<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32053

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGCFLGYSEAPANGFTILKHLSRLKDLELRLRNSDCLVSSYPRRLGLWVFSATPEFESVRSLRSDESKGEQSRLAVGSSTLKVSASGSVTPRELVKNLSTDPQTAGGSTGSQRPQGTPTPTRRVDSYSSSVAIYAAFISAITGSLNLQLIRRSSAIPLGSRTLFTIIERDYYETSGIVNDDPSSISALTTLQVQLTSVGKLTVSLQTTSQPGIAPLCRLGESPSDICDVAPGADIWLSPSGSVARLVSTKPGPPNTSSPFPPTGSIGIDSLGAAGRKQWKANVLEWLRNFGLPMDSVHETAWVEVEVWEPFYSRLAGETLRLNEDNSSTLPLKRVLWPAVYCFRRTKSASPGSSQWIENACPVVGDPLDFAENWRVVEKPKQDETSPKPPSSHPEQQSRNPEPSAATTDILEGIESLSRASEYPDLQTVSLVYPTPPDGAAAMGLNLAGPSDTFAEEPDLVPSLLQNQSKPKYYEQLTTKDRSEADPSAGFGPLGGLAVGSGLYDTNEDDDLFGDMDERDFGTKGITDADFNFFDDPSFAAMDTDVPADDAQEVPGMVDLEVTEAHPTISEGALLEDFAAQKTPAEILEVAQASPDEVTPKVQPEHMDAEETTVAASPHIEQNQTISPPLSPVEIKRILLPEPEGDNHVPTKGSRKQSYYNPVAFKPNMSAWDQKYGADGKFRFTTAGPSASKVYTNSDIPTVGMPRRNKKYPTAGAGLMSLDGHASPSSEGQHLQTVSDSSSDTSDDSDGSASESDAPPLPSRKRKRARSNSVGSPAISQVKSLGEAEQEIPVHRPEHSIFLGNLLSTFSDWSMTGYFSLTENRLFPVLTRKDMQIQIAQLFVDQITQSSLDHKLDGGFCLSDLDNKAYSVQTFFEEEGILGTIERLDLNSWISLQENEQASPAPNGAVSRQSSQRKEMGKGSITKLSPPHLRVRRGKEYLEALPPAISFWETFGLEPADGPKDISAYCIHPQIAADAADVFLERLGLLYASCNLGKHVRGCRSSAFERGLCPWDVGSLETAHFLPAMQSLKLICEDLGTALLKSSPSNDSLVIYIINPFAHASALVDICSAFWCLFQKYIADTGKQQARQLNEVVLQIIPISFIMSTDSMVVPPQAQYLSLALEIYSRCPPKALQSSLVNCAPPVLLAEPLPRTISFRLASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLRYRNASAVRSISDVRSEIWVATKDILDRIQARWKVFVVSTGPVDQDEVDAWTSFIEQYNKANSIPLELTILSVNTAPDLHLEPPFLPMSMSIFNPQTSSTPVATPNASGNVFSPDQSGSAPTPPSGGNAPTNAPTPTEPTLEAETESVLTDICDESWGVILSHRLNNSPHLTEYRPALASGYLLRRKGDTDGDGVYAMTLNLIYTQRPSSCEAILRETLGMYRDLGTLARARGTRTVQRNTLPWHIATAVRAQEMLSHVL
Length1467
PositionKinase
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.346
Instability index55.80
Isoelectric point5.04
Molecular weight159639.15
Publications
PubMed=16372010

