<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32039

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMSNYGNIMTDSPRSSPHGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLTKFKEKKFKESLSSFLQNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTAVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSTGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGAGLGNAAGGGIMGATGLGSLGGGPGPGAGTGMSNLSASMGPGVVGMNNFSSSMQMQQQQMPMQQQQMTSGGLLGSVLGVGGGPGGGGGGAGSGGGGGSLLMSQF
Length338
PositionHead
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.695
Instability index56.16
Isoelectric point9.95
Molecular weight35527.14
Publications
PubMed=15632085
PubMed=17994087
PubMed=23185243

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:EnsemblMetazoa
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32039
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.93|      30|      32|     224|     253|       1
---------------------------------------------------------------------------
  224-  253 (55.87/20.14)	PEPGVGLLPGGAGLGNAAGGGIMGATGLGS
  258-  285 (49.04/16.82)	PGPGAG..TGMSNLSASMGPGVVGMNNFSS
  313-  336 (40.03/12.43)	....VGGGPGGGGGGAGSGGG..GGSLLMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.26|      17|      32|     157|     173|       2
---------------------------------------------------------------------------
  157-  173 (32.27/17.44)	TPARKHKNKHKKHK.HKD
  187-  204 (25.04/12.29)	TGLETYEKKHKKQKrHED
  206-  221 (24.95/12.23)	KE.RKKRKKEKKRK.KKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.98|      30|      34|      40|      72|       3
---------------------------------------------------------------------------
   40-   72 (47.02/37.16)	LGKTPTIIHTGPFysmKEPPAK..AELTGDKDLMT
   76-  107 (43.97/26.16)	LHHTLTKFKEKKF...KESLSSflQNIPGINDLIT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32039 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSNYGNIMTDSPRSSPHGGRSPVVARQDSSGTLKTTISL
2) PLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSTGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGAGLGNAAGGGIMGATGLGSLGGGPGPGAGTGMSNLSASMGPGVVGMNNFSSSMQMQQQQMPMQQQQMTSGGLLGSVLGVGGGPGGGGGGAGSGGGGG
2
146
40
331










Molecular Recognition Features






MoRF SequenceStartStop




1) GSLLMSQF
331
338