<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32040

Description "Uncharacterized protein, isoform A"
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHSSNVNASRVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCIVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQTHDKASSNGSHSAGLTTASSGNSNGISVNSSGGNAAPPSATANVIPVPSMSSPLPPIHSPANGQPSTAGGVVGSGSVIPPAGALGGGVSSGPGGPGGCSANSSTAVGAPVPPGSSISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVSKKLAQLLNAAVEQQGIKDVDGGVGAGAGGGENKLQHDPFELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLVGSPLDHLPLAPSVLPMPTRCPRTNTEIRRQLRAAESEIVLRTQHAEQRWFASKWLSAGKNHYTKVLATLDHLDTHCFDRMEQCNSIDTLYVHIFPRRRDEDQQDPQQQQQPRPVYEPKQDKDTVRILCEWAVSSQRWGEHRAMVVANLLDKRQIDVTSTPSEQSSDKEDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDDHLSSAQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLSLESVLASKASTTATKSSPAAAATQATTTHGFDDDPFGGGIDFKHNEFDDSNVDDDLDKLVQNIKEKGQHDAPDSPKIGPPGDGEPSTGGAGGSISRHYVYTKHFPIPQDESSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTAKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDNLLKELPEVEHQLQLKKSNMVRGYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHVNNPSECSSAERCILAYLSDLHESCVLLQGKEQSTEYYQQLQCIKRFKDIFNTPEQLSLPPQGYNPQLLQELFVAPRRGGKLEPHWLRQLHESSANVYSFVSNAVIAVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGGQVDIGQGKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGGEMSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGSDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTSMAGGTGSSSSGGVGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGNSLTSEQEALQQPSVGGLEQISLLEFAQAVLKQICAQEHVLERCLKNAEGLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRAMIVRILENLGQWTLRISWLDLQLMYRQSMGNNAELNVWLDTVARAAIDVFHMEEIILPGSLKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGIGGVAARNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYSQLSQCLQSFAELDTIGGTDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDSQSERDENKKLYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDTKGNKICDMEKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMMKADTPSSVDQSPSAVVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQPPNVQQQQQQMQQQQQHMQQQQMQPNQMGMQMNMPMNMQQFAPNPNMMQQSALMQQQQQMQQMGTNQLQQQLNVGGGNGQQNPQMNFMQQGPGGGAAGPQGLPGQQQQQQWHNAPQQQQPPQQYHNHYAPHQQNMQSNRIERPPQNANSKQALSQMLRQRQPFQQQQQQQPGGGFNPMQQQQPQAQQQPGPQQQQMNPNQMRQQQMTAQQNPQSVAAFNAMQQQQQQNAQQQQQQMNPNQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGIPQNSMMQQQMTQGMVGMVNPNANQMMQTGGAQGGNGVGVGVGVGVGVGVTTGANPNMGMGGMPQQGMMQQQAQQQPQQQVQFQNFQNQYQQQQQQQQQQGMQQQGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAAQQQQQQQQQRGVPGGMMAGNRGQYINQAPNVTMSNMMGPGPGGVGVGVGVGVGQVPPYARQQPAGGGKPGVLSTQQQFQQQQQQQQLRHQQMMQMQGMGGGGGGGMGAGPQQASGAGVGGGGGGMVQQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQHQPPPY
Length2561
PositionKinase
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.541
Instability index54.58
Isoelectric point7.94
Molecular weight281919.08
Publications
PubMed=15632085
PubMed=17994087
PubMed=23185243

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32040
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     204.17|      16|      18|    2495|    2510|       1
---------------------------------------------------------------------------
 1975- 1989 (24.28/ 6.47)	QQ...P.PNVQQQQQ......QMQQ
 1990- 2008 (25.10/ 7.03)	QQqhmQ.QQQMQPNQM.....GMQM
 2045- 2059 (24.14/ 6.38)	QQ...Q.LNVGGGNG......QQNP
 2060- 2075 (24.06/ 6.33)	QM...NfMQQGPGGG......AAGP
 2202- 2216 (28.17/ 9.09)	QQ...N.AQQQQQQ.M.....NPNQ
 2302- 2322 (25.15/ 7.06)	NM...G.MGGMPQQGMmqqqaQQQP
 2349- 2364 (23.82/ 6.17)	QQ...G.GGVGVGVGV.....GMAP
 2494- 2508 (29.45/ 9.95)	Q....G.MGGGGGGGM.....GAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     633.46|      73|      75|    2081|    2153|       2
---------------------------------------------------------------------------
 1860- 1941 (54.23/12.98)	.............................................WFGAV...............KLER..KPLtyeeahrnlKYHTHslvkpssyyYEPL...................................PLP...........................PED...IEPVPEKICIKD......E.MM................KADTPSSVDQ.SPSAvvGT..GRGR
 1948- 2043 (74.94/20.63)	R.......................................KRKPKNPKTP...........pvvnTQQQ..QPQ.......................LAPQPqqppnvqqqqqqmqqqqQhmqqqqmqpnqmgmqmNMP...........................MNM...QQFAP.NPN...........MM................QQSALMQQQQ.QMQQ..MG..T.NQ
 2081- 2153 (146.11/46.89)	Q.......................................QQQQQWHNAP...............QQQQ..PPQ.........QYHNH.........YAPHQ.................Q................NMQ...........................SNR...IERPPQNANSKQA...LSQ.ML................RQRQPFQQQQ.QQQP..GG..GFNP
 2154- 2196 (74.62/20.50)	........................................MQQQQ....P...............QAQQ..QP.........................GPQQ.................Q................QMN.....................................PN.....Q.........M................RQQQ.MTAQQ.NPQS..VA..AFNA
 2197- 2282 (86.11/24.75)	M.......................................QQQQ......qqnaqqqqqqmnpnqQQQQfmRGG.........NMRPG.........MAPNQ.................M................NQM...........................NMG...GQGIPQNSMMQQQ...MTQgMV................GMVNP.NANQ.MMQT..GGaqGGNG
 2283- 2380 (43.27/ 8.93)	VgvgvgvgvgvgvttganpnmgmggmpqqgmmqqqaqqqpQQQVQFQN....................................FQNQ.........YQQQQ.................Q................QQQ...........................QQG...M....Q................qqgggvgvgvgvgmapN..Q..QQQQ.QANM..MG..NFNP
 2386- 2467 (86.35/24.84)	N.......................................RNNPDFMAAA...............AAQQ..QQQ.........QQQQR.........GVPGG.................M.................MA...........................GNRgqyINQAP...NV..T...MSN.MM.gpgpggvgvgvgvgvGQVPPY...A.RQQP..AG..GGKP
 2470- 2558 (67.83/18.00)	L.......................................STQQQF...................QQQQ..QQQ.........QLR..............HQ.................Q................MMQmqgmgggggggmgagpqqasgagvgggGGG...MVQQQQSMNQQQTpnlVAQ.LQ................RQNMMGQQQQyQHQP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.11|      11|      15|     567|     577|       7
---------------------------------------------------------------------------
  567-  577 (22.72/17.30)	LDHLDTHCFDR
  584-  594 (21.39/15.79)	IDTLYVHIFPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.92|      13|      15|    1109|    1121|       8
---------------------------------------------------------------------------
 1109- 1121 (25.35/14.10)	PPQG..YNPQLLQEL
 1125- 1139 (21.57/10.61)	PRRGgkLEPHWLRQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32040 with Med12 domain of Kingdom Metazoa
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