<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32044

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSHKPDNTDPNALTFEITTSTKVHPPLSLAAAKELWIFWYGEEPDLSDLVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASSSGQSGLGSGSGAGSSSGAGPGQSQTPDSNGTSGTEPNEGAEAKAVPPAHARKVMLAPFGIAAILTGNSYRANDPVAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHLEFAELQRASAGVGSGAEAAALSSASCPPAASASASAATPPGASQAKDGGASRKAVPQAVSALERLSFQPYYDQRPTSGFSFNTHNTHIPAAAAVEMPERAWQDCVMNTLHVEAAAAAAAAAAAAAASAAAASGSAASATSGVPDEDEQNKPPADSKQLVQQQIQQQQQQQQQQQRQKLWNFVDPMQKAPCICTKHLCSTPHGTPHGGASTYSRNSLGGDSSLPVASVGSPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPSYTDHAAGGGASQSLTGPGSVPPQQQQQQPPTPTAGGTLTTSGANASAAGAASGTAGTPGGAASTTTTTTAQCGTISVKKLEMQQQTPAAHQIPIKPEPGTVRGTTVTSTTDAINNLLSLYKPPKLKLKDPDSFYDDEWLKEVIYDFQFQENWDYLTVKRPKMEEASKQKRTRYAKNLYEGHTHVKPLMPSPGAVYGSQLLSLDVQAAASGGAGGGGAAGSSSSGGLVGIVNSTANGSDAEAEGSSFFHGLDIKTEPGLHSPSCKETKSSSGGTTGASSGGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIDELKRSTAVASAVVAAAAAAAAVASSGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTSSIMAVAPPIQVPAAVIAAAAAAASASASVTTVSAVVALGTQSSLKLLKQEYNVELGSPLEEPIDDWNYVYRPPQQEKFVGSSRYAPLTNLPSQTLPSISMPTNCYYKPTWSTHKSRAATMAKVAAAQQQKHQKHQALQQCIQLHQQKLQQLQHQHQQQQQAAAASHAHQRHQQLHELLSAAPRTPQTAMPSPSTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPISPGPGGVGVPFPRNSPMLRQTPTHPPPPYPYDLGVASPATSTSSYLNRQLHSQEAQPHPHTPQSMHHIQSGMHGLGSGAGGAGHHHLGNMMPYTGDAGIASGPASAVAVPSGLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPAHSANAAATAGQRLLNGPSSSSSSAASFGGGLRMISAFGGSPASSSMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGKADDPGRNKQPSLLSLIQSLCRKNQAKAASGPGGDTSSSSALEKVTGAAASAGQLEHLAHAIFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRLFGTGGAPAASMASIANVLEFMDAHDVISLALEQARMAFEHQRMDNMLEFHGNSSQQLTAFHAHPPALRQKLSILGSGCLTVHKWPYLPVGFTRSNKEIVRTMNSIQPMLQNAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVAGCTRSYFRELSSTYEMCKLGRHTPIRGWEGILQVAASRNVPPEREQTPLDDWLRTLDHPLAEQIRRYAVAFLHQLAPYLSRVPGDKTLLNPPDGSASGGSSSKGGHHSGGSGTDPLHNDPIKQEPGTETPLSAAPTLDSSSSSSNNNNQQDSKDGVKGSAGGDTKPALILGDPLGVGETLEDINPAAIVLYVVNPFTFASDSCELERLALIALLRCYAELLKAVPDSVRAQMNIQIISLEAVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMYERTDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKVCINIDVPNRARRRKAPARYVALKKLMDFVMGIISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGELFWGDTHMDRVSNHGSPGRMEDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEEVCPVFLKTALHLHVPNIQIADDILNSTNAHQSANDHPLDSSLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2641
PositionMiddle
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.373
Instability index50.57
Isoelectric point6.16
Molecular weight281987.17
Publications
PubMed=15632085
PubMed=17994087
PubMed=23185243

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32044
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1210.06|     420|     703|     198|     732|       1
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  245-  732 (658.98/303.04)	SGSGAGSSS............GAGPGQSQTPDSNGTS....GTEPNEGAEAKA.VPPAHA...RKVMLAPFGIAAILTGNSYRANDPVAEKI...LEDWASFFPLCNKDNT.....DVPPVV...EV.VS.GGHKMYHPTNYVLVTDLDDMEHLefAELQRASAGVGSGAEAAALSSASCPPAASASASAATPPGASQAKDggaSRKAVPQAvsalerlsfqPYYDQRptsgfsfntHnthiPAAAavemPERAwqDCVMNTLHVEAAAAAAAA......AAAAAASAAAASGSAASAT.SGVPDEDEQN............................KPPADSKQLVQQQIQQQQQQQQQQQR...........QK.........LWNFVDPMQKAPCICTKHLCSTPHGTPHGGaSTYSRNSLGGDSSLPVASVG........SPATPAPS....PHP.NSAhsqptsvppaeqLLNMSP.HAPtsvsnlqqPPTPIDhlLDKNTPApTPTDQHDNK...SITASPYVHQTPSVEPPSYTDHAAGGGASqsltGPGSvpPQQQQQQPPTPTAGgtlTTSGAnASAAGAASG
