------------------------------------
  310-  478 (164.81/110.42)	GINDT.FPVIDE..PlGFAEkwLGmGQLNhETD....SKP......ASRPEAETKDQETPLSRPDLP.................................................................................................................................................egieslsraaeypdlqasnlvyPTPpdgAFPVGPNPPPASDAAaeDLDsRHLTNRAlvNVKSKEETSarDRSDHDvLMSFGPSPGLIVG.......SglYDTNDDD..DDDLFGEINQRDFGSK
  479-  761 (408.81/228.37)	GITDADFSFFDD..P.EFNH..LG.GDVS.EMDVGAQETPE.IAVDAEEPKAHPLSLEQPLTNDNLPgrrDttEQVDTVL..AHPEEKISNLQP..ADVPLSAN...MQISSPVN.EDNQTISPPLSPIEVKKTlfAGPNEDSKLSVQK...GHL...QGHYNPVAFKANILDWdQKYGAEGKFRVSG..AVVNHHTVPASTTGD.IPTIGL...............prrnartKNP...YVPARNNDKPKSPAS..DVD.QPLPSDS..DFDSTSDTS..DDSDGN.LSNSDESVATFVTrkrkrarS..YSGSSVNlpQQKPLARSEQSIATSR
  762-  954 (183.02/87.10)	..TD.DLVFLGNflS.TFSDwsMT.GYFS.A..IQKQLAPVlIRKDAQIEVAQ.LLVEQ.VTQSCL....D..HKVDGILnvSEFESKTYSLRTflEDTAFMGEierLDLNGFVSlQENSGLSPPLTATMSRQS..SQRKENGKSSILKlapPHLrirRGKDYLEVLPPAISFW.ETFGLEPAYGSKDiyAYCIHPQTAAEAANDfLERLGL............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.52|      17|      17|    1276|    1292|       2
---------------------------------------------------------------------------
 1276- 1292 (34.93/15.71)	TPNPSGNAFSP.EQPGNA
 1294- 1311 (28.59/11.53)	TPPSGGNAPTPtEIPPDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.01|      10|      20|     224|     233|       4
---------------------------------------------------------------------------
  224-  233 (21.09/12.33)	PPNTSNLEEW
  247-  256 (20.93/12.18)	PLNSSEDEPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.59|      14|      19|    1205|    1218|       6
---------------------------------------------------------------------------
 1205- 1218 (25.41/13.84)	WKIII...ANTEPVDQD
 1223- 1239 (21.18/10.31)	WTSLVeqyNTTKPFPSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32067 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQASNLVYPTPPDGAFPVGPNPPPASDAAAEDLDSRHLTNRALVNVKSKEETSARDRSDHDVLMSFG
2) KFRVSGAVVNHHTVPASTTGDIPTIGLPRRNARTKNPYVPARNNDKPKSPASDVDQPLPSDSDFDSTSDTSDDSDGNLSNSDESVAT
3) MSVFNPQISSTPVATPNPSGNAFSPEQPGNAPTPPSGGNAPTPTEIPPDAES
4) PEFNHLGGDVSEMDVGAQETPEIAVDAEEPKAHPLSLEQPLTNDNLPGRRDTTEQVDTVLAHPEEKISNLQPADVPLSANMQISSPVNEDNQTISPPLSPIEVKKTLFAGPNEDSKLSVQKGHLQG
5) QLNHETDSKPASRPEAETKDQETPLSRPDLPEGIESLSRAA
377
639
1262
491
333
444
725
1313
616
373










Molecular Recognition Features






MoRF SequenceStartStop




1) GEINQRDFG
468
476