<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32061

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPSMQQPQPPPSQALPQQLSQLHHPQHHQPPPQAQQSPIAQNQPPQIPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQPQAAVQAAQSAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTTQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWIDRQWQYGRCQPLSAVSAPVHDLKAAAAP
Length766
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.03
Grand average of hydropathy-0.689
Instability index86.91
Isoelectric point9.43
Molecular weight83791.13
Publications
PubMed=10349636
PubMed=11042159
PubMed=11076861
PubMed=11217851
PubMed=12466851
PubMed=16141073
PubMed=19468303
PubMed=21183079
PubMed=24129315

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32061
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.17|      31|      33|     161|     192|       1
---------------------------------------------------------------------------
  174-  206 (54.34/ 7.67)	QQQAALQQQQQQQQQQQQQQQFQ.....AQQnaMQQQF
  289-  324 (44.83/ 6.08)	QLHHPQHHQPPPQAQQSPIAQNQppqipPQS..QSQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.66|      19|      19|     224|     242|       3
---------------------------------------------------------------------------
  230-  249 (32.23/ 6.72)	QSQQQQIQQQQLQrMAQLQL
  250-  269 (34.43/ 7.76)	QQQQQQQQQQALQaQPPMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.22|      22|      22|      95|     116|       5
---------------------------------------------------------------------------
   82-  103 (39.82/12.80)	MNALQSLTGGPTPGAAGI.....GMPP
  104-  130 (39.40/12.60)	RGPGQSLGGMGGLGAMGQplplsGQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.91|      23|      23|     560|     582|       6
---------------------------------------------------------------------------
  538-  561 (30.98/21.12)	KQLSKyIEPLRRMINKIDKNEDRK
  562-  584 (37.93/27.81)	KDLSK.MKSLLDILTDPSKRCPLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.02|      20|      22|     352|     372|      10
---------------------------------------------------------------------------
  352-  372 (32.85/13.04)	VQQPQVQPQVqQVQPQVQPQA
  390-  409 (30.16/ 7.86)	IAEALAQGGM.HVRARFPPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.26|      40|     127|     599|     645|      11
---------------------------------------------------------------------------
  599-  645 (63.69/39.32)	DMAVPT..PPPPPVLPTKQQDL..CQPlLDAVLAnirsPVfnHSLYRTFVP
  723-  766 (65.58/25.84)	ELSVPAdyPAQSPMWIDRQWQYgrCQP.LSAVSA....PV..HDLKAAAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.21|      14|      22|     683|     696|      16
---------------------------------------------------------------------------
  683-  696 (24.63/14.70)	VARLDPKFLVNLDP
  708-  721 (26.58/16.48)	ICKLDDKDLPSVPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32061 with Med15 domain of Kingdom Metazoa
Unable to open file!