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32053
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.79|      33|      34|     644|     676|       1
---------------------------------------------------------------------------
  644-  676 (61.99/41.64)	EGDNHVPTKG.SRKQSYYNPVAFKPNMSAWDQKY
  679-  712 (53.80/35.06)	DGKFRFTTAGpSASKVYTNSDIPTVGMPRRNKKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     144.39|      31|      34|     401|     431|       2
---------------------------------------------------------------------------
  401-  429 (45.15/21.16)	.....................PEP..SAATTDI.LEGI...ESLSRASEYPDLQTV
  430-  463 (36.89/15.93)	SL.................vyPTPpdGAAAMGLnLAG....PSDTFAEE.PDLVPS
  464-  512 (21.62/ 6.26)	LLqnqskpkyyeqlttkdrseADP..SAGFGP..LGGLavgSGLYDTNEDDDL...
  713-  738 (40.73/18.36)	.....................PTA..GAGLMS..LDGH...ASPS..SEGQHLQTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.00|      13|      22|    1296|    1308|       3
---------------------------------------------------------------------------
 1296- 1308 (25.35/12.83)	SMSIFNP.QTSSTP
 1315- 1328 (20.65/ 9.02)	SGNVFSPdQSGSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.06|      14|      15|     917|     931|       4
---------------------------------------------------------------------------
  917-  931 (21.47/14.84)	RKEMGKGSITKLsPP
  934-  947 (25.58/13.31)	RVRRGKEYLEAL.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.09|      16|      29|     551|     567|       5
---------------------------------------------------------------------------
  551-  567 (25.24/22.99)	AQEVPGMVdLEVTEAHP
  580-  595 (27.85/19.24)	AQKTPAEI.LEVAQASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.41|      23|      28|      77|      99|       6
---------------------------------------------------------------------------
   77-   99 (37.47/20.42)	GSSTLKVSASGSVTPRELVKNLS
  106-  128 (41.94/23.85)	GGSTGSQRPQGTPTPTRRVDSYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.72|      15|      16|    1225|    1240|       7
---------------------------------------------------------------------------
 1225- 1240 (23.73/17.06)	IW.VATKDI.LDRIQArW
 1242- 1258 (18.99/ 8.34)	VFvVSTGPVdQDEVDA.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      17|      23|    1012|    1032|       8
---------------------------------------------------------------------------
 1012- 1032 (21.84/27.73)	LCPwDVGS..LETAhflPAMQSL
 1035- 1053 (25.86/14.08)	ICE.DLGTalLKSS...PSNDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.42|      28|      28|     214|     241|      10
---------------------------------------------------------------------------
  180-  199 (22.88/ 6.53)	.......DDPSSI.SALTT.LQVQLTSVG
  214-  241 (49.47/22.69)	APLCRLGESPSDI.CDVAPGADIWLSPSG
  244-  272 (43.07/18.80)	ARLVSTKPGPPNTsSPFPPTGSIGIDSLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.42|      26|      29|    1163|    1188|      13
---------------------------------------------------------------------------
 1156- 1186 (38.09/28.25)	TIsfrlaSEKTSPLQEGKCLHIAYSKSQDQR
 1187- 1216 (38.32/28.48)	WI.gvawSDNSGALQRTISYNLRYRNASAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.09|      17|      33|     784|     801|      14
---------------------------------------------------------------------------
  784-  801 (26.71/16.25)	SLGEaEQEIPV.HRPEHSI
  820-  837 (24.38/10.56)	SLTE.NRLFPVlTRKDMQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32053 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PAEILEVAQASPDEVTPKVQPEHMDAEETTVAASPHIEQNQTISPPLSPVEIKRILLPEPEGDNHVPTKGSRKQSYYNPVA
2) PDGAAAMGLNLAGPSDTFAEEPDLVPSLLQNQSKPKYYEQLTTKDRSEADPSAGFG
3) PSFAAMDTDVPADDAQEVPGMVDLEVTEAHPTISEGALLEDF
4) QTSSTPVATPNASGNVFSPDQSGSAPTPPSGGNAPTNAPTPTEPTLEAETES
5) RELVKNLSTDPQTAGGSTGSQRPQGTPTPTRRV
6) WRVVEKPKQDETSPKPPSSHPEQQSRNPEPSAATTDILEGIESLSR
7) YGADGKFRFTTAGPSASKVYTNSDIPTVGMPRRNKKYPTAGAGLMSLDGHASPSSEGQHLQTVSDSSSDTSDDSDGSASESDAPPLPSRKRKRARSNSVGSPAISQVKSLGEAEQE
584
437
537
1303
92
374
676
664
492
578
1354
124
419
791










Molecular Recognition Features






MoRF SequenceStartStop




1) EIKRILLPE
2) RKQSYY
634
655
642
660