<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32041

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGTNAKCSLGAGGGFGSHIPSIEEKNRQIQQETMMEKLRAKYRNKPKTYEEIKKSVRMYFIEKHYALDPLCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDASGNLSDVKVHHECKIEQQSSELVKCLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIYSLYSHQMQNRTGDSYDIMNSSAVGLVLQRRGGHPMKLTYFCPPIHLAEGESKLASSEFSIDQVMHSSHGLSATVNLEGSSANKLQIMPILSFSRDPQTGLELPTYAQLNQNNSMLMPATYVLRLNKPMPVCYETLKSLGLPGVEGMAAAPSPPVATVLNLIVQTASKQAIKNTQRGLYVNLPKETHCYFFTDNRKLQGTLISSLPFTEPAQVPKIMTFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQATCSIYCLNNEYEVLSQKLTRTVRKVLSIPMVIYKLLKCWDEEHQFKLHGVIGSGAGAGAGSGAGAGTGNGGGVGTGLAHAHNFNQFAMEAGPSLDGSLPSGGFTSINSLKMEAKSRSLADAFVASTSAAAAIASLINLKRETDPQSALGPVSSGNSSSSGSSSTVLAAAKATDHEIADKYKNIWKDKTPNLKHCVSITPIPGDGKTGGGGAGGGPVGSSVGGVVPTVDVQRTGGIEIIPLNAQSQTSGTRDGGSATTTTAPTTITITPITGKDPAKESSKKSSSSAPAGVSIATKRPHESSTSASSSSAGSGGSSSSTSSTGSSSSCSTDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAAGGDASATGGVVRKFSSPSSSPKAGGSGQGILSGVPPARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAGTSLSPKGDKSTSSVGPPPSASVGSSTGASANPSLVRSFASVGAPPPPPPVPPLSSAISSSSSSSSSCSSSGSAGGSSSQQSGSSGIKKEKSSAAGPSSSSGASSGPSGGSGGVGGVSPASVVSVASVAAAVAALKTSQQQQQQQQLKSSVASLSHLAAGGSLGSYAAAGGAAAVAAAAATVGAGAGAVTGASALELSALRKGLAGGAVSPYSL
Length1146
PositionMiddle
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.274
Instability index53.45
Isoelectric point9.23
Molecular weight118054.34
Publications
PubMed=15632085
PubMed=17994087
PubMed=23185243

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblMetazoa
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32041
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     377.21|      57|      57|    1012|    1068|       2
---------------------------------------------------------------------------
  571-  620 (32.08/ 6.26)	............A............ME.AG.......PSL.D...GSLPSGGFTSINSLkmeaksrS..LAdAFVASTSAAAAIASLI
  628-  662 (35.77/ 7.95)	PQ.......................SA.LG.......PVS.SGNSSS..SGSSSTVLAA.......A..KA.TDHEIAD.........
  665-  723 (49.36/14.17)	.....KNIWKDKTpnlkhcvsitpiPG.DG.......KTG.GGGAGGGPVGSS..VGGV.......V..P...TVDVQR.TGGIEIIP
  756-  804 (34.19/ 7.23)	KDPAKESSKKSSS............SApAGvsiatkrPHE.SSTSASSSSAGSGG.SSS.......S..TS.S...............
  898-  937 (43.20/11.35)	...........NT............AS.NS.......PKS.PFGTHS.PKHGSSGK.............P..SMSTLKSAATAGTSLS
  938-  982 (54.53/16.54)	PK...........................G.......DKS.TSSVGPPPSASVGSSTGA.......SanPS.LVRSFASVGAPPPPPP
 1016- 1068 (87.35/31.57)	....SSGIKKEKS............SA.AG.......PSS.SSGASSGPSGGSGGVGGV.......S..PA.SVVSVASVAAAVAALK
 1072- 1116 (40.72/10.22)	QQQQQQQL...KS............SV.AS.......LSHlAAGGSLGSYAAAGGAA..................AVAAAAATVGA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.46|      38|     104|     144|     183|       3
---------------------------------------------------------------------------
   69-  108 (58.98/38.88)	DP.................................LCKATLQSAldKLQHYIKVTSRHGLVERLESLSR..QLGL
  109-  181 (41.48/32.41)	KFmedqqllfistdmfyveilldasgnlsdvkvhhECKIEQQSS..ELVKCLKSGDFADFTVQLEGLSSiyQLNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.27|      10|     568|     540|     549|       5
---------------------------------------------------------------------------
  540-  549 (19.93/ 8.13)	GAGAGSGAGA
 1117- 1126 (18.35/ 6.90)	GAGAVTGASA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32041 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KHCVSITPIPGDGKTGGGGAGGGPVGSSVGGVVPTVDVQRTGGIEIIPLNAQSQTSGTRDGGSATTTTAPTTITITPITGKDPAKESSKKSSSSAPAGVSIATKRPHESSTSASSSSAGSGGSSSSTSSTGSSSSCSTDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAAGGDASATGGVVRKFSSPSSSPKAGGSGQGILSGVPPARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAGTSLSPKGDKSTSSVGPPPSASVGSSTGASANPSLVRSFASVGAPPPPPPVPPLSSAISSSSSSSSSCSSSGSAGGSSSQQSGSSGIKKEKSSAAGPSSSSGASSGPSGGSGGVGG
676
1048










Molecular Recognition Features






MoRF SequenceStartStop




1) GIKKEKSSAA
1018
1027