  893- 1188 (272.65/80.08)	GGGAAGSSS............SGGLVGIVNSTANGSDaeaeGSSFFHGLDIKT.EPGLHSpscKETKSSSGGTTGASSGGG..GNLFTAEGLnpsLNDLEQLFETSSNDECssvqiHTPPDS...NN.PSnGGCSAV..TN.....TIDELKR..................STAVASAVVAAAAAAAAVASSGAGNIQAED...LTKMFPTP..........PSHEQQ.........H....PNSS....PCQT..DVVMTDLSVDTSSIMAVAppiqvpAAVIAAAAAAASASASVTTvSAVVALGTQSslkllkqeynvelgspleepiddwnyvyRPPQQEK................................fvgssryapLTNL..PSQTLPSISMPTNC...........................................................................................................................................................................................
 1226- 1430 (195.79/65.49)	.........................................................................................................................................................................................................................................................................................................................................................QLHQQKLQQLQHQHQQQQQaaaashahqrhQQ.........LHELLSAAPRTPQTAMPSPSTVPQPLSSGG.SQLLLNQLNCPQAPPGSSMQqlmqragmSPISPGPGgvgvPFPrNSP............MLRQTPtHPP........PPYPYD..LGVASPA.TSTSSYLNRqlhSQEAQPHPHTPQSMHHIQSGMHGLGSGAG....GAGH..HHLGNMMPYTGDAG...IASGP.ASAVAVPSG
 1516- 1665 (82.64/ 6.40)	PSSSSSSAAsfggglrmisafGGSPASSSMPGAGSGH....GHGPNGGSNSSScTPPS..............SNPHITG..YVDDDPV........ECTCGFSAVVNRRLS.....HRAGLFyedEVeIT.G..KADDPGRNKQPSLLSLIQSL..CRKNQAKAASGPGGDTS..SSSALEKVTGAAASA...................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.05|      15|    1262|     765|     790|       2
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  765-  779 (30.91/17.95)	TPAAHQIPIKPEPGT
 2030- 2044 (31.15/ 8.68)	TDPLHNDPIKQEPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.18|      14|    2049|     147|     166|       3
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  132-  145 (27.11/24.40)	ALWNGTWKGALTYE
  153-  166 (24.07/ 9.03)	ALHNLMERFVLTKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.48|      25|    1125|     866|     890|       7
---------------------------------------------------------------------------
  866-  890 (43.78/23.80)	LMPSPGAVYGSQLLSLDVQAAASGG
 1992- 2016 (45.70/25.22)	LAPYLSRVPGDKTLLNPPDGSASGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.39|      11|      36|    1208|    1218|       8
---------------------------------------------------------------------------
 1208- 1218 (20.78/12.35)	AAAQQQKHQKH
 1245- 1255 (20.61/12.18)	AAAASHAHQRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.22|      16|     626|     822|     848|      10
---------------------------------------------------------------------------
  831-  847 (25.78/40.52)	WDYLTVKRpKMEEASKQ
 2348- 2363 (29.44/ 7.60)	WSYLLSKQ.QLQKASKQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32044 with Med13 domain of Kingdom Metazoa